Targeting IAP proteins for therapeutic intervention in cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-02

AUTHORS

Simone Fulda, Domagoj Vucic

ABSTRACT

Evasion of apoptosis is one of the crucial acquired capabilities used by cancer cells to fend off anticancer therapies. Inhibitor of apoptosis (IAP) proteins exert a range of biological activities that promote cancer cell survival and proliferation. X chromosome-linked IAP is a direct inhibitor of caspases - pro-apoptotic executioner proteases - whereas cellular IAP proteins block the assembly of pro-apoptotic protein signalling complexes and mediate the expression of anti-apoptotic molecules. Furthermore, mutations, amplifications and chromosomal translocations of IAP genes are associated with various malignancies. Among the therapeutic strategies that have been designed to target IAP proteins, the most widely used approach is based on mimicking the IAP-binding motif of second mitochondria-derived activator of caspase (SMAC), which functions as an endogenous IAP antagonist. Alternative strategies include transcriptional repression and the use of antisense oligonucleotides. This Review provides an update on IAP protein biology as well as current and future perspectives on targeting IAP proteins for therapeutic intervention in human malignancies. More... »

PAGES

109

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    http://scigraph.springernature.com/pub.10.1038/nrd3627

    DOI

    http://dx.doi.org/10.1038/nrd3627

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025792112

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22293567


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