The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics View Full Text


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Article Info

DATE

2011-09

AUTHORS

Eric Karran, Marc Mercken, Bart De Strooper

ABSTRACT

The amyloid cascade hypothesis, which posits that the deposition of the amyloid-β peptide in the brain is a central event in Alzheimer's disease pathology, has dominated research for the past twenty years. Several therapeutics that were purported to reduce amyloid-β production or aggregation have failed in Phase III clinical testing, and many others are in various stages of development. Therefore, it is timely to review the science underpinning the amyloid cascade hypothesis, consider what type of clinical trials will constitute a valid test of this hypothesis and explore whether amyloid-β-directed therapeutics will provide the medicines that are urgently needed by society for treating this devastating disease. More... »

PAGES

698

References to SciGraph publications

  • 1996-08. Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease in NATURE MEDICINE
  • 1998-06. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 in NATURE
  • 2009-10. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease in NATURE GENETICS
  • 1999-04. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity in NATURE
  • 2009-12. Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575 in MOLECULAR NEURODEGENERATION
  • 1991-02. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease in NATURE
  • 1998-01. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein in NATURE
  • 1999-12. Purification and cloning of amyloid precursor protein β-secretase from human brain in NATURE
  • 2002-04. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo in NATURE
  • 2006-03. A specific amyloid-β protein assembly in the brain impairs memory in NATURE
  • 2000-08. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease in NATURE MEDICINE
  • 2011-08. Potent amyloidogenicity and pathogenicity of Aβ43 in NATURE NEUROSCIENCE
  • 1995-08. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene in NATURE
  • 1998-08. APOE genotype predicts when — not whether — one is predisposed to develop Alzheimer disease in NATURE GENETICS
  • 1995-06. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease in NATURE
  • 2000-02. Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition in NATURE MEDICINE
  • 2009-10. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease in NATURE GENETICS
  • 2006-07. Human amyloid-β synthesis and clearance rates as measured in cerebrospinal fluid in vivo in NATURE MEDICINE
  • 2003-04. Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report in NATURE MEDICINE
  • 1999-12. Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity in NATURE
  • 2008-08. Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory in NATURE MEDICINE
  • 1991-09. Neuropathological stageing of Alzheimer-related changes in ACTA NEUROPATHOLOGICA
  • 2009-07. Transmission and spreading of tauopathy in transgenic mouse brain in NATURE CELL BIOLOGY
  • 1999-07. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse in NATURE
  • 2011-07. PSENEN and NCSTN Mutations in Familial Hidradenitis Suppurativa (Acne Inversa) in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2010-07. Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives in NATURE REVIEWS DRUG DISCOVERY
  • 1995-02. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein in NATURE
  • 2011-05. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease in NATURE GENETICS
  • 2009-07. Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease in NATURE CHEMISTRY
  • 2010-12. Distinct cerebrospinal fluid amyloid β peptide signatures in sporadic and PSEN1A431E-associated familial Alzheimer's disease in MOLECULAR NEURODEGENERATION
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    http://scigraph.springernature.com/pub.10.1038/nrd3505

    DOI

    http://dx.doi.org/10.1038/nrd3505

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21852788


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