Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-04

AUTHORS

Shankar Balasubramanian, Laurence H Hurley, Stephen Neidle

ABSTRACT

G-quadruplexes are four-stranded DNA structures that are over-represented in gene promoter regions and are viewed as emerging therapeutic targets in oncology, as transcriptional repression of oncogenes through stabilization of these structures could be a novel anticancer strategy. Many gene promoter G-quadruplexes have physicochemical properties and structural characteristics that might make them druggable, and their structural diversity suggests that a high degree of selectivity might be possible. Here, we describe the evidence for G-quadruplexes in gene promoters and discuss their potential as therapeutic targets, as well as progress in the development of strategies to harness this potential through intervention with small-molecule ligands. More... »

PAGES

261

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrd3428

    DOI

    http://dx.doi.org/10.1038/nrd3428

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049954039

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21455236


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