How to improve R&D productivity: the pharmaceutical industry's grand challenge View Full Text


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Article Info

DATE

2010-03

AUTHORS

Steven M. Paul, Daniel S. Mytelka, Christopher T. Dunwiddie, Charles C. Persinger, Bernard H. Munos, Stacy R. Lindborg, Aaron L. Schacht

ABSTRACT

The pharmaceutical industry is under growing pressure from a range of environmental issues, including major losses of revenue owing to patent expirations, increasingly cost-constrained healthcare systems and more demanding regulatory requirements. In our view, the key to tackling the challenges such issues pose to both the future viability of the pharmaceutical industry and advances in healthcare is to substantially increase the number and quality of innovative, cost-effective new medicines, without incurring unsustainable R&D costs. However, it is widely acknowledged that trends in industry R&D productivity have been moving in the opposite direction for a number of years. Here, we present a detailed analysis based on comprehensive, recent, industry-wide data to identify the relative contributions of each of the steps in the drug discovery and development process to overall R&D productivity. We then propose specific strategies that could have the most substantial impact in improving R&D productivity. More... »

PAGES

203

References to SciGraph publications

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  • 2007-02. The Prospects for “Personalized Medicine” in Drug Development and Drug Therapy in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2004-08. Can the pharmaceutical industry reduce attrition rates? in NATURE REVIEWS DRUG DISCOVERY
  • 2008-02. The State of Innovation in Drug Development in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2005-01. Macro trends in pharmaceutical innovation in NATURE REVIEWS DRUG DISCOVERY
  • 2004-05. Prospects for productivity in NATURE REVIEWS DRUG DISCOVERY
  • 2008-12. Market Watch : Pharma industry strategic performance: 2007–2012E in NATURE REVIEWS DRUG DISCOVERY
  • 2005-03. The Impact of New Drug Launches on Longevity: Evidence from Longitudinal, Disease-Level Data from 52 Countries, 1982–2001 in INTERNATIONAL JOURNAL OF HEALTH ECONOMICS AND MANAGEMENT
  • 2008-10. Market Watch: Pharma industry performance metrics: 2007–2012E in NATURE REVIEWS DRUG DISCOVERY
  • 2005-02. A guide to drug discovery: Pricing medicines: theory and practice, challenges and opportunities in NATURE REVIEWS DRUG DISCOVERY
  • 2002-09. The druggable genome in NATURE REVIEWS DRUG DISCOVERY
  • 2003-06. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia in NATURE GENETICS
  • Journal

    TITLE

    Nature Reviews Drug Discovery

    ISSUE

    3

    VOLUME

    9

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrd3078

    DOI

    http://dx.doi.org/10.1038/nrd3078

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016256401

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20168317


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