Aliskiren: the first renin inhibitor for clinical treatment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-05

AUTHORS

Chris Jensen, Peter Herold, Hans Rudolf Brunner

ABSTRACT

The first evidence of the existence of renin was presented over 100 years ago. However, the importance of renin and the renin-angiotensin system in the pathogenesis of cardiovascular disease was only fully realized in the 1970s. It was another 20 years before the first inhibitors of renin were available for clinical research. Here, we describe the discovery and development of aliskiren, an orally active renin inhibitor, which became the first drug in its class to receive regulatory approval. In 2007, it was approved for the treatment of hypertension by the US Food and Drug Administration and the European Medicines Agency. More... »

PAGES

399-410

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrd2550

DOI

http://dx.doi.org/10.1038/nrd2550

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053341882

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18340340


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antihypertensive Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cardiovascular Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fumarates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertension", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renin-Angiotensin System", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Speedel, Hirschg\u00e4sslein 11, Basel CH 4051, Switzerland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jensen", 
        "givenName": "Chris", 
        "id": "sg:person.0576117477.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576117477.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Speedel, Hirschg\u00e4sslein 11, Basel CH 4051, Switzerland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Herold", 
        "givenName": "Peter", 
        "id": "sg:person.0615610000.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615610000.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Speedel, Hirschg\u00e4sslein 11, Basel CH 4051, Switzerland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brunner", 
        "givenName": "Hans Rudolf", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s1074-5521(00)00134-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000148209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.83.4.1333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002637014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.99.3.275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003686244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.104.2.193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003990670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0033-0620(78)90024-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004093908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1291/hypres.25.57", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004358410", 
          "https://doi.org/10.1291/hypres.25.57"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1748-1716.1898.tb00272.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005049474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.2008.68", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005143548", 
          "https://doi.org/10.1038/ki.2008.68"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)61124-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006932955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.59.3.347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007428263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa011303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007722379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa011161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007846236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000182677.89816.38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008249388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000182677.89816.38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008249388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e3280103a6b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008697460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e3280103a6b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008697460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2125.1993.tb00413.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008767918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/dmd.106.013797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010586450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/299555a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010842288", 
          "https://doi.org/10.1038/299555a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2125.2006.02696.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010862064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200645110-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010932043", 
          "https://doi.org/10.2165/00003088-200645110-00006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000156466.02908.ed", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011488792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2125.1979.tb04692.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011795000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci21398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013749448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.289.19.2560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013958161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(03)01451-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014331776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(03)01451-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014331776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2215/cjn.01201005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014670898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1291/hypres.29.997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015117442", 
          "https://doi.org/10.1291/hypres.29.997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.328.7440.634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015645609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1002848402911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018578295", 
          "https://doi.org/10.1023/a:1002848402911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.15.6.835", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019456573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0091270006294404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019488117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs055293s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021068158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs055293s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021068158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000101688.17370.87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022762412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000101688.17370.87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022762412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.2001.0590041374.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022894632", 
          "https://doi.org/10.1046/j.1523-1755.2001.0590041374.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2188/jea.12.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023852187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00059-006-2829-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024664117", 
          "https://doi.org/10.1007/s00059-006-2829-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.16.7806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027840050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehi649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028781212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-8703(96)90365-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030394669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-1241.2006.01164.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030885580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.106.084301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031334286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.106.084301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031334286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.107.716555", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032402920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(82)90415-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032797394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ndt/gfl846", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032806588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.35.2.587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033535860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-6175.2007.06614.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033797783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2007050558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033859211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2007050558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033859211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3317/jraas.2007.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034317752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3317/jraas.2007.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034317752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000179573.91016.3f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034504396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000179573.91016.3f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034504396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10557-007-6069-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035694074", 
          "https://doi.org/10.1007/s10557-007-6069-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10557-007-6069-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035694074", 
          "https://doi.org/10.1007/s10557-007-6069-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0895-7061(96)00301-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036501829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200746080-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038052247", 
          "https://doi.org/10.2165/00003088-200746080-00003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200746080-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038052247", 
          "https://doi.org/10.2165/00003088-200746080-00003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199104183241605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040211370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-200502000-00025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040519047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-200502000-00025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040519047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/hrt.81.6.606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041403237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jhh.1001765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042230027", 
          "https://doi.org/10.1038/sj.jhh.1001765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jhh.1001765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042230027", 
          "https://doi.org/10.1038/sj.jhh.1001765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000131449.94713.ad", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042578417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3317/jraas.2000.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043129015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3317/jraas.2000.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043129015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199208000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044039410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199208000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044039410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000253780.36691.4f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044788646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000253780.36691.4f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044788646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(86)90274-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045199000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.81.16.5026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047188940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/clc.4950250810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048035793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.107.711374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048415715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.2042-7158.1994.tb03723.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048669675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1015886424586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048796561", 
          "https://doi.org/10.1023/a:1015886424586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.13.6.941", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050618661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hy0102.102293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053266836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0091270006297921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053417916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0895-7061(95)00340-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053745626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjhyper.2004.05.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054726723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjhyper.2007.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054728229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm070314y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055951174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm070314y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055951174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm070316i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055951176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm070316i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055951176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/15.suppl_d.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059574988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000146686.35541.29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000146686.35541.29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000146686.35541.29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2493678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062540329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.80.2.219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063341023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci14276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063415258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.15420/ecr.2006.0.2.17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067835394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074507170", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajh/5.12.243s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075329050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078307896", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081598011", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081625422", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082832642", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-05", 
    "datePublishedReg": "2008-05-01", 
    "description": "The first evidence of the existence of renin was presented over 100 years ago. However, the importance of renin and the renin-angiotensin system in the pathogenesis of cardiovascular disease was only fully realized in the 1970s. It was another 20 years before the first inhibitors of renin were available for clinical research. Here, we describe the discovery and development of aliskiren, an orally active renin inhibitor, which became the first drug in its class to receive regulatory approval. In 2007, it was approved for the treatment of hypertension by the US Food and Drug Administration and the European Medicines Agency.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nrd2550", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1327423", 
        "issn": [
          "1474-1776", 
          "1474-1784"
        ], 
        "name": "Nature Reviews Drug Discovery", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Aliskiren: the first renin inhibitor for clinical treatment", 
    "pagination": "399-410", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fe135deaaf4853b49385fb3c39b537ebba2ac13f8224bea926f17eac3ac28dd5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18340340"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101124171"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nrd2550"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1053341882"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nrd2550", 
      "https://app.dimensions.ai/details/publication/pub.1053341882"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/nrd2550"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrd2550'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrd2550'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrd2550'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrd2550'


 

This table displays all metadata directly associated to this object as RDF triples.

379 TRIPLES      21 PREDICATES      122 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nrd2550 schema:about N0acfd109f9d146e0b9850a6c7deb659e
2 N0e314aecd7b94189b40b4c90e767b637
3 N2af35a6437a947faac3cd3cf0563a908
4 N3fb0974186394b5ca05df9f00f1c4445
5 N6c3c5329d0bc46ad9de652b2ed914db2
6 N8d6f2dc0f8d244849b1049c6b804eb61
7 Na596a75fd0ac4c6cba736c9ccaddd68a
8 Nc93e52f754fe4ee688a762be97fb7cb2
9 anzsrc-for:11
10 anzsrc-for:1115
11 schema:author N852a25e0405547adade75d229f551aea
12 schema:citation sg:pub.10.1007/s00059-006-2829-3
13 sg:pub.10.1007/s10557-007-6069-4
14 sg:pub.10.1023/a:1002848402911
15 sg:pub.10.1023/a:1015886424586
16 sg:pub.10.1038/299555a0
17 sg:pub.10.1038/ki.2008.68
18 sg:pub.10.1038/sj.jhh.1001765
19 sg:pub.10.1046/j.1523-1755.2001.0590041374.x
20 sg:pub.10.1291/hypres.25.57
21 sg:pub.10.1291/hypres.29.997
22 sg:pub.10.2165/00003088-200645110-00006
23 sg:pub.10.2165/00003088-200746080-00003
24 https://app.dimensions.ai/details/publication/pub.1074507170
25 https://app.dimensions.ai/details/publication/pub.1078307896
26 https://app.dimensions.ai/details/publication/pub.1081598011
27 https://app.dimensions.ai/details/publication/pub.1081625422
28 https://app.dimensions.ai/details/publication/pub.1082832642
29 https://doi.org/10.1001/jama.289.19.2560
30 https://doi.org/10.1002/clc.4950250810
31 https://doi.org/10.1016/0002-9343(82)90415-6
32 https://doi.org/10.1016/0002-9343(86)90274-3
33 https://doi.org/10.1016/0033-0620(78)90024-5
34 https://doi.org/10.1016/0895-7061(95)00340-1
35 https://doi.org/10.1016/j.amjhyper.2004.05.017
36 https://doi.org/10.1016/j.amjhyper.2007.04.001
37 https://doi.org/10.1016/s0002-8703(96)90365-8
38 https://doi.org/10.1016/s0006-291x(03)01451-7
39 https://doi.org/10.1016/s0140-6736(07)61124-6
40 https://doi.org/10.1016/s0895-7061(96)00301-9
41 https://doi.org/10.1016/s1074-5521(00)00134-4
42 https://doi.org/10.1021/jm070314y
43 https://doi.org/10.1021/jm070316i
44 https://doi.org/10.1042/cs055293s
45 https://doi.org/10.1056/nejm199104183241605
46 https://doi.org/10.1056/nejmoa011161
47 https://doi.org/10.1056/nejmoa011303
48 https://doi.org/10.1073/pnas.81.16.5026
49 https://doi.org/10.1073/pnas.89.16.7806
50 https://doi.org/10.1084/jem.104.2.193
51 https://doi.org/10.1084/jem.59.3.347
52 https://doi.org/10.1084/jem.99.3.275
53 https://doi.org/10.1093/ajh/5.12.243s
54 https://doi.org/10.1093/eurheartj/15.suppl_d.113
55 https://doi.org/10.1093/eurheartj/ehi649
56 https://doi.org/10.1093/ndt/gfl846
57 https://doi.org/10.1097/00004872-199208000-00015
58 https://doi.org/10.1097/00004872-200502000-00025
59 https://doi.org/10.1097/01.asn.0000146686.35541.29
60 https://doi.org/10.1097/hjh.0b013e3280103a6b
61 https://doi.org/10.1111/j.1365-2125.1979.tb04692.x
62 https://doi.org/10.1111/j.1365-2125.1993.tb00413.x
63 https://doi.org/10.1111/j.1365-2125.2006.02696.x
64 https://doi.org/10.1111/j.1524-6175.2007.06614.x
65 https://doi.org/10.1111/j.1742-1241.2006.01164.x
66 https://doi.org/10.1111/j.1748-1716.1898.tb00272.x
67 https://doi.org/10.1111/j.2042-7158.1994.tb03723.x
68 https://doi.org/10.1124/dmd.106.013797
69 https://doi.org/10.1126/science.2493678
70 https://doi.org/10.1136/bmj.328.7440.634
71 https://doi.org/10.1136/hrt.81.6.606
72 https://doi.org/10.1161/01.cir.0000131449.94713.ad
73 https://doi.org/10.1161/01.cir.0000156466.02908.ed
74 https://doi.org/10.1161/01.cir.83.4.1333
75 https://doi.org/10.1161/01.hyp.0000101688.17370.87
76 https://doi.org/10.1161/01.hyp.0000179573.91016.3f
77 https://doi.org/10.1161/01.hyp.0000253780.36691.4f
78 https://doi.org/10.1161/01.hyp.13.6.941
79 https://doi.org/10.1161/01.hyp.15.6.835
80 https://doi.org/10.1161/01.hyp.35.2.587
81 https://doi.org/10.1161/01.res.0000182677.89816.38
82 https://doi.org/10.1161/01.res.80.2.219
83 https://doi.org/10.1161/circulationaha.107.711374
84 https://doi.org/10.1161/circulationaha.107.716555
85 https://doi.org/10.1161/hy0102.102293
86 https://doi.org/10.1161/hypertensionaha.106.084301
87 https://doi.org/10.1172/jci14276
88 https://doi.org/10.1172/jci21398
89 https://doi.org/10.1177/0091270006294404
90 https://doi.org/10.1177/0091270006297921
91 https://doi.org/10.15420/ecr.2006.0.2.17
92 https://doi.org/10.1681/asn.2007050558
93 https://doi.org/10.2188/jea.12.112
94 https://doi.org/10.2215/cjn.01201005
95 https://doi.org/10.3317/jraas.2000.018
96 https://doi.org/10.3317/jraas.2007.028
97 schema:datePublished 2008-05
98 schema:datePublishedReg 2008-05-01
99 schema:description The first evidence of the existence of renin was presented over 100 years ago. However, the importance of renin and the renin-angiotensin system in the pathogenesis of cardiovascular disease was only fully realized in the 1970s. It was another 20 years before the first inhibitors of renin were available for clinical research. Here, we describe the discovery and development of aliskiren, an orally active renin inhibitor, which became the first drug in its class to receive regulatory approval. In 2007, it was approved for the treatment of hypertension by the US Food and Drug Administration and the European Medicines Agency.
100 schema:genre research_article
101 schema:inLanguage en
102 schema:isAccessibleForFree false
103 schema:isPartOf N2fb28eeed2f74e1db1f952b4ecbb599a
104 N59e8a453729f4f0c89420d78b290d9af
105 sg:journal.1327423
106 schema:name Aliskiren: the first renin inhibitor for clinical treatment
107 schema:pagination 399-410
108 schema:productId N0dd623d2c9944c3780c10ec1c76c2a9f
109 N10dbf9f8f4364157952bca637c878acf
110 N36e780f7221345d0af101815eba8e1b7
111 N7481cff0131f4c158e4ea35c9f23ff4d
112 N92d2e0bf04f84ce193051a92ba7e683c
113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053341882
114 https://doi.org/10.1038/nrd2550
115 schema:sdDatePublished 2019-04-10T20:35
116 schema:sdLicense https://scigraph.springernature.com/explorer/license/
117 schema:sdPublisher N4fa689867d0942cd947f3c09f7500cd0
118 schema:url http://www.nature.com/articles/nrd2550
119 sgo:license sg:explorer/license/
120 sgo:sdDataset articles
121 rdf:type schema:ScholarlyArticle
122 N06773ba613c645e78d04f10d559914ef schema:name Speedel, Hirschgässlein 11, Basel CH 4051, Switzerland.
123 rdf:type schema:Organization
124 N0acfd109f9d146e0b9850a6c7deb659e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Hypertension
126 rdf:type schema:DefinedTerm
127 N0dd623d2c9944c3780c10ec1c76c2a9f schema:name nlm_unique_id
128 schema:value 101124171
129 rdf:type schema:PropertyValue
130 N0e314aecd7b94189b40b4c90e767b637 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Fumarates
132 rdf:type schema:DefinedTerm
133 N10dbf9f8f4364157952bca637c878acf schema:name doi
134 schema:value 10.1038/nrd2550
135 rdf:type schema:PropertyValue
136 N2af35a6437a947faac3cd3cf0563a908 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Humans
138 rdf:type schema:DefinedTerm
139 N2fb28eeed2f74e1db1f952b4ecbb599a schema:volumeNumber 7
140 rdf:type schema:PublicationVolume
141 N36e780f7221345d0af101815eba8e1b7 schema:name readcube_id
142 schema:value fe135deaaf4853b49385fb3c39b537ebba2ac13f8224bea926f17eac3ac28dd5
143 rdf:type schema:PropertyValue
144 N3fb0974186394b5ca05df9f00f1c4445 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Amides
146 rdf:type schema:DefinedTerm
147 N4fa689867d0942cd947f3c09f7500cd0 schema:name Springer Nature - SN SciGraph project
148 rdf:type schema:Organization
149 N59e8a453729f4f0c89420d78b290d9af schema:issueNumber 5
150 rdf:type schema:PublicationIssue
151 N5b5d59598f054afab05c1d1e124e3e5a schema:name Speedel, Hirschgässlein 11, Basel CH 4051, Switzerland.
152 rdf:type schema:Organization
153 N6c3c5329d0bc46ad9de652b2ed914db2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Antihypertensive Agents
155 rdf:type schema:DefinedTerm
156 N743f9384915c4bc0b77a437b6a1301f6 rdf:first sg:person.0615610000.71
157 rdf:rest Nfdc237390fe342c3b9640a0bd65d2c65
158 N7481cff0131f4c158e4ea35c9f23ff4d schema:name dimensions_id
159 schema:value pub.1053341882
160 rdf:type schema:PropertyValue
161 N790afc6b833b4359a9d21f983b1686b0 schema:name Speedel, Hirschgässlein 11, Basel CH 4051, Switzerland.
162 rdf:type schema:Organization
163 N852a25e0405547adade75d229f551aea rdf:first sg:person.0576117477.25
164 rdf:rest N743f9384915c4bc0b77a437b6a1301f6
165 N8d6f2dc0f8d244849b1049c6b804eb61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Renin-Angiotensin System
167 rdf:type schema:DefinedTerm
168 N92d2e0bf04f84ce193051a92ba7e683c schema:name pubmed_id
169 schema:value 18340340
170 rdf:type schema:PropertyValue
171 Na596a75fd0ac4c6cba736c9ccaddd68a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Cardiovascular Diseases
173 rdf:type schema:DefinedTerm
174 Nac5ff52593f74f77b73762951612f9a3 schema:affiliation N5b5d59598f054afab05c1d1e124e3e5a
175 schema:familyName Brunner
176 schema:givenName Hans Rudolf
177 rdf:type schema:Person
178 Nc93e52f754fe4ee688a762be97fb7cb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Renin
180 rdf:type schema:DefinedTerm
181 Nfdc237390fe342c3b9640a0bd65d2c65 rdf:first Nac5ff52593f74f77b73762951612f9a3
182 rdf:rest rdf:nil
183 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
184 schema:name Medical and Health Sciences
185 rdf:type schema:DefinedTerm
186 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
187 schema:name Pharmacology and Pharmaceutical Sciences
188 rdf:type schema:DefinedTerm
189 sg:journal.1327423 schema:issn 1474-1776
190 1474-1784
191 schema:name Nature Reviews Drug Discovery
192 rdf:type schema:Periodical
193 sg:person.0576117477.25 schema:affiliation N790afc6b833b4359a9d21f983b1686b0
194 schema:familyName Jensen
195 schema:givenName Chris
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576117477.25
197 rdf:type schema:Person
198 sg:person.0615610000.71 schema:affiliation N06773ba613c645e78d04f10d559914ef
199 schema:familyName Herold
200 schema:givenName Peter
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615610000.71
202 rdf:type schema:Person
203 sg:pub.10.1007/s00059-006-2829-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024664117
204 https://doi.org/10.1007/s00059-006-2829-3
205 rdf:type schema:CreativeWork
206 sg:pub.10.1007/s10557-007-6069-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035694074
207 https://doi.org/10.1007/s10557-007-6069-4
208 rdf:type schema:CreativeWork
209 sg:pub.10.1023/a:1002848402911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018578295
210 https://doi.org/10.1023/a:1002848402911
211 rdf:type schema:CreativeWork
212 sg:pub.10.1023/a:1015886424586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048796561
213 https://doi.org/10.1023/a:1015886424586
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/299555a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010842288
216 https://doi.org/10.1038/299555a0
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/ki.2008.68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005143548
219 https://doi.org/10.1038/ki.2008.68
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/sj.jhh.1001765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042230027
222 https://doi.org/10.1038/sj.jhh.1001765
223 rdf:type schema:CreativeWork
224 sg:pub.10.1046/j.1523-1755.2001.0590041374.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022894632
225 https://doi.org/10.1046/j.1523-1755.2001.0590041374.x
226 rdf:type schema:CreativeWork
227 sg:pub.10.1291/hypres.25.57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004358410
228 https://doi.org/10.1291/hypres.25.57
229 rdf:type schema:CreativeWork
230 sg:pub.10.1291/hypres.29.997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015117442
231 https://doi.org/10.1291/hypres.29.997
232 rdf:type schema:CreativeWork
233 sg:pub.10.2165/00003088-200645110-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010932043
234 https://doi.org/10.2165/00003088-200645110-00006
235 rdf:type schema:CreativeWork
236 sg:pub.10.2165/00003088-200746080-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038052247
237 https://doi.org/10.2165/00003088-200746080-00003
238 rdf:type schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1074507170 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1078307896 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1081598011 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1081625422 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1082832642 schema:CreativeWork
244 https://doi.org/10.1001/jama.289.19.2560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013958161
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1002/clc.4950250810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048035793
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/0002-9343(82)90415-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032797394
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/0002-9343(86)90274-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045199000
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/0033-0620(78)90024-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004093908
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/0895-7061(95)00340-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053745626
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.amjhyper.2004.05.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054726723
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.amjhyper.2007.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054728229
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/s0002-8703(96)90365-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030394669
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/s0006-291x(03)01451-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014331776
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/s0140-6736(07)61124-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006932955
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/s0895-7061(96)00301-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036501829
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/s1074-5521(00)00134-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000148209
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1021/jm070314y schema:sameAs https://app.dimensions.ai/details/publication/pub.1055951174
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1021/jm070316i schema:sameAs https://app.dimensions.ai/details/publication/pub.1055951176
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1042/cs055293s schema:sameAs https://app.dimensions.ai/details/publication/pub.1021068158
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1056/nejm199104183241605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040211370
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1056/nejmoa011161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007846236
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1056/nejmoa011303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007722379
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1073/pnas.81.16.5026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047188940
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1073/pnas.89.16.7806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027840050
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1084/jem.104.2.193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003990670
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1084/jem.59.3.347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007428263
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1084/jem.99.3.275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003686244
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1093/ajh/5.12.243s schema:sameAs https://app.dimensions.ai/details/publication/pub.1075329050
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1093/eurheartj/15.suppl_d.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059574988
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1093/eurheartj/ehi649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028781212
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1093/ndt/gfl846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032806588
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1097/00004872-199208000-00015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044039410
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1097/00004872-200502000-00025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040519047
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1097/01.asn.0000146686.35541.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060319802
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1097/hjh.0b013e3280103a6b schema:sameAs https://app.dimensions.ai/details/publication/pub.1008697460
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1111/j.1365-2125.1979.tb04692.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011795000
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1111/j.1365-2125.1993.tb00413.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008767918
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1111/j.1365-2125.2006.02696.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010862064
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1111/j.1524-6175.2007.06614.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033797783
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1111/j.1742-1241.2006.01164.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030885580
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1111/j.1748-1716.1898.tb00272.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005049474
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1111/j.2042-7158.1994.tb03723.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048669675
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1124/dmd.106.013797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010586450
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1126/science.2493678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062540329
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1136/bmj.328.7440.634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015645609
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1136/hrt.81.6.606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041403237
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1161/01.cir.0000131449.94713.ad schema:sameAs https://app.dimensions.ai/details/publication/pub.1042578417
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1161/01.cir.0000156466.02908.ed schema:sameAs https://app.dimensions.ai/details/publication/pub.1011488792
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1161/01.cir.83.4.1333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002637014
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1161/01.hyp.0000101688.17370.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022762412
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1161/01.hyp.0000179573.91016.3f schema:sameAs https://app.dimensions.ai/details/publication/pub.1034504396
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1161/01.hyp.0000253780.36691.4f schema:sameAs https://app.dimensions.ai/details/publication/pub.1044788646
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1161/01.hyp.13.6.941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050618661
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1161/01.hyp.15.6.835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019456573
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1161/01.hyp.35.2.587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033535860
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1161/01.res.0000182677.89816.38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008249388
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1161/01.res.80.2.219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063341023
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1161/circulationaha.107.711374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048415715
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1161/circulationaha.107.716555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032402920
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1161/hy0102.102293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053266836
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1161/hypertensionaha.106.084301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031334286
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1172/jci14276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063415258
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1172/jci21398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013749448
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1177/0091270006294404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019488117
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1177/0091270006297921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053417916
367 rdf:type schema:CreativeWork
368 https://doi.org/10.15420/ecr.2006.0.2.17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067835394
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1681/asn.2007050558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033859211
371 rdf:type schema:CreativeWork
372 https://doi.org/10.2188/jea.12.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023852187
373 rdf:type schema:CreativeWork
374 https://doi.org/10.2215/cjn.01201005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014670898
375 rdf:type schema:CreativeWork
376 https://doi.org/10.3317/jraas.2000.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043129015
377 rdf:type schema:CreativeWork
378 https://doi.org/10.3317/jraas.2007.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034317752
379 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...