The TWEAK–Fn14 cytokine–receptor axis: discovery, biology and therapeutic targeting View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-05

AUTHORS

Jeffrey A Winkles

ABSTRACT

TWEAK is a multifunctional cytokine that controls many cellular activities including proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK acts by binding to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-kappaB (NF-kappaB) pathway. The TWEAK-Fn14 axis normally regulates various physiological processes, in particular it seems to play an important, beneficial role in tissue repair following acute injury. Furthermore, recent studies have indicated that TWEAK-Fn14 axis signalling may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke. This Review provides an overview of TWEAK-Fn14 axis biology and summarizes the available data supporting the proposal that both TWEAK and Fn14 should be considered as potential targets for the development of novel therapeutics. More... »

PAGES

411-425

References to SciGraph publications

  • 2005-12. Immune cell migration in inflammation: present and future therapeutic targets in NATURE IMMUNOLOGY
  • 2003-01. The CD95(APO-1/Fas) DISC and beyond in CELL DEATH & DIFFERENTIATION
  • 2007-06. TWEAK and the Central Nervous System in MOLECULAR NEUROBIOLOGY
  • 2004-02. Cytokine–receptor pairing: accelerating discovery of cytokine function in NATURE REVIEWS DRUG DISCOVERY
  • 2006-07. Immunotoxin therapy of cancer in NATURE REVIEWS CANCER
  • 2007-01. Integrating cell-signalling pathways with NF-κB and IKK function in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2001-11. Proinflammatory activity of TWEAK on human dermal fibroblasts and synoviocytes: blocking and enhancing effects of anti-TWEAK monoclonal antibodies in ARTHRITIS RESEARCH & THERAPY
  • 2006-01. Paradoxical roles of the immune system during cancer development in NATURE REVIEWS CANCER
  • 2006-11. Cytokine cooperation in renal tubular cell injury: The role of TWEAK in KIDNEY INTERNATIONAL
  • 2006-11. TWEAK shall inherit the earth in CELL DEATH & DIFFERENTIATION
  • 2003-09. Molecular basis of angiogenesis and cancer in ONCOGENE
  • 2006-08. Tumor metastasis: mechanistic insights and clinical challenges in NATURE MEDICINE
  • 2004-05. Induction of RANTES by TWEAK/Fn14 Interaction in Human Keratinocytes in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2007-11. The origin and application of experimental autoimmune encephalomyelitis in NATURE REVIEWS IMMUNOLOGY
  • 2007-06. Cytokines in the pathogenesis of rheumatoid arthritis in NATURE REVIEWS IMMUNOLOGY
  • 2006-10. NF-κB and the immune response in ONCOGENE
  • 2003-06. Tumorigenesis and the angiogenic switch in NATURE REVIEWS CANCER
  • 2006-05. Nuclear factor-κB in cancer development and progression in NATURE
  • 2006-10. TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells in ARTHRITIS RESEARCH & THERAPY
  • 2006-06. Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis in ONCOGENE
  • 2002-12. Points of control in inflammation in NATURE
  • 2005-04. Tweak induces mammary epithelial branching morphogenesis in ONCOGENE
  • 2002-07. Angiogenesis in rheumatoid arthritis in ARTHRITIS RESEARCH & THERAPY
  • 2007-03. Inflammation in Wound Repair: Molecular and Cellular Mechanisms in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2002-12. Death of HT29 adenocarcinoma cells induced by TNF family receptor activation is caspase-independent and displays features of both apoptosis and necrosis in CELL DEATH & DIFFERENTIATION
  • Journal

    TITLE

    Nature Reviews Drug Discovery

    ISSUE

    5

    VOLUME

    7

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrd2488

    DOI

    http://dx.doi.org/10.1038/nrd2488

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009591893

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18404150


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