Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-11

AUTHORS

Russell A Wilke, Debbie W Lin, Dan M Roden, Paul B Watkins, David Flockhart, Issam Zineh, Kathleen M Giacomini, Ronald M Krauss

ABSTRACT

Serious adverse drug reactions (SADRs) are a major cause of morbidity and mortality worldwide. Some SADRs may be predictable, based upon a drug's pharmacodynamic and pharmacokinetic properties. Many, however, appear to be idiosyncratic. Genetic factors may underlie susceptibility to SADRs and the identification of predisposing genotypes may improve patient management through the prospective selection of appropriate candidates. Here we discuss three specific SADRs with an emphasis on genetic risk factors. These SADRs, selected based on wide-sweeping clinical interest, are drug-induced liver injury, statin-induced myotoxicity and drug-induced long QT and torsades de pointes. Key challenges for the discovery of predictive risk alleles for these SADRs are also considered. More... »

PAGES

904-916

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrd2423

    DOI

    http://dx.doi.org/10.1038/nrd2423

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041544141

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17971785


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