Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-09

AUTHORS

Jürgen Wess, Richard M. Eglen, Dinesh Gautam

ABSTRACT

Muscarinic acetylcholine receptors (mAChRs), M(1)-M(5), regulate the activity of numerous fundamental central and peripheral functions. The lack of small-molecule ligands that can block or activate specific mAChR subtypes with high selectivity has remained a major obstacle in defining the roles of the individual receptor subtypes and in the development of novel muscarinic drugs. Recently, phenotypic analysis of mutant mouse strains deficient in each of the five mAChR subtypes has led to a wealth of new information regarding the physiological roles of the individual receptor subtypes. Importantly, these studies have identified specific mAChR-regulated pathways as potentially novel targets for the treatment of various important disorders including Alzheimer's disease, schizophrenia, pain, obesity and diabetes. More... »

PAGES

721-733

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrd2379

DOI

http://dx.doi.org/10.1038/nrd2379

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037578170

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17762886


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