Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-01

AUTHORS

Kishor M Wasan, Dion R Brocks, Stephen D Lee, Kristina Sachs-Barrable, Sheila J Thornton

ABSTRACT

In contrast to many traditional pharmaceutical agents that exhibit a high degree of aqueous solubility, new drug candidates are frequently highly lipophilic compounds. The aqueous environment of the blood provides a thermodynamically unfavourable environment for the disposition of such hydrophobic drugs. However, this limitation can be overcome by association with circulating lipoproteins. Elucidation of the mechanisms that dictate drug-lipoprotein association and blood-to-tissue partitioning of lipoprotein encapsulated drugs might yield valuable insight into the factors governing the pharmacological activity and potential toxicity of these compounds. This Review discusses the impact of hydrophobic drug-lipoprotein interactions on pharmacokinetics, drug metabolism, tissue distribution and biological activity of various hydrophobic compounds, and outlines how best to use this information in drug discovery and development programmes. More... »

PAGES

84-99

References to SciGraph publications

  • 2006-12. Insights into the effects of hyperlipoproteinemia on cyclosporine A biodistribution and relationship to renal function in THE AAPS JOURNAL
  • 2006-07. Acute P-407 Administration to Mice Causes Hypercholesterolemia by Inducing Cholesterolgenesis and Down-Regulating Low-Density Lipoprotein Receptor Expression in PHARMACEUTICAL RESEARCH
  • 1990-09. Emerging Indications for the Use of Cyclosporin in Organ Transplantation and Autoimmunity in DRUGS
  • 1995-04. Effect of dietary fat on the pharmacokinetics and pharmacodynamics of cyclosporine in kidney transplant recipients in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2000-04. The Stereoselective Distribution of Halofantrine Enantiomers Within Human, Dog, and Rat Plasma Lipoproteins in PHARMACEUTICAL RESEARCH
  • 2004-04. Hypertriglyceridemia as an indicator of the severity of falciparum malaria in returned travelers: a clinical retrospective study in PARASITOLOGY RESEARCH
  • 2005-12. Hypertriglyceridemia as a possible risk factor for prostate cancer in PROSTATE CANCER AND PROSTATIC DISEASES
  • 1997-11. Differences in Lipoprotein Lipid Concentration and Composition Modify the Plasma Distribution of Cyclosporine in PHARMACEUTICAL RESEARCH
  • 2007-03. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs in NATURE REVIEWS DRUG DISCOVERY
  • 1999-07. Low density lipoprotein and liposome mediated uptake and cytotoxic effect of N4-octadecyl-1-β-D-arabinofuranosylcytosine in Daudi lymphoma cells in BRITISH JOURNAL OF CANCER
  • 1996-03. Differences in Lipoprotein Concentration and Composition Modify the Plasma Distribution of Free and Liposomal Annamycin in PHARMACEUTICAL RESEARCH
  • 1990-01. High-Fat Meals Increase the Clearance of Cyclosporine in PHARMACEUTICAL RESEARCH
  • 1999-07. Cyclosporine Transfer from Low- and High-Density Lipoproteins Is Partially Influenced by Lipid Transfer Protein I Triglyceride Transfer Activity in PHARMACEUTICAL RESEARCH
  • 2000-09. Serum lipoprotein profile in patients with cancer. A comparison with non-cancer subjects in INTERNATIONAL JOURNAL OF CLINICAL AND LABORATORY RESEARCH
  • 1997-10. Effects of Low and High Density Lipoproteins on Renal Cyclosporine A and Cyclosporine G Disposition in the Isolated Perfused Rat Kidney in PHARMACEUTICAL RESEARCH
  • 1998-12. Low-density lipoprotein receptor-mediated delivery of a lipophilic daunorubicin derivative to B16 tumours in mice using apolipoprotein E-enriched liposomes in BRITISH JOURNAL OF CANCER
  • 2001-07. LDL Induced Association of Anionic Liposomes with Cells and Delivery of Contents as Shown by the Increase in Potency of Liposome Dependent Drugs in PHARMACEUTICAL RESEARCH
  • 2001-03. Lipophilicity in PK design: methyl, ethyl, futile in JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
  • 2005-03. HDL as a target in the treatment of atherosclerotic cardiovascular disease in NATURE REVIEWS DRUG DISCOVERY
  • 1999-02. Effects of Hyperlipidemia on the Pharmacokinetics of Nifedipine in the Rat in PHARMACEUTICAL RESEARCH
  • 2007-02. Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2006-07. Primer: histopathology of calcineurin-inhibitor toxicity in renal allografts in NATURE REVIEWS NEPHROLOGY
  • 1999-10. Lipoprotein receptors: new roles for ancient proteins in NATURE CELL BIOLOGY
  • 1975-08. Lipoprotein receptors and the genetic control of cholesterol metabolism in cultured human cells in THE SCIENCE OF NATURE
  • 1998-04. Synthesis of a Lipophilic Daunoruhicin Derivative and Its Incorporation into Lipidic Carriers Developed for LDL Receptor-Mediated Tumor Therapy in PHARMACEUTICAL RESEARCH
  • 2000-10. Apolipoprotein E receptors: linking brain development and alzheimer's disease in NATURE REVIEWS NEUROSCIENCE
  • 2007-04. The Influence of Hyperlipoproteinemia on in Vitro Distribution of Amiodarone and Desethylamiodarone in Human and Rat Plasma in PHARMACEUTICAL RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrd2353

    DOI

    http://dx.doi.org/10.1038/nrd2353

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1011926113

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18079757


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Pharmacology and Pharmaceutical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Design", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lipoproteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pharmaceutical Preparations", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Conformation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, LDL", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada V6T 1Z3. kwasan@interchange.ubc.ca"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wasan", 
            "givenName": "Kishor M", 
            "id": "sg:person.0666655515.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666655515.32"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Brocks", 
            "givenName": "Dion R", 
            "id": "sg:person.0771107563.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771107563.46"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Lee", 
            "givenName": "Stephen D", 
            "id": "sg:person.01053604330.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053604330.29"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Sachs-Barrable", 
            "givenName": "Kristina", 
            "id": "sg:person.01005471130.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005471130.92"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Thornton", 
            "givenName": "Sheila J", 
            "id": "sg:person.0652157560.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652157560.70"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1128/aac.48.9.3233-3240.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000019595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.38.9.2224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000494465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1520-6017(200102)90:2<124::aid-jps3>3.0.co;2-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000556179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1520-6017(200102)90:2<124::aid-jps3>3.0.co;2-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000556179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1081/ddc-54305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001434856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1081/ddc-54305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001434856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0009-9120(96)00001-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001435331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/00912709922008498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001506123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jps.1092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001934486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-199040030-00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001965472", 
              "https://doi.org/10.2165/00003495-199040030-00001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jps.10075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002227111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0300-9084(85)80051-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002665430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003326546", 
              "https://doi.org/10.1038/nrd2197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci118176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004119916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2125.1989.tb03507.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004356471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jps.10249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005671107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jps.10249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005671107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1468-1293.2005.00273.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005936317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.75.7.3445", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006001833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncpneph0225", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006086068", 
              "https://doi.org/10.1038/ncpneph0225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncpneph0225", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006086068", 
              "https://doi.org/10.1038/ncpneph0225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1007524919865", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006924689", 
              "https://doi.org/10.1023/a:1007524919865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1015831408425", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006962937", 
              "https://doi.org/10.1023/a:1015831408425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111764200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006992714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djh216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007072140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bdd.457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007870621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bdd.457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007870621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1875-9114.1991.tb04290.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007919955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jps.1083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008349879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0025-6196(12)64916-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009447090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.atherosclerosis.2006.06.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009471639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2796.1990.tb00136.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010060485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2796.1990.tb00136.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010060485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.89.10.4471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010161575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jps.10182", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010252140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/js9704846", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012161021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(86)90254-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012543292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(86)90254-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012543292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1194/jlr.d500033-jlr200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013013671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biochem.74.082803.133354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013414280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-03-0675", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013980246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-003-1012-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014369567", 
              "https://doi.org/10.1007/s00436-003-1012-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-003-1012-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014369567", 
              "https://doi.org/10.1007/s00436-003-1012-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6690558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014496843", 
              "https://doi.org/10.1038/sj.bjc.6690558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6690558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014496843", 
              "https://doi.org/10.1038/sj.bjc.6690558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/14109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015839208", 
              "https://doi.org/10.1038/14109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/14109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015839208", 
              "https://doi.org/10.1038/14109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11095-006-9186-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015904974", 
              "https://doi.org/10.1007/s11095-006-9186-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci30163", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016261835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.107.142570", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016402146"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.107.142570", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016402146"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1054/clnu.2000.0151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016433118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm198710013171404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016706912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.1965.tb34810.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017298485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00007691-199308000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017486264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00007691-199308000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017486264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00007691-199308000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017486264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/0009-9236(95)90212-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017495934", 
              "https://doi.org/10.1016/0009-9236(95)90212-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1473-3099(03)00801-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017529024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1211/0022357021779104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017585671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.tp.0000074310.40484.94", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018437036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.tp.0000074310.40484.94", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018437036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(88)92538-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018723491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(88)92538-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018723491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35036221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018866968", 
              "https://doi.org/10.1038/35036221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35036221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018866968", 
              "https://doi.org/10.1038/35036221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1552-4604.1990.tb01868.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019123530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.105.593855", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019634079"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci107989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019714325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0021-9150(87)90106-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020907207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/js990101z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021800127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1010971808006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022874918", 
              "https://doi.org/10.1023/a:1010971808006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.35.5.713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023729868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.10.4431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025489043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1208/aapsj080477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025565916", 
              "https://doi.org/10.1208/aapsj080477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.37.2.246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025875716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1520-6017(200008)89:8<1022::aid-jps6>3.0.co;2-o", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026389798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1008192010023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027150724", 
              "https://doi.org/10.1023/a:1008192010023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1998.730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029434997", 
              "https://doi.org/10.1038/bjc.1998.730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1998.730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029434997", 
              "https://doi.org/10.1038/bjc.1998.730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000184795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029596778"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11095-006-0276-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029600074", 
              "https://doi.org/10.1007/s11095-006-0276-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(87)90510-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029811213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1432-1033.1995.tb20795.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030149412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.38.2.223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030153376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0163-4453(94)95986-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030847662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0005-2736(83)90236-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031667820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0005-2736(83)90236-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031667820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci116663", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032092024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb1197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032101297", 
              "https://doi.org/10.1038/nsmb1197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1359/jbmr.041102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032192741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bdd.2510120607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032203640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00007890-200103150-00014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032486553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00007890-200103150-00014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032486553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.2000.2441", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032928267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/js980152g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033164676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1016065114515", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033257526", 
              "https://doi.org/10.1023/a:1016065114515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bdd.357", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033307842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1018991917799", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034706898", 
              "https://doi.org/10.1023/a:1018991917799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109959200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035319550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci118149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035862876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1011917508056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035872806", 
              "https://doi.org/10.1023/a:1011917508056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1248/bpb.24.579", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035996421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.trim.2006.09.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036878120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/js980353k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038241552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa070635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038834066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000154144.73236.f4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039997135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000154144.73236.f4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039997135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1098-3597(05)80065-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040125991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.pa.23.040183.001511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040921276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(92)90643-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041239658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(92)90643-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041239658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0005-2760(78)90163-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041738802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0005-2760(78)90163-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041738802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s005990070013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041901871", 
              "https://doi.org/10.1007/s005990070013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s005990070013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041901871", 
              "https://doi.org/10.1007/s005990070013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(99)01731-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041944499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/js950472p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042057431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jps.2600830716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042881618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042882951", 
              "https://doi.org/10.1038/nrd1658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042882951", 
              "https://doi.org/10.1038/nrd1658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0962-8924(02)02282-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042945879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.87.7.2598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043290552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/07853890701214881", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043781741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0140-6736(92)90707-a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044045864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0140-6736(92)90707-a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044045864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1012190620854", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044600337", 
              "https://doi.org/10.1023/a:1012190620854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00625346", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044659119", 
              "https://doi.org/10.1007/bf00625346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/js970407a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044713147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1399-5618.2004.00156.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045418093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bdd.476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045618218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bdd.476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045618218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1875-9114.1995.tb04336.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045699562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1012141309951", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045783205", 
              "https://doi.org/10.1023/a:1012141309951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(85)92679-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047119172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-3659(01)00278-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048061560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.21.9725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048730479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m504678200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048931242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(75)90182-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048994991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1432-1033.1978.tb12534.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049174723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3490559", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049320695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3490559", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049320695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0010-7824(79)80029-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049336272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.pcan.4500834", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049875560", 
              "https://doi.org/10.1038/sj.pcan.4500834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.pcan.4500834", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049875560", 
              "https://doi.org/10.1038/sj.pcan.4500834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-2952(01)00708-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049880638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.2042-7158.1986.tb03085.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050104802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.addr.2003.12.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050307976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00007691-199107000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051578572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00007691-199107000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051578572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.45.4.1184-1191.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052742368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1248/bpb.24.683", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052785349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1018896912889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052848399", 
              "https://doi.org/10.1023/a:1018896912889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/cclm.1993.31.10.633", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053629124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi052535g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055201545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi052535g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055201545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/0264-6021:3490559", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056714885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/00034983.1992.11812715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058265338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/302365", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058609942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/clinids/14.supplement_1.s154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059472171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005344-199912000-00010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060206853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005344-199912000-00010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060206853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005344-199912000-00010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060206853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005768-199711000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060228312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005768-199711000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060228312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005768-199711000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060228312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.271.5248.518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062552090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3513311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062618548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3513311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062618548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.hyp.19.1_suppl.i110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063338783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci13992", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063416141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1176/appi.ajp.158.6.949", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063493920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/endo-105-3-605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064254412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2007-0275", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064289882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.74.5.1045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064296270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.76.6.1423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064296888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jcem.74.5.1373735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064317511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3949/ccjm.72.12.1113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071759836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4088/jcp.1106e16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072205124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4088/jcp.v60n0602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072207418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4088/jcp.v66n0503", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072209135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4088/jcp.v67n0704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072209534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074268023", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074522744", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074630345", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajprenal.2001.281.2.f337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074850598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.21236/ada408103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075105015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075337220", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075840489", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076627936", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076630230", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076819854", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajhp/61.6.565", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076819854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajhp/61.6.565", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076819854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajhp/61.6.565", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076819854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076881130", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077130917", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077412179", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078021184", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078592105", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078783408", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079428827", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079553452", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079608913", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079666990", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079697043", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079704924", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080089109", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081953728", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081979007", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081984625", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082396501", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082766977", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082794727", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082967664", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mol.52.3.445", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083140502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.41.9.1871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083149466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083154725", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083207457", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.42.8.1878", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083299280"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2008-01", 
        "datePublishedReg": "2008-01-01", 
        "description": "In contrast to many traditional pharmaceutical agents that exhibit a high degree of aqueous solubility, new drug candidates are frequently highly lipophilic compounds. The aqueous environment of the blood provides a thermodynamically unfavourable environment for the disposition of such hydrophobic drugs. However, this limitation can be overcome by association with circulating lipoproteins. Elucidation of the mechanisms that dictate drug-lipoprotein association and blood-to-tissue partitioning of lipoprotein encapsulated drugs might yield valuable insight into the factors governing the pharmacological activity and potential toxicity of these compounds. This Review discusses the impact of hydrophobic drug-lipoprotein interactions on pharmacokinetics, drug metabolism, tissue distribution and biological activity of various hydrophobic compounds, and outlines how best to use this information in drug discovery and development programmes.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nrd2353", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1327423", 
            "issn": [
              "1474-1776", 
              "1474-1784"
            ], 
            "name": "Nature Reviews Drug Discovery", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "7"
          }
        ], 
        "name": "Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery", 
        "pagination": "84-99", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "38d27e7e7837091377c23edf22d0510e98eae1556d8a0665f4bc471527be133b"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "18079757"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101124171"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrd2353"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1011926113"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrd2353", 
          "https://app.dimensions.ai/details/publication/pub.1011926113"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:55", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000422.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/nrd/journal/v7/n1/full/nrd2353.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrd2353'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrd2353'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrd2353'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrd2353'


     

    This table displays all metadata directly associated to this object as RDF triples.

    667 TRIPLES      21 PREDICATES      219 URIs      28 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrd2353 schema:about N0cda2d7c997d44699d658b7628253be8
    2 N1014ed81509a4262b3846e6877de1b4b
    3 N8758c67a3b53431abc011e045b6e9f09
    4 N998fba377c8d466c9eb7afc9ae295235
    5 Nb0579667264640aab9db9d19759d7bd3
    6 Ncbb08ff78d814367979436979a194a61
    7 Ne67c7af591bf40eead50f0546e32e7f2
    8 anzsrc-for:11
    9 anzsrc-for:1115
    10 schema:author N5b4370dc3bc6467ba81067c8593415fe
    11 schema:citation sg:pub.10.1007/bf00625346
    12 sg:pub.10.1007/s00436-003-1012-5
    13 sg:pub.10.1007/s005990070013
    14 sg:pub.10.1007/s11095-006-0276-8
    15 sg:pub.10.1007/s11095-006-9186-z
    16 sg:pub.10.1016/0009-9236(95)90212-0
    17 sg:pub.10.1023/a:1007524919865
    18 sg:pub.10.1023/a:1008192010023
    19 sg:pub.10.1023/a:1010971808006
    20 sg:pub.10.1023/a:1011917508056
    21 sg:pub.10.1023/a:1012141309951
    22 sg:pub.10.1023/a:1012190620854
    23 sg:pub.10.1023/a:1015831408425
    24 sg:pub.10.1023/a:1016065114515
    25 sg:pub.10.1023/a:1018896912889
    26 sg:pub.10.1023/a:1018991917799
    27 sg:pub.10.1038/14109
    28 sg:pub.10.1038/35036221
    29 sg:pub.10.1038/bjc.1998.730
    30 sg:pub.10.1038/ncpneph0225
    31 sg:pub.10.1038/nrd1658
    32 sg:pub.10.1038/nrd2197
    33 sg:pub.10.1038/nsmb1197
    34 sg:pub.10.1038/sj.bjc.6690558
    35 sg:pub.10.1038/sj.pcan.4500834
    36 sg:pub.10.1208/aapsj080477
    37 sg:pub.10.2165/00003495-199040030-00001
    38 https://app.dimensions.ai/details/publication/pub.1074268023
    39 https://app.dimensions.ai/details/publication/pub.1074522744
    40 https://app.dimensions.ai/details/publication/pub.1074630345
    41 https://app.dimensions.ai/details/publication/pub.1075337220
    42 https://app.dimensions.ai/details/publication/pub.1075840489
    43 https://app.dimensions.ai/details/publication/pub.1076627936
    44 https://app.dimensions.ai/details/publication/pub.1076630230
    45 https://app.dimensions.ai/details/publication/pub.1076819854
    46 https://app.dimensions.ai/details/publication/pub.1076881130
    47 https://app.dimensions.ai/details/publication/pub.1077130917
    48 https://app.dimensions.ai/details/publication/pub.1077412179
    49 https://app.dimensions.ai/details/publication/pub.1078021184
    50 https://app.dimensions.ai/details/publication/pub.1078592105
    51 https://app.dimensions.ai/details/publication/pub.1078783408
    52 https://app.dimensions.ai/details/publication/pub.1079428827
    53 https://app.dimensions.ai/details/publication/pub.1079553452
    54 https://app.dimensions.ai/details/publication/pub.1079608913
    55 https://app.dimensions.ai/details/publication/pub.1079666990
    56 https://app.dimensions.ai/details/publication/pub.1079697043
    57 https://app.dimensions.ai/details/publication/pub.1079704924
    58 https://app.dimensions.ai/details/publication/pub.1080089109
    59 https://app.dimensions.ai/details/publication/pub.1081953728
    60 https://app.dimensions.ai/details/publication/pub.1081979007
    61 https://app.dimensions.ai/details/publication/pub.1081984625
    62 https://app.dimensions.ai/details/publication/pub.1082396501
    63 https://app.dimensions.ai/details/publication/pub.1082766977
    64 https://app.dimensions.ai/details/publication/pub.1082794727
    65 https://app.dimensions.ai/details/publication/pub.1082967664
    66 https://app.dimensions.ai/details/publication/pub.1083154725
    67 https://app.dimensions.ai/details/publication/pub.1083207457
    68 https://doi.org/10.1002/1520-6017(200008)89:8<1022::aid-jps6>3.0.co;2-o
    69 https://doi.org/10.1002/1520-6017(200102)90:2<124::aid-jps3>3.0.co;2-x
    70 https://doi.org/10.1002/bdd.2510120607
    71 https://doi.org/10.1002/bdd.357
    72 https://doi.org/10.1002/bdd.457
    73 https://doi.org/10.1002/bdd.476
    74 https://doi.org/10.1002/j.1552-4604.1990.tb01868.x
    75 https://doi.org/10.1002/j.1875-9114.1991.tb04290.x
    76 https://doi.org/10.1002/j.1875-9114.1995.tb04336.x
    77 https://doi.org/10.1002/jps.10075
    78 https://doi.org/10.1002/jps.10182
    79 https://doi.org/10.1002/jps.10249
    80 https://doi.org/10.1002/jps.1083
    81 https://doi.org/10.1002/jps.1092
    82 https://doi.org/10.1002/jps.2600830716
    83 https://doi.org/10.1006/bbrc.2000.2441
    84 https://doi.org/10.1016/0005-2736(83)90236-5
    85 https://doi.org/10.1016/0005-2760(78)90163-7
    86 https://doi.org/10.1016/0006-2952(92)90643-w
    87 https://doi.org/10.1016/0009-9120(96)00001-x
    88 https://doi.org/10.1016/0021-9150(87)90106-7
    89 https://doi.org/10.1016/0092-8674(75)90182-8
    90 https://doi.org/10.1016/0092-8674(87)90510-1
    91 https://doi.org/10.1016/0140-6736(92)90707-a
    92 https://doi.org/10.1016/j.addr.2003.12.003
    93 https://doi.org/10.1016/j.atherosclerosis.2006.06.030
    94 https://doi.org/10.1016/j.trim.2006.09.018
    95 https://doi.org/10.1016/s0006-2952(01)00708-0
    96 https://doi.org/10.1016/s0010-7824(79)80029-3
    97 https://doi.org/10.1016/s0014-5793(99)01731-7
    98 https://doi.org/10.1016/s0025-6196(12)64916-7
    99 https://doi.org/10.1016/s0140-6736(85)92679-0
    100 https://doi.org/10.1016/s0140-6736(86)90254-0
    101 https://doi.org/10.1016/s0140-6736(88)92538-x
    102 https://doi.org/10.1016/s0163-4453(94)95986-2
    103 https://doi.org/10.1016/s0168-3659(01)00278-4
    104 https://doi.org/10.1016/s0300-9084(85)80051-1
    105 https://doi.org/10.1016/s0962-8924(02)02282-1
    106 https://doi.org/10.1016/s1098-3597(05)80065-1
    107 https://doi.org/10.1016/s1473-3099(03)00801-6
    108 https://doi.org/10.1021/bi052535g
    109 https://doi.org/10.1021/js950472p
    110 https://doi.org/10.1021/js970407a
    111 https://doi.org/10.1021/js9704846
    112 https://doi.org/10.1021/js980152g
    113 https://doi.org/10.1021/js980353k
    114 https://doi.org/10.1021/js990101z
    115 https://doi.org/10.1042/0264-6021:3490559
    116 https://doi.org/10.1042/bj3490559
    117 https://doi.org/10.1054/clnu.2000.0151
    118 https://doi.org/10.1056/nejm198710013171404
    119 https://doi.org/10.1056/nejmoa070635
    120 https://doi.org/10.1073/pnas.75.7.3445
    121 https://doi.org/10.1073/pnas.87.7.2598
    122 https://doi.org/10.1073/pnas.89.10.4471
    123 https://doi.org/10.1073/pnas.91.10.4431
    124 https://doi.org/10.1073/pnas.91.21.9725
    125 https://doi.org/10.1074/jbc.m109959200
    126 https://doi.org/10.1074/jbc.m111764200
    127 https://doi.org/10.1074/jbc.m504678200
    128 https://doi.org/10.1080/00034983.1992.11812715
    129 https://doi.org/10.1080/07853890701214881
    130 https://doi.org/10.1081/ddc-54305
    131 https://doi.org/10.1086/302365
    132 https://doi.org/10.1093/ajhp/61.6.565
    133 https://doi.org/10.1093/clinids/14.supplement_1.s154
    134 https://doi.org/10.1093/jnci/djh216
    135 https://doi.org/10.1097/00005344-199912000-00010
    136 https://doi.org/10.1097/00005768-199711000-00005
    137 https://doi.org/10.1097/00007691-199107000-00002
    138 https://doi.org/10.1097/00007691-199308000-00003
    139 https://doi.org/10.1097/00007890-200103150-00014
    140 https://doi.org/10.1097/01.tp.0000074310.40484.94
    141 https://doi.org/10.1111/j.1365-2125.1989.tb03507.x
    142 https://doi.org/10.1111/j.1365-2796.1990.tb00136.x
    143 https://doi.org/10.1111/j.1399-5618.2004.00156.x
    144 https://doi.org/10.1111/j.1432-1033.1978.tb12534.x
    145 https://doi.org/10.1111/j.1432-1033.1995.tb20795.x
    146 https://doi.org/10.1111/j.1468-1293.2005.00273.x
    147 https://doi.org/10.1111/j.1749-6632.1965.tb34810.x
    148 https://doi.org/10.1111/j.2042-7158.1986.tb03085.x
    149 https://doi.org/10.1124/mol.52.3.445
    150 https://doi.org/10.1126/science.271.5248.518
    151 https://doi.org/10.1126/science.3513311
    152 https://doi.org/10.1128/aac.37.2.246
    153 https://doi.org/10.1128/aac.38.2.223
    154 https://doi.org/10.1128/aac.38.9.2224
    155 https://doi.org/10.1128/aac.41.9.1871
    156 https://doi.org/10.1128/aac.42.8.1878
    157 https://doi.org/10.1128/aac.45.4.1184-1191.2001
    158 https://doi.org/10.1128/aac.48.9.3233-3240.2004
    159 https://doi.org/10.1146/annurev.biochem.74.082803.133354
    160 https://doi.org/10.1146/annurev.pa.23.040183.001511
    161 https://doi.org/10.1152/ajprenal.2001.281.2.f337
    162 https://doi.org/10.1158/0008-5472.can-03-0675
    163 https://doi.org/10.1159/000184795
    164 https://doi.org/10.1161/01.atv.0000154144.73236.f4
    165 https://doi.org/10.1161/01.hyp.19.1_suppl.i110
    166 https://doi.org/10.1161/01.res.35.5.713
    167 https://doi.org/10.1161/atvbaha.107.142570
    168 https://doi.org/10.1161/circulationaha.105.593855
    169 https://doi.org/10.1172/jci107989
    170 https://doi.org/10.1172/jci116663
    171 https://doi.org/10.1172/jci118149
    172 https://doi.org/10.1172/jci118176
    173 https://doi.org/10.1172/jci13992
    174 https://doi.org/10.1172/jci30163
    175 https://doi.org/10.1176/appi.ajp.158.6.949
    176 https://doi.org/10.1177/00912709922008498
    177 https://doi.org/10.1194/jlr.d500033-jlr200
    178 https://doi.org/10.1210/endo-105-3-605
    179 https://doi.org/10.1210/jc.2007-0275
    180 https://doi.org/10.1210/jc.74.5.1045
    181 https://doi.org/10.1210/jc.76.6.1423
    182 https://doi.org/10.1210/jcem.74.5.1373735
    183 https://doi.org/10.1211/0022357021779104
    184 https://doi.org/10.1248/bpb.24.579
    185 https://doi.org/10.1248/bpb.24.683
    186 https://doi.org/10.1359/jbmr.041102
    187 https://doi.org/10.1515/cclm.1993.31.10.633
    188 https://doi.org/10.21236/ada408103
    189 https://doi.org/10.3949/ccjm.72.12.1113
    190 https://doi.org/10.4088/jcp.1106e16
    191 https://doi.org/10.4088/jcp.v60n0602
    192 https://doi.org/10.4088/jcp.v66n0503
    193 https://doi.org/10.4088/jcp.v67n0704
    194 schema:datePublished 2008-01
    195 schema:datePublishedReg 2008-01-01
    196 schema:description In contrast to many traditional pharmaceutical agents that exhibit a high degree of aqueous solubility, new drug candidates are frequently highly lipophilic compounds. The aqueous environment of the blood provides a thermodynamically unfavourable environment for the disposition of such hydrophobic drugs. However, this limitation can be overcome by association with circulating lipoproteins. Elucidation of the mechanisms that dictate drug-lipoprotein association and blood-to-tissue partitioning of lipoprotein encapsulated drugs might yield valuable insight into the factors governing the pharmacological activity and potential toxicity of these compounds. This Review discusses the impact of hydrophobic drug-lipoprotein interactions on pharmacokinetics, drug metabolism, tissue distribution and biological activity of various hydrophobic compounds, and outlines how best to use this information in drug discovery and development programmes.
    197 schema:genre research_article
    198 schema:inLanguage en
    199 schema:isAccessibleForFree false
    200 schema:isPartOf N051f112c352e4b9281d4b0148e5420e3
    201 N56da9b3662bd43b48f70c52d2857c437
    202 sg:journal.1327423
    203 schema:name Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery
    204 schema:pagination 84-99
    205 schema:productId N174b9ab365614fe78646796790801560
    206 N3b3a0d03d9d344b88f9541075d8681d9
    207 N7766bce04d3f4f509cd67d436af383f7
    208 Nb2cf63f734074c8f9c57f5fbad640716
    209 Nec8e874ec0b348919573ba64aa83a40b
    210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011926113
    211 https://doi.org/10.1038/nrd2353
    212 schema:sdDatePublished 2019-04-10T13:55
    213 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    214 schema:sdPublisher Nd07c856ef83340409e96b943dfad2190
    215 schema:url http://www.nature.com/nrd/journal/v7/n1/full/nrd2353.html
    216 sgo:license sg:explorer/license/
    217 sgo:sdDataset articles
    218 rdf:type schema:ScholarlyArticle
    219 N051f112c352e4b9281d4b0148e5420e3 schema:volumeNumber 7
    220 rdf:type schema:PublicationVolume
    221 N0cda2d7c997d44699d658b7628253be8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    222 schema:name Pharmaceutical Preparations
    223 rdf:type schema:DefinedTerm
    224 N0f9659b344c148aeaec21d42a42700e9 rdf:first sg:person.0771107563.46
    225 rdf:rest N31aacc2cb5d64375afb970073d398485
    226 N1014ed81509a4262b3846e6877de1b4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    227 schema:name Receptors, LDL
    228 rdf:type schema:DefinedTerm
    229 N174b9ab365614fe78646796790801560 schema:name doi
    230 schema:value 10.1038/nrd2353
    231 rdf:type schema:PropertyValue
    232 N31aacc2cb5d64375afb970073d398485 rdf:first sg:person.01053604330.29
    233 rdf:rest N4051ec4ff5db479eb60137d571a6b6f8
    234 N3b3a0d03d9d344b88f9541075d8681d9 schema:name nlm_unique_id
    235 schema:value 101124171
    236 rdf:type schema:PropertyValue
    237 N4051ec4ff5db479eb60137d571a6b6f8 rdf:first sg:person.01005471130.92
    238 rdf:rest N8f1a0a63de654fc4b79261b0ee9043ad
    239 N56da9b3662bd43b48f70c52d2857c437 schema:issueNumber 1
    240 rdf:type schema:PublicationIssue
    241 N5b4370dc3bc6467ba81067c8593415fe rdf:first sg:person.0666655515.32
    242 rdf:rest N0f9659b344c148aeaec21d42a42700e9
    243 N7766bce04d3f4f509cd67d436af383f7 schema:name pubmed_id
    244 schema:value 18079757
    245 rdf:type schema:PropertyValue
    246 N8758c67a3b53431abc011e045b6e9f09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    247 schema:name Drug Therapy
    248 rdf:type schema:DefinedTerm
    249 N8f1a0a63de654fc4b79261b0ee9043ad rdf:first sg:person.0652157560.70
    250 rdf:rest rdf:nil
    251 N998fba377c8d466c9eb7afc9ae295235 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    252 schema:name Drug Design
    253 rdf:type schema:DefinedTerm
    254 Nb0579667264640aab9db9d19759d7bd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    255 schema:name Humans
    256 rdf:type schema:DefinedTerm
    257 Nb2cf63f734074c8f9c57f5fbad640716 schema:name dimensions_id
    258 schema:value pub.1011926113
    259 rdf:type schema:PropertyValue
    260 Ncbb08ff78d814367979436979a194a61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    261 schema:name Lipoproteins
    262 rdf:type schema:DefinedTerm
    263 Nd07c856ef83340409e96b943dfad2190 schema:name Springer Nature - SN SciGraph project
    264 rdf:type schema:Organization
    265 Ne67c7af591bf40eead50f0546e32e7f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    266 schema:name Protein Conformation
    267 rdf:type schema:DefinedTerm
    268 Nec8e874ec0b348919573ba64aa83a40b schema:name readcube_id
    269 schema:value 38d27e7e7837091377c23edf22d0510e98eae1556d8a0665f4bc471527be133b
    270 rdf:type schema:PropertyValue
    271 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    272 schema:name Medical and Health Sciences
    273 rdf:type schema:DefinedTerm
    274 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
    275 schema:name Pharmacology and Pharmaceutical Sciences
    276 rdf:type schema:DefinedTerm
    277 sg:journal.1327423 schema:issn 1474-1776
    278 1474-1784
    279 schema:name Nature Reviews Drug Discovery
    280 rdf:type schema:Periodical
    281 sg:person.01005471130.92 schema:familyName Sachs-Barrable
    282 schema:givenName Kristina
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005471130.92
    284 rdf:type schema:Person
    285 sg:person.01053604330.29 schema:familyName Lee
    286 schema:givenName Stephen D
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053604330.29
    288 rdf:type schema:Person
    289 sg:person.0652157560.70 schema:familyName Thornton
    290 schema:givenName Sheila J
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652157560.70
    292 rdf:type schema:Person
    293 sg:person.0666655515.32 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    294 schema:familyName Wasan
    295 schema:givenName Kishor M
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666655515.32
    297 rdf:type schema:Person
    298 sg:person.0771107563.46 schema:familyName Brocks
    299 schema:givenName Dion R
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771107563.46
    301 rdf:type schema:Person
    302 sg:pub.10.1007/bf00625346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044659119
    303 https://doi.org/10.1007/bf00625346
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1007/s00436-003-1012-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014369567
    306 https://doi.org/10.1007/s00436-003-1012-5
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1007/s005990070013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041901871
    309 https://doi.org/10.1007/s005990070013
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1007/s11095-006-0276-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029600074
    312 https://doi.org/10.1007/s11095-006-0276-8
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1007/s11095-006-9186-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1015904974
    315 https://doi.org/10.1007/s11095-006-9186-z
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1016/0009-9236(95)90212-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017495934
    318 https://doi.org/10.1016/0009-9236(95)90212-0
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1023/a:1007524919865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006924689
    321 https://doi.org/10.1023/a:1007524919865
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1023/a:1008192010023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027150724
    324 https://doi.org/10.1023/a:1008192010023
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1023/a:1010971808006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022874918
    327 https://doi.org/10.1023/a:1010971808006
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1023/a:1011917508056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035872806
    330 https://doi.org/10.1023/a:1011917508056
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1023/a:1012141309951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045783205
    333 https://doi.org/10.1023/a:1012141309951
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1023/a:1012190620854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044600337
    336 https://doi.org/10.1023/a:1012190620854
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1023/a:1015831408425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006962937
    339 https://doi.org/10.1023/a:1015831408425
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1023/a:1016065114515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033257526
    342 https://doi.org/10.1023/a:1016065114515
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1023/a:1018896912889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052848399
    345 https://doi.org/10.1023/a:1018896912889
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1023/a:1018991917799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034706898
    348 https://doi.org/10.1023/a:1018991917799
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1038/14109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015839208
    351 https://doi.org/10.1038/14109
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1038/35036221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018866968
    354 https://doi.org/10.1038/35036221
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/bjc.1998.730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029434997
    357 https://doi.org/10.1038/bjc.1998.730
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1038/ncpneph0225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006086068
    360 https://doi.org/10.1038/ncpneph0225
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/nrd1658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042882951
    363 https://doi.org/10.1038/nrd1658
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1038/nrd2197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003326546
    366 https://doi.org/10.1038/nrd2197
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/nsmb1197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032101297
    369 https://doi.org/10.1038/nsmb1197
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1038/sj.bjc.6690558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014496843
    372 https://doi.org/10.1038/sj.bjc.6690558
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1038/sj.pcan.4500834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049875560
    375 https://doi.org/10.1038/sj.pcan.4500834
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1208/aapsj080477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025565916
    378 https://doi.org/10.1208/aapsj080477
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.2165/00003495-199040030-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001965472
    381 https://doi.org/10.2165/00003495-199040030-00001
    382 rdf:type schema:CreativeWork
    383 https://app.dimensions.ai/details/publication/pub.1074268023 schema:CreativeWork
    384 https://app.dimensions.ai/details/publication/pub.1074522744 schema:CreativeWork
    385 https://app.dimensions.ai/details/publication/pub.1074630345 schema:CreativeWork
    386 https://app.dimensions.ai/details/publication/pub.1075337220 schema:CreativeWork
    387 https://app.dimensions.ai/details/publication/pub.1075840489 schema:CreativeWork
    388 https://app.dimensions.ai/details/publication/pub.1076627936 schema:CreativeWork
    389 https://app.dimensions.ai/details/publication/pub.1076630230 schema:CreativeWork
    390 https://app.dimensions.ai/details/publication/pub.1076819854 schema:CreativeWork
    391 https://app.dimensions.ai/details/publication/pub.1076881130 schema:CreativeWork
    392 https://app.dimensions.ai/details/publication/pub.1077130917 schema:CreativeWork
    393 https://app.dimensions.ai/details/publication/pub.1077412179 schema:CreativeWork
    394 https://app.dimensions.ai/details/publication/pub.1078021184 schema:CreativeWork
    395 https://app.dimensions.ai/details/publication/pub.1078592105 schema:CreativeWork
    396 https://app.dimensions.ai/details/publication/pub.1078783408 schema:CreativeWork
    397 https://app.dimensions.ai/details/publication/pub.1079428827 schema:CreativeWork
    398 https://app.dimensions.ai/details/publication/pub.1079553452 schema:CreativeWork
    399 https://app.dimensions.ai/details/publication/pub.1079608913 schema:CreativeWork
    400 https://app.dimensions.ai/details/publication/pub.1079666990 schema:CreativeWork
    401 https://app.dimensions.ai/details/publication/pub.1079697043 schema:CreativeWork
    402 https://app.dimensions.ai/details/publication/pub.1079704924 schema:CreativeWork
    403 https://app.dimensions.ai/details/publication/pub.1080089109 schema:CreativeWork
    404 https://app.dimensions.ai/details/publication/pub.1081953728 schema:CreativeWork
    405 https://app.dimensions.ai/details/publication/pub.1081979007 schema:CreativeWork
    406 https://app.dimensions.ai/details/publication/pub.1081984625 schema:CreativeWork
    407 https://app.dimensions.ai/details/publication/pub.1082396501 schema:CreativeWork
    408 https://app.dimensions.ai/details/publication/pub.1082766977 schema:CreativeWork
    409 https://app.dimensions.ai/details/publication/pub.1082794727 schema:CreativeWork
    410 https://app.dimensions.ai/details/publication/pub.1082967664 schema:CreativeWork
    411 https://app.dimensions.ai/details/publication/pub.1083154725 schema:CreativeWork
    412 https://app.dimensions.ai/details/publication/pub.1083207457 schema:CreativeWork
    413 https://doi.org/10.1002/1520-6017(200008)89:8<1022::aid-jps6>3.0.co;2-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1026389798
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1002/1520-6017(200102)90:2<124::aid-jps3>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000556179
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1002/bdd.2510120607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032203640
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1002/bdd.357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033307842
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1002/bdd.457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007870621
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1002/bdd.476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045618218
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1002/j.1552-4604.1990.tb01868.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019123530
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1002/j.1875-9114.1991.tb04290.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007919955
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1002/j.1875-9114.1995.tb04336.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045699562
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1002/jps.10075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002227111
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1002/jps.10182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010252140
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1002/jps.10249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005671107
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1002/jps.1083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008349879
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1002/jps.1092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001934486
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1002/jps.2600830716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042881618
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1006/bbrc.2000.2441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032928267
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1016/0005-2736(83)90236-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031667820
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1016/0005-2760(78)90163-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041738802
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1016/0006-2952(92)90643-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1041239658
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1016/0009-9120(96)00001-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001435331
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1016/0021-9150(87)90106-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020907207
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1016/0092-8674(75)90182-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048994991
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1016/0092-8674(87)90510-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029811213
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1016/0140-6736(92)90707-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1044045864
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1016/j.addr.2003.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050307976
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1016/j.atherosclerosis.2006.06.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009471639
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1016/j.trim.2006.09.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036878120
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1016/s0006-2952(01)00708-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049880638
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1016/s0010-7824(79)80029-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049336272
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1016/s0014-5793(99)01731-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041944499
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1016/s0025-6196(12)64916-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009447090
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1016/s0140-6736(85)92679-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047119172
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1016/s0140-6736(86)90254-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012543292
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1016/s0140-6736(88)92538-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018723491
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1016/s0163-4453(94)95986-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030847662
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1016/s0168-3659(01)00278-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048061560
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1016/s0300-9084(85)80051-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002665430
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1016/s0962-8924(02)02282-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042945879
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1016/s1098-3597(05)80065-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040125991
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1016/s1473-3099(03)00801-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017529024
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1021/bi052535g schema:sameAs https://app.dimensions.ai/details/publication/pub.1055201545
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1021/js950472p schema:sameAs https://app.dimensions.ai/details/publication/pub.1042057431
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1021/js970407a schema:sameAs https://app.dimensions.ai/details/publication/pub.1044713147
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1021/js9704846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012161021
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1021/js980152g schema:sameAs https://app.dimensions.ai/details/publication/pub.1033164676
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1021/js980353k schema:sameAs https://app.dimensions.ai/details/publication/pub.1038241552
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1021/js990101z schema:sameAs https://app.dimensions.ai/details/publication/pub.1021800127
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1042/0264-6021:3490559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056714885
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1042/bj3490559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049320695
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1054/clnu.2000.0151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016433118
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1056/nejm198710013171404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016706912
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1056/nejmoa070635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038834066
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1073/pnas.75.7.3445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006001833
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1073/pnas.87.7.2598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043290552
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1073/pnas.89.10.4471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010161575
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1073/pnas.91.10.4431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025489043
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1073/pnas.91.21.9725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048730479
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.1074/jbc.m109959200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035319550
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.1074/jbc.m111764200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006992714
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.1074/jbc.m504678200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048931242
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.1080/00034983.1992.11812715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058265338
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.1080/07853890701214881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043781741
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.1081/ddc-54305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001434856
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.1086/302365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058609942
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.1093/ajhp/61.6.565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076819854
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.1093/clinids/14.supplement_1.s154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059472171
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.1093/jnci/djh216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007072140
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.1097/00005344-199912000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060206853
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.1097/00005768-199711000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060228312
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.1097/00007691-199107000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051578572
    552 rdf:type schema:CreativeWork
    553 https://doi.org/10.1097/00007691-199308000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017486264
    554 rdf:type schema:CreativeWork
    555 https://doi.org/10.1097/00007890-200103150-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032486553
    556 rdf:type schema:CreativeWork
    557 https://doi.org/10.1097/01.tp.0000074310.40484.94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018437036
    558 rdf:type schema:CreativeWork
    559 https://doi.org/10.1111/j.1365-2125.1989.tb03507.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004356471
    560 rdf:type schema:CreativeWork
    561 https://doi.org/10.1111/j.1365-2796.1990.tb00136.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010060485
    562 rdf:type schema:CreativeWork
    563 https://doi.org/10.1111/j.1399-5618.2004.00156.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045418093
    564 rdf:type schema:CreativeWork
    565 https://doi.org/10.1111/j.1432-1033.1978.tb12534.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049174723
    566 rdf:type schema:CreativeWork
    567 https://doi.org/10.1111/j.1432-1033.1995.tb20795.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030149412
    568 rdf:type schema:CreativeWork
    569 https://doi.org/10.1111/j.1468-1293.2005.00273.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005936317
    570 rdf:type schema:CreativeWork
    571 https://doi.org/10.1111/j.1749-6632.1965.tb34810.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017298485
    572 rdf:type schema:CreativeWork
    573 https://doi.org/10.1111/j.2042-7158.1986.tb03085.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050104802
    574 rdf:type schema:CreativeWork
    575 https://doi.org/10.1124/mol.52.3.445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083140502
    576 rdf:type schema:CreativeWork
    577 https://doi.org/10.1126/science.271.5248.518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552090
    578 rdf:type schema:CreativeWork
    579 https://doi.org/10.1126/science.3513311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062618548
    580 rdf:type schema:CreativeWork
    581 https://doi.org/10.1128/aac.37.2.246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025875716
    582 rdf:type schema:CreativeWork
    583 https://doi.org/10.1128/aac.38.2.223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030153376
    584 rdf:type schema:CreativeWork
    585 https://doi.org/10.1128/aac.38.9.2224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000494465
    586 rdf:type schema:CreativeWork
    587 https://doi.org/10.1128/aac.41.9.1871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083149466
    588 rdf:type schema:CreativeWork
    589 https://doi.org/10.1128/aac.42.8.1878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083299280
    590 rdf:type schema:CreativeWork
    591 https://doi.org/10.1128/aac.45.4.1184-1191.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052742368
    592 rdf:type schema:CreativeWork
    593 https://doi.org/10.1128/aac.48.9.3233-3240.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000019595
    594 rdf:type schema:CreativeWork
    595 https://doi.org/10.1146/annurev.biochem.74.082803.133354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013414280
    596 rdf:type schema:CreativeWork
    597 https://doi.org/10.1146/annurev.pa.23.040183.001511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040921276
    598 rdf:type schema:CreativeWork
    599 https://doi.org/10.1152/ajprenal.2001.281.2.f337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074850598
    600 rdf:type schema:CreativeWork
    601 https://doi.org/10.1158/0008-5472.can-03-0675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013980246
    602 rdf:type schema:CreativeWork
    603 https://doi.org/10.1159/000184795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029596778
    604 rdf:type schema:CreativeWork
    605 https://doi.org/10.1161/01.atv.0000154144.73236.f4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039997135
    606 rdf:type schema:CreativeWork
    607 https://doi.org/10.1161/01.hyp.19.1_suppl.i110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063338783
    608 rdf:type schema:CreativeWork
    609 https://doi.org/10.1161/01.res.35.5.713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023729868
    610 rdf:type schema:CreativeWork
    611 https://doi.org/10.1161/atvbaha.107.142570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016402146
    612 rdf:type schema:CreativeWork
    613 https://doi.org/10.1161/circulationaha.105.593855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019634079
    614 rdf:type schema:CreativeWork
    615 https://doi.org/10.1172/jci107989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019714325
    616 rdf:type schema:CreativeWork
    617 https://doi.org/10.1172/jci116663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032092024
    618 rdf:type schema:CreativeWork
    619 https://doi.org/10.1172/jci118149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035862876
    620 rdf:type schema:CreativeWork
    621 https://doi.org/10.1172/jci118176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004119916
    622 rdf:type schema:CreativeWork
    623 https://doi.org/10.1172/jci13992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416141
    624 rdf:type schema:CreativeWork
    625 https://doi.org/10.1172/jci30163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016261835
    626 rdf:type schema:CreativeWork
    627 https://doi.org/10.1176/appi.ajp.158.6.949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063493920
    628 rdf:type schema:CreativeWork
    629 https://doi.org/10.1177/00912709922008498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001506123
    630 rdf:type schema:CreativeWork
    631 https://doi.org/10.1194/jlr.d500033-jlr200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013013671
    632 rdf:type schema:CreativeWork
    633 https://doi.org/10.1210/endo-105-3-605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064254412
    634 rdf:type schema:CreativeWork
    635 https://doi.org/10.1210/jc.2007-0275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064289882
    636 rdf:type schema:CreativeWork
    637 https://doi.org/10.1210/jc.74.5.1045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064296270
    638 rdf:type schema:CreativeWork
    639 https://doi.org/10.1210/jc.76.6.1423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064296888
    640 rdf:type schema:CreativeWork
    641 https://doi.org/10.1210/jcem.74.5.1373735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064317511
    642 rdf:type schema:CreativeWork
    643 https://doi.org/10.1211/0022357021779104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017585671
    644 rdf:type schema:CreativeWork
    645 https://doi.org/10.1248/bpb.24.579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035996421
    646 rdf:type schema:CreativeWork
    647 https://doi.org/10.1248/bpb.24.683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052785349
    648 rdf:type schema:CreativeWork
    649 https://doi.org/10.1359/jbmr.041102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032192741
    650 rdf:type schema:CreativeWork
    651 https://doi.org/10.1515/cclm.1993.31.10.633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053629124
    652 rdf:type schema:CreativeWork
    653 https://doi.org/10.21236/ada408103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075105015
    654 rdf:type schema:CreativeWork
    655 https://doi.org/10.3949/ccjm.72.12.1113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071759836
    656 rdf:type schema:CreativeWork
    657 https://doi.org/10.4088/jcp.1106e16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072205124
    658 rdf:type schema:CreativeWork
    659 https://doi.org/10.4088/jcp.v60n0602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072207418
    660 rdf:type schema:CreativeWork
    661 https://doi.org/10.4088/jcp.v66n0503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072209135
    662 rdf:type schema:CreativeWork
    663 https://doi.org/10.4088/jcp.v67n0704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072209534
    664 rdf:type schema:CreativeWork
    665 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
    666 schema:name Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada V6T 1Z3. kwasan@interchange.ubc.ca
    667 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...