Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-05

AUTHORS

Robert A Casero, Laurence J Marton

ABSTRACT

The polyamines spermidine and spermine and their diamine precursor putrescine are naturally occurring, polycationic alkylamines that are essential for eukaryotic cell growth. The requirement for and the metabolism of polyamines are frequently dysregulated in cancer and other hyperproliferative diseases, thus making polyamine function and metabolism attractive targets for therapeutic intervention. Recent advances in our understanding of polyamine function, metabolic regulation, and differences between normal cells and tumour cells with respect to polyamine biology, have reinforced the interest in this target-rich pathway for drug development. More... »

PAGES

373-390

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrd2243

    DOI

    http://dx.doi.org/10.1038/nrd2243

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024966872

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17464296


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    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrd2243'

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