More than one reason to rethink the use of peptides in vaccine design View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-05

AUTHORS

Anthony W. Purcell, James McCluskey, Jamie Rossjohn

ABSTRACT

The use of peptides as therapeutics is experiencing renewed enthusiasm owing to advances in delivery, stability and design. Moreover, there is a growing emphasis on the use of peptides in vaccine design as insights into tissue-specific processing of the immunogenic epitopes of proteins and the discovery of unusually long cytotoxic T-lymphocyte epitopes broaden the range of targets and give clues to enhancing peptide immunogenicity. Peptides can also be synthesized with known post-translational modifications and/or deliberately introduced protease-resistant peptide bonds to regulate their processing independent of tissue-specific proteolysis and to stabilize these compounds in vivo. We discuss the potential of peptide-based vaccines for the treatment of chronic viral diseases and cancer, and review recent developments in the field of peptide-based vaccines. More... »

PAGES

404-414

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrd2224

    DOI

    http://dx.doi.org/10.1038/nrd2224

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013421300

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17473845


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