Drugs for bad bugs: confronting the challenges of antibacterial discovery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-01

AUTHORS

David J Payne, Michael N Gwynn, David J Holmes, David L Pompliano

ABSTRACT

The sequencing of the first complete bacterial genome in 1995 heralded a new era of hope for antibacterial drug discoverers, who now had the tools to search entire genomes for new antibacterial targets. Several companies, including GlaxoSmithKline, moved back into the antibacterials area and embraced a genomics-derived, target-based approach to screen for new classes of drugs with novel modes of action. Here, we share our experience of evaluating more than 300 genes and 70 high-throughput screening campaigns over a period of 7 years, and look at what we learned and how that has influenced GlaxoSmithKline's antibacterials strategy going forward. More... »

PAGES

29-40

References to SciGraph publications

  • 2000-07. Microbiology: A triclosan-resistant bacterial enzyme in NATURE
  • 2002-05. An array of target-specific screening strains for antibacterial discovery in NATURE BIOTECHNOLOGY
  • 2004-10. Antibiotics at the crossroads in NATURE
  • 2004. Genomic Approaches to Antibacterial Discovery in GENOMICS, PROTEOMICS, AND CLINICAL BACTERIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrd2201

    DOI

    http://dx.doi.org/10.1038/nrd2201

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005793977

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17159923


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