A robustness-based approach to systems-oriented drug design View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-03

AUTHORS

Hiroaki Kitano

ABSTRACT

Many potential drugs that specifically target a particular protein considered to underlie a given disease have been found to be less effective than hoped, or to cause significant side effects. The intrinsic robustness of living systems against various perturbations is a key factor that prevents such compounds from being successful. By studying complex network systems and reformulating control and communication theories that are well established in engineering, a theoretical foundation for a systems-oriented approach to more effectively control the robustness of living systems, particularly at the cellular level, could be developed. Here, I use examples that are based on existing drugs to illustrate the concept of robustness, and then discuss how a greater consideration of the importance of robustness could influence the design of new drugs that will be intended to control complex systems. More... »

PAGES

202-210

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrd2195

DOI

http://dx.doi.org/10.1038/nrd2195

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026313123

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17318209


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