Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-04

AUTHORS

Leslie M Shaw, Magdalena Korecka, Christopher M Clark, Virginia M-Y Lee, John Q Trojanowski

ABSTRACT

Rapid progress towards understanding the molecular underpinnings of neurodegenerative disorders such as Alzheimer's disease is revolutionizing drug discovery for these conditions. Furthermore, the development of models for these disorders is accelerating efforts to translate insights related to neurodegenerative mechanisms into disease-modifying therapies. However, there is an urgent need for biomarkers to diagnose neurodegenerative disorders early in their course, when therapy is likely to be most effective, and to monitor responses of patients to new therapies. As research related to this need is currently most advanced for Alzheimer's disease, this Review focuses on progress in the development and validation of biomarkers to improve the diagnosis and treatment of Alzheimer's disease and related disorders. More... »

PAGES

295-303

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrd2176

DOI

http://dx.doi.org/10.1038/nrd2176

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019893204

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17347655


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