Epigenetic therapy of cancer: past, present and future View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-01

AUTHORS

Christine B. Yoo, Peter A. Jones

ABSTRACT

The initiation and progression of cancer is controlled by both genetic and epigenetic events. Unlike genetic alterations, which are almost impossible to reverse, epigenetic aberrations are potentially reversible, allowing the malignant cell population to revert to a more normal state. With the advent of numerous drugs that target specific enzymes involved in the epigenetic regulation of gene expression, the utilization of epigenetic targets is emerging as an effective and valuable approach to chemotherapy as well as chemoprevention of cancer. More... »

PAGES

37-50

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  • Journal

    TITLE

    Nature Reviews Drug Discovery

    ISSUE

    1

    VOLUME

    5

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrd1930

    DOI

    http://dx.doi.org/10.1038/nrd1930

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021896263

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16485345


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