The dawning era of polymer therapeutics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-05

AUTHORS

Ruth Duncan

ABSTRACT

As we enter the twenty-first century, research at the interface of polymer chemistry and the biomedical sciences has given rise to the first nano-sized (5-100 nm) polymer-based pharmaceuticals, the 'polymer therapeutics'. Polymer therapeutics include rationally designed macromolecular drugs, polymer-drug and polymer-protein conjugates, polymeric micelles containing covalently bound drug, and polyplexes for DNA delivery. The successful clinical application of polymer-protein conjugates, and promising clinical results arising from trials with polymer-anticancer-drug conjugates, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age. More... »

PAGES

347-360

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  • Journal

    TITLE

    Nature Reviews Drug Discovery

    ISSUE

    5

    VOLUME

    2

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrd1088

    DOI

    http://dx.doi.org/10.1038/nrd1088

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010845241

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12750738


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