MicroRNA therapeutics: towards a new era for the management of cancer and other diseases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-03

AUTHORS

Rajesha Rupaimoole, Frank J. Slack

ABSTRACT

In just over two decades since the discovery of the first microRNA (miRNA), the field of miRNA biology has expanded considerably. Insights into the roles of miRNAs in development and disease, particularly in cancer, have made miRNAs attractive tools and targets for novel therapeutic approaches. Functional studies have confirmed that miRNA dysregulation is causal in many cases of cancer, with miRNAs acting as tumour suppressors or oncogenes (oncomiRs), and miRNA mimics and molecules targeted at miRNAs (antimiRs) have shown promise in preclinical development. Several miRNA-targeted therapeutics have reached clinical development, including a mimic of the tumour suppressor miRNA miR-34, which reached phase I clinical trials for treating cancer, and antimiRs targeted at miR-122, which reached phase II trials for treating hepatitis. In this article, we describe recent advances in our understanding of miRNAs in cancer and in other diseases and provide an overview of current miRNA therapeutics in the clinic. We also discuss the challenge of identifying the most efficacious therapeutic candidates and provide a perspective on achieving safe and targeted delivery of miRNA therapeutics. More... »

PAGES

203-222

References to SciGraph publications

  • 2016-06. Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas in NATURE GENETICS
  • 2011-12. Non-coding RNAs in human disease in NATURE REVIEWS GENETICS
  • 2007-06. Hypoxia in cancer: significance and impact on clinical outcome in CANCER AND METASTASIS REVIEWS
  • 2012-02. Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320 in NATURE CELL BIOLOGY
  • 2010-09. OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma in NATURE
  • 2007-10-11. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer in NATURE
  • 2011-10. Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides in NATURE
  • 2005-12. Silencing of microRNAs in vivo with ‘antagomirs’ in NATURE
  • 2006-09. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster in NATURE GENETICS
  • 2000-02. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans in NATURE
  • 2013-12. c-Myc modulates microRNA processing via the transcriptional regulation of Drosha in SCIENTIFIC REPORTS
  • 2014-12. Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER in NATURE COMMUNICATIONS
  • 2015-02. MicroRNA silencing for cancer therapy targeted to the tumour microenvironment in NATURE
  • 2008-12-18. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts in NATURE
  • 2012-11. MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles in NATURE REVIEWS DRUG DISCOVERY
  • 2014-12. Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression in NATURE COMMUNICATIONS
  • 2009-07-05. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity in NATURE
  • 2015-02. miR-CLIP capture of a miRNA targetome uncovers a lincRNA H19–miR-106a interaction in NATURE CHEMICAL BIOLOGY
  • 2010-04. Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model in NATURE BIOTECHNOLOGY
  • 2015-06. The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes in NATURE MEDICINE
  • 2014-12. Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours in NATURE COMMUNICATIONS
  • 2013-12. The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease in CELL DEATH & DIFFERENTIATION
  • 2013-12. MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation in SCIENTIFIC REPORTS
  • 2011-03. miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity in CELL DEATH & DIFFERENTIATION
  • 2012-01. The microRNA-processing enzymes: Drosha and Dicer can predict prognosis of nasopharyngeal carcinoma in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2011-08. Major regulators of microRNAs biogenesis Dicer and Drosha are down-regulated in endometrial cancer in TUMOR BIOLOGY
  • 2010-04-15. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles in NATURE
  • 2008-05. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 in NATURE CELL BIOLOGY
  • 2013-12. Tumour angiogenesis regulation by the miR-200 family in NATURE COMMUNICATIONS
  • 2014-01. Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia in LEUKEMIA
  • 2012-04. The blockade of immune checkpoints in cancer immunotherapy in NATURE REVIEWS CANCER
  • 2011-10. Germline deletion of the miR-17∼92 cluster causes skeletal and growth defects in humans in NATURE GENETICS
  • 2013-02. Regulatory networks defining EMT during cancer initiation and progression in NATURE REVIEWS CANCER
  • 2010-10. TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs in NATURE
  • 2011-02. The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44 in NATURE MEDICINE
  • 2015-06. MicroRNA biogenesis pathways in cancer in NATURE REVIEWS CANCER
  • 2014-02. Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer in ONCOGENE
  • 2005-06. c-Myc-regulated microRNAs modulate E2F1 expression in NATURE
  • 2015-06. MicroRNA regulons in tumor microenvironment in ONCOGENE
  • 2015-01. Role of miR-15/16 in CLL in CELL DEATH & DIFFERENTIATION
  • 2002-12. Inflammation and cancer in NATURE
  • 2013-05. EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2 in NATURE
  • 2012-09. MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways in ONCOGENE
  • 2013-05. MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1 in CLINICAL AND EXPERIMENTAL MEDICINE
  • 2014-08. Regulation of microRNA biogenesis in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2008-04. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer in ONCOGENE
  • 2011-06-08. MicroRNAs 103 and 107 regulate insulin sensitivity in NATURE
  • 2016-02. microRNA-10b is a prognostic biomarker for melanoma in MODERN PATHOLOGY
  • 2012-12. Functional screening identifies miRNAs inducing cardiac regeneration in NATURE
  • 2016-08. Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression in ONCOGENE
  • 2000-11. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA in NATURE
  • 2014-08. Therapeutic targeting of microRNAs: current status and future challenges in NATURE REVIEWS DRUG DISCOVERY
  • 2008-04-17. LNA-mediated microRNA silencing in non-human primates in NATURE
  • 2012-01. MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1 in ONCOGENE
  • 2010-06. MicroRNA-21 in Cardiovascular Disease in JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
  • 2016-12. Essential role of miRNAs in orchestrating the biology of the tumor microenvironment in MOLECULAR CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrd.2016.246

    DOI

    http://dx.doi.org/10.1038/nrd.2016.246

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1083845449

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28209991


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Clinical Trials as Topic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Management", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "MicroRNAs", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Institute for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center Cancer Center, Harvard Medical School, Boston, Massachusetts 02215, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rupaimoole", 
            "givenName": "Rajesha", 
            "id": "sg:person.011034742527.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011034742527.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Institute for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center Cancer Center, Harvard Medical School, Boston, Massachusetts 02215, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Slack", 
            "givenName": "Frank J.", 
            "id": "sg:person.01172402025.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172402025.03"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-08-0021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000376245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd3864", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000522206", 
              "https://doi.org/10.1038/nrd3864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/mtna.2014.47", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000696990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1842409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000762433"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2013.08.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002245965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0901282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002363689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-10-3568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002661412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-12-0206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002738808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci73531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002954873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms5802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003663410", 
              "https://doi.org/10.1038/ncomms5802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.02.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003684444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1640608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004123559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.111.244442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004295163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.111.244442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004295163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.111.030932", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004700361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004880322", 
              "https://doi.org/10.1038/nature09459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004880322", 
              "https://doi.org/10.1038/nature09459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.10.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006059863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-4074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006514003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci38864", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006895222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci38864", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006895222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.27443", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007141847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.27443", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007141847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.2005.00015.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007310658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2012.636", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007355288", 
              "https://doi.org/10.1038/onc.2012.636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2012.636", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007355288", 
              "https://doi.org/10.1038/onc.2012.636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007963177", 
              "https://doi.org/10.1038/nature08195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007963177", 
              "https://doi.org/10.1038/nature08195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db11-1086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008363834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/mt.2014.79", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009500801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkm1113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009727938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.01.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010338150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2007.03.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010739271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0804746105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010822801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010854443", 
              "https://doi.org/10.1038/nrg3074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7601790", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011000169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db09-1736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011195928"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.04.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011455689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01222-08", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011818148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m707224200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012014539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0601463103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012334818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci63455", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012337417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3932", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012737365", 
              "https://doi.org/10.1038/nrc3932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3838", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014084316", 
              "https://doi.org/10.1038/nrm3838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014546686", 
              "https://doi.org/10.1038/nature06174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.03631-14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014709518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.1713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015713857", 
              "https://doi.org/10.1038/nchembio.1713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13277-011-0179-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016287237", 
              "https://doi.org/10.1007/s13277-011-0179-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2013.125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016946790", 
              "https://doi.org/10.1038/cdd.2013.125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djv303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017434170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djv303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017434170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1201516109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017684729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-13-0159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017778945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.194969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017779820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1261/rna.1034808", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017884514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/imr.12050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018294988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2010.119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018667507", 
              "https://doi.org/10.1038/cdd.2010.119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-1083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018927559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019252906", 
              "https://doi.org/10.1038/nature10112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019336134", 
              "https://doi.org/10.1038/nature01322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019336134", 
              "https://doi.org/10.1038/nature01322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11739", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019521277", 
              "https://doi.org/10.1038/nature11739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-15-0893", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020615054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2013.246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020966033", 
              "https://doi.org/10.1038/leu.2013.246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2013.246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020966033", 
              "https://doi.org/10.1038/leu.2013.246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-11-1144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021573821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2011.07.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021944437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/emmm.201100209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022068361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2007.05.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022322235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cellsig.2014.12.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022495924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/mt.2011.48", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022661211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/humu.20750", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022993449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2009.02.097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023089871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0703942104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023155459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2012.12.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023188068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e11-02-0103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023253161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1113329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023422868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yexcr.2012.02.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023835661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd4359", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023956879", 
              "https://doi.org/10.1038/nrd4359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2007.05.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024011682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024444585", 
              "https://doi.org/10.1038/nature09284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024444585", 
              "https://doi.org/10.1038/nature09284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1618", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024956742", 
              "https://doi.org/10.1038/nbt.1618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.233585.113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025118252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.233585.113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025118252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-11-0152", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025758379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms6203", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025818132", 
              "https://doi.org/10.1038/ncomms6203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1102281108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026108806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-011-1058-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026363766", 
              "https://doi.org/10.1007/s00432-011-1058-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-011-1058-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026363766", 
              "https://doi.org/10.1007/s00432-011-1058-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1582-4934.2008.00556.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026654179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.297.17.1901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026824938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.addr.2005.09.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026857203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1209026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026864726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkv1258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026886886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/hco.0000000000000280", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027066036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/hco.0000000000000280", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027066036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-15-0854", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027069464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2010.08.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027223734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2013.11.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027338340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1855", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027542691", 
              "https://doi.org/10.1038/ng1855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1855", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027542691", 
              "https://doi.org/10.1038/ng1855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01395-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027701800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0902636106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028163409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.03.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028293119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2011.571", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028508342", 
              "https://doi.org/10.1038/onc.2011.571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-2516", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028573658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028690550", 
              "https://doi.org/10.1038/nrc3447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028723946", 
              "https://doi.org/10.1038/nature07511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028846082", 
              "https://doi.org/10.1038/nature12080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029059457", 
              "https://doi.org/10.1038/nature10486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2009.10.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029310321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m800731200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029400347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci63539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030233492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci63539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030233492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2011.263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030237115", 
              "https://doi.org/10.1038/onc.2011.263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-0530", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030443527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06783", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031121151", 
              "https://doi.org/10.1038/nature06783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkt1248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031236821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(04)00045-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031254572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jbm.820050305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031910318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djv108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031913448"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3862", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032144824", 
              "https://doi.org/10.1038/nm.3862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/embor.2008.74", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032429234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.02.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033132999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0800121105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034225351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10238-012-0186-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034548550", 
              "https://doi.org/10.1007/s10238-012-0186-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2010.09.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034759885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db10-1557", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035227761"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.05.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035246723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2008.03.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035553445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08956", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035909146", 
              "https://doi.org/10.1038/nature08956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08956", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035909146", 
              "https://doi.org/10.1038/nature08956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.4348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037296109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2010.07.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037315878"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.236950", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037541954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0071637", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039290073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-10-4645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039600044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13905", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039740519", 
              "https://doi.org/10.1038/nature13905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2006.05.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039888012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2459/jcm.0000000000000246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040540990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2459/jcm.0000000000000246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040540990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2014.87", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040889995", 
              "https://doi.org/10.1038/cdd.2014.87"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja505986a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040895801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-10-0655", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041015690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35040556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041493395", 
              "https://doi.org/10.1038/35040556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35040556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041493395", 
              "https://doi.org/10.1038/35040556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2014.254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041745187", 
              "https://doi.org/10.1038/onc.2014.254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.c800074200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041926183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5732/cjc.011.10186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042024650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep01942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042341369", 
              "https://doi.org/10.1038/srep01942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/emmm.201404046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042497801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12943-016-0525-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042826609", 
              "https://doi.org/10.1186/s12943-016-0525-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2011.01.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043029093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2015.149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043394938", 
              "https://doi.org/10.1038/modpathol.2015.149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tcb.2008.07.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044009500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ppo.0b013e318258b75b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044063478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ppo.0b013e318258b75b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044063478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2010.08.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044623775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0907904107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045318191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/emmm.201100899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045530046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03677", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045691844", 
              "https://doi.org/10.1038/nature03677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03677", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045691844", 
              "https://doi.org/10.1038/nature03677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045870087", 
              "https://doi.org/10.1038/nature04303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045870087", 
              "https://doi.org/10.1038/nature04303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045870087", 
              "https://doi.org/10.1038/nature04303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.05005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046247280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1102903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046348995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1317242111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047118954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1722", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047429448", 
              "https://doi.org/10.1038/ncb1722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgn187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047490751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2015.492", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047665213", 
              "https://doi.org/10.1038/onc.2015.492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35002607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047689840", 
              "https://doi.org/10.1038/35002607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35002607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047689840", 
              "https://doi.org/10.1038/35002607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047946992", 
              "https://doi.org/10.1038/nrc3239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1261/rna.1155108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048224171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdv090.2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048231165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep02038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048494691", 
              "https://doi.org/10.1038/srep02038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0803785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049319966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2009.11.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049400026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10555-007-9055-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049789382", 
              "https://doi.org/10.1007/s10555-007-9055-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10555-007-9055-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049789382", 
              "https://doi.org/10.1007/s10555-007-9055-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12265-010-9169-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049807798", 
              "https://doi.org/10.1007/s12265-010-9169-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12265-010-9169-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049807798", 
              "https://doi.org/10.1007/s12265-010-9169-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms3427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049966583", 
              "https://doi.org/10.1038/ncomms3427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.10.054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050608753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/emmm.201303604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050816814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fgene.2012.00120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050939524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/08830180903093796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050971290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-12-2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051005493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-12-2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051005493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(93)90529-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051619915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2008.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051659714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051843869", 
              "https://doi.org/10.1038/nm.2284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2011050485", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051897121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2011050485", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051897121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms6202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052126699", 
              "https://doi.org/10.1038/ncomms6202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms6202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052126699", 
              "https://doi.org/10.1038/ncomms6202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2796.2009.02191.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052253625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2796.2009.02191.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052253625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3003205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052341351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1101795108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052444338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2006.01.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052534178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052685738", 
              "https://doi.org/10.1038/ng.915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210856", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052742288", 
              "https://doi.org/10.1038/sj.onc.1210856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbadis.2009.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053232130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3564", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053389438", 
              "https://doi.org/10.1038/ng.3564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.04220-14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053531138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2396", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053604598", 
              "https://doi.org/10.1038/ncb2396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc990072j", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055156465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc990072j", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055156465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15384101.2014.1003008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058401749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1174334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062460178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1174334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062460178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1189862", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062461810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-15-0888", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063215812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-15-0888", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063215812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.targ-15-c43", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063229575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1538-7445.am2015-397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063262782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1538-7445.am2015-3976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063262789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci33494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063417065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.2013.1935", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071513132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.2013.1935", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071513132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/19420862.2014.985952", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072288697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.6.13.4436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072299006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074754944", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-03", 
        "datePublishedReg": "2017-03-01", 
        "description": "In just over two decades since the discovery of the first microRNA (miRNA), the field of miRNA biology has expanded considerably. Insights into the roles of miRNAs in development and disease, particularly in cancer, have made miRNAs attractive tools and targets for novel therapeutic approaches. Functional studies have confirmed that miRNA dysregulation is causal in many cases of cancer, with miRNAs acting as tumour suppressors or oncogenes (oncomiRs), and miRNA mimics and molecules targeted at miRNAs (antimiRs) have shown promise in preclinical development. Several miRNA-targeted therapeutics have reached clinical development, including a mimic of the tumour suppressor miRNA miR-34, which reached phase I clinical trials for treating cancer, and antimiRs targeted at miR-122, which reached phase II trials for treating hepatitis. In this article, we describe recent advances in our understanding of miRNAs in cancer and in other diseases and provide an overview of current miRNA therapeutics in the clinic. We also discuss the challenge of identifying the most efficacious therapeutic candidates and provide a perspective on achieving safe and targeted delivery of miRNA therapeutics.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nrd.2016.246", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2481339", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1327423", 
            "issn": [
              "1474-1776", 
              "1474-1784"
            ], 
            "name": "Nature Reviews Drug Discovery", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "16"
          }
        ], 
        "name": "MicroRNA therapeutics: towards a new era for the management of cancer and other diseases", 
        "pagination": "203-222", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "87045b0973c1f04245b99823260e68ace078f2e8cc83e5de40799b87de52517e"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28209991"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101124171"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrd.2016.246"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1083845449"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrd.2016.246", 
          "https://app.dimensions.ai/details/publication/pub.1083845449"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:04", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000427.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/nrd/journal/v16/n3/full/nrd.2016.246.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrd.2016.246'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrd.2016.246'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrd.2016.246'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrd.2016.246'


     

    This table displays all metadata directly associated to this object as RDF triples.

    740 TRIPLES      21 PREDICATES      229 URIs      28 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrd.2016.246 schema:about N1110a7b92eaf43cf93e5e92ffc376677
    2 N19a6db51a4c545418b752ea23d61c6de
    3 N2646691946574652a048bdb7e18cc2f0
    4 N299986c261ca4ba493909c2e22a29418
    5 N5ae25eb697e747608bc44dcb0ce27f7e
    6 N6889af1d608343c8b02f688da615e4db
    7 Nd1618f247d8b4d1ba82e6d4125752080
    8 anzsrc-for:11
    9 anzsrc-for:1112
    10 schema:author Na71373c87a6b446580e5a8e9e43e23f7
    11 schema:citation sg:pub.10.1007/s00432-011-1058-1
    12 sg:pub.10.1007/s10238-012-0186-5
    13 sg:pub.10.1007/s10555-007-9055-1
    14 sg:pub.10.1007/s12265-010-9169-7
    15 sg:pub.10.1007/s13277-011-0179-0
    16 sg:pub.10.1038/35002607
    17 sg:pub.10.1038/35040556
    18 sg:pub.10.1038/cdd.2010.119
    19 sg:pub.10.1038/cdd.2013.125
    20 sg:pub.10.1038/cdd.2014.87
    21 sg:pub.10.1038/leu.2013.246
    22 sg:pub.10.1038/modpathol.2015.149
    23 sg:pub.10.1038/nature01322
    24 sg:pub.10.1038/nature03677
    25 sg:pub.10.1038/nature04303
    26 sg:pub.10.1038/nature06174
    27 sg:pub.10.1038/nature06783
    28 sg:pub.10.1038/nature07511
    29 sg:pub.10.1038/nature08195
    30 sg:pub.10.1038/nature08956
    31 sg:pub.10.1038/nature09284
    32 sg:pub.10.1038/nature09459
    33 sg:pub.10.1038/nature10112
    34 sg:pub.10.1038/nature10486
    35 sg:pub.10.1038/nature11739
    36 sg:pub.10.1038/nature12080
    37 sg:pub.10.1038/nature13905
    38 sg:pub.10.1038/nbt.1618
    39 sg:pub.10.1038/ncb1722
    40 sg:pub.10.1038/ncb2396
    41 sg:pub.10.1038/nchembio.1713
    42 sg:pub.10.1038/ncomms3427
    43 sg:pub.10.1038/ncomms5802
    44 sg:pub.10.1038/ncomms6202
    45 sg:pub.10.1038/ncomms6203
    46 sg:pub.10.1038/ng.3564
    47 sg:pub.10.1038/ng.915
    48 sg:pub.10.1038/ng1855
    49 sg:pub.10.1038/nm.2284
    50 sg:pub.10.1038/nm.3862
    51 sg:pub.10.1038/nrc3239
    52 sg:pub.10.1038/nrc3447
    53 sg:pub.10.1038/nrc3932
    54 sg:pub.10.1038/nrd3864
    55 sg:pub.10.1038/nrd4359
    56 sg:pub.10.1038/nrg3074
    57 sg:pub.10.1038/nrm3838
    58 sg:pub.10.1038/onc.2011.263
    59 sg:pub.10.1038/onc.2011.571
    60 sg:pub.10.1038/onc.2012.636
    61 sg:pub.10.1038/onc.2014.254
    62 sg:pub.10.1038/onc.2015.492
    63 sg:pub.10.1038/sj.onc.1210856
    64 sg:pub.10.1038/srep01942
    65 sg:pub.10.1038/srep02038
    66 sg:pub.10.1186/s12943-016-0525-3
    67 https://app.dimensions.ai/details/publication/pub.1074754944
    68 https://doi.org/10.1001/jama.297.17.1901
    69 https://doi.org/10.1002/art.27443
    70 https://doi.org/10.1002/emmm.201100209
    71 https://doi.org/10.1002/humu.20750
    72 https://doi.org/10.1002/jbm.820050305
    73 https://doi.org/10.1002/path.4348
    74 https://doi.org/10.1016/0092-8674(93)90529-y
    75 https://doi.org/10.1016/j.addr.2005.09.019
    76 https://doi.org/10.1016/j.bbadis.2009.02.013
    77 https://doi.org/10.1016/j.bbrc.2009.02.097
    78 https://doi.org/10.1016/j.ccr.2007.03.012
    79 https://doi.org/10.1016/j.ccr.2009.10.014
    80 https://doi.org/10.1016/j.ccr.2009.11.019
    81 https://doi.org/10.1016/j.ccr.2010.08.013
    82 https://doi.org/10.1016/j.ccr.2010.09.007
    83 https://doi.org/10.1016/j.ccr.2012.12.020
    84 https://doi.org/10.1016/j.cell.2005.01.014
    85 https://doi.org/10.1016/j.cell.2007.10.054
    86 https://doi.org/10.1016/j.cell.2008.02.020
    87 https://doi.org/10.1016/j.cell.2009.04.021
    88 https://doi.org/10.1016/j.cell.2009.10.014
    89 https://doi.org/10.1016/j.cell.2010.05.017
    90 https://doi.org/10.1016/j.cell.2012.03.029
    91 https://doi.org/10.1016/j.cell.2015.02.025
    92 https://doi.org/10.1016/j.cellsig.2014.12.003
    93 https://doi.org/10.1016/j.cmet.2006.01.005
    94 https://doi.org/10.1016/j.ejca.2010.08.007
    95 https://doi.org/10.1016/j.jconrel.2006.05.023
    96 https://doi.org/10.1016/j.jconrel.2008.04.002
    97 https://doi.org/10.1016/j.jconrel.2011.07.035
    98 https://doi.org/10.1016/j.jconrel.2013.08.005
    99 https://doi.org/10.1016/j.jmb.2008.03.015
    100 https://doi.org/10.1016/j.molcel.2007.05.010
    101 https://doi.org/10.1016/j.molcel.2007.05.017
    102 https://doi.org/10.1016/j.molcel.2010.07.023
    103 https://doi.org/10.1016/j.molcel.2011.01.020
    104 https://doi.org/10.1016/j.stem.2013.11.001
    105 https://doi.org/10.1016/j.tcb.2008.07.007
    106 https://doi.org/10.1016/j.yexcr.2012.02.010
    107 https://doi.org/10.1016/s0092-8674(04)00045-5
    108 https://doi.org/10.1021/bc990072j
    109 https://doi.org/10.1021/ja505986a
    110 https://doi.org/10.1038/embor.2008.74
    111 https://doi.org/10.1038/mt.2011.48
    112 https://doi.org/10.1038/mt.2014.79
    113 https://doi.org/10.1038/mtna.2014.47
    114 https://doi.org/10.1038/sj.emboj.7601790
    115 https://doi.org/10.1056/nejmoa0803785
    116 https://doi.org/10.1056/nejmoa0901282
    117 https://doi.org/10.1056/nejmoa1102903
    118 https://doi.org/10.1056/nejmoa1209026
    119 https://doi.org/10.1073/pnas.0601463103
    120 https://doi.org/10.1073/pnas.0703942104
    121 https://doi.org/10.1073/pnas.0800121105
    122 https://doi.org/10.1073/pnas.0804746105
    123 https://doi.org/10.1073/pnas.0902636106
    124 https://doi.org/10.1073/pnas.0907904107
    125 https://doi.org/10.1073/pnas.1101795108
    126 https://doi.org/10.1073/pnas.1102281108
    127 https://doi.org/10.1073/pnas.1201516109
    128 https://doi.org/10.1073/pnas.1317242111
    129 https://doi.org/10.1074/jbc.c800074200
    130 https://doi.org/10.1074/jbc.m110.194969
    131 https://doi.org/10.1074/jbc.m111.236950
    132 https://doi.org/10.1074/jbc.m707224200
    133 https://doi.org/10.1074/jbc.m800731200
    134 https://doi.org/10.1080/08830180903093796
    135 https://doi.org/10.1080/15384101.2014.1003008
    136 https://doi.org/10.1091/mbc.e11-02-0103
    137 https://doi.org/10.1093/annonc/mdv090.2
    138 https://doi.org/10.1093/carcin/bgn187
    139 https://doi.org/10.1093/jnci/djv108
    140 https://doi.org/10.1093/jnci/djv303
    141 https://doi.org/10.1093/nar/gkm1113
    142 https://doi.org/10.1093/nar/gkt1248
    143 https://doi.org/10.1093/nar/gkv1258
    144 https://doi.org/10.1097/hco.0000000000000280
    145 https://doi.org/10.1097/ppo.0b013e318258b75b
    146 https://doi.org/10.1101/gad.1640608
    147 https://doi.org/10.1101/gad.1842409
    148 https://doi.org/10.1101/gad.233585.113
    149 https://doi.org/10.1111/imr.12050
    150 https://doi.org/10.1111/j.1349-7006.2005.00015.x
    151 https://doi.org/10.1111/j.1365-2796.2009.02191.x
    152 https://doi.org/10.1111/j.1582-4934.2008.00556.x
    153 https://doi.org/10.1126/science.1113329
    154 https://doi.org/10.1126/science.1174334
    155 https://doi.org/10.1126/science.1189862
    156 https://doi.org/10.1126/scitranslmed.3003205
    157 https://doi.org/10.1128/aac.04220-14
    158 https://doi.org/10.1128/jvi.03631-14
    159 https://doi.org/10.1128/mcb.01222-08
    160 https://doi.org/10.1128/mcb.01395-06
    161 https://doi.org/10.1158/0008-5472.can-05-0530
    162 https://doi.org/10.1158/0008-5472.can-06-4074
    163 https://doi.org/10.1158/0008-5472.can-07-1083
    164 https://doi.org/10.1158/0008-5472.can-08-2516
    165 https://doi.org/10.1158/0008-5472.can-10-0655
    166 https://doi.org/10.1158/0008-5472.can-10-3568
    167 https://doi.org/10.1158/0008-5472.can-10-4645
    168 https://doi.org/10.1158/0008-5472.can-11-1144
    169 https://doi.org/10.1158/0008-5472.can-12-2001
    170 https://doi.org/10.1158/0008-5472.can-15-0888
    171 https://doi.org/10.1158/1535-7163.mct-08-0021
    172 https://doi.org/10.1158/1535-7163.mct-11-0152
    173 https://doi.org/10.1158/1535-7163.targ-15-c43
    174 https://doi.org/10.1158/1538-7445.am2015-397
    175 https://doi.org/10.1158/1538-7445.am2015-3976
    176 https://doi.org/10.1158/2159-8290.cd-12-0206
    177 https://doi.org/10.1158/2159-8290.cd-13-0159
    178 https://doi.org/10.1158/2159-8290.cd-15-0854
    179 https://doi.org/10.1158/2159-8290.cd-15-0893
    180 https://doi.org/10.1161/circresaha.111.244442
    181 https://doi.org/10.1161/circulationaha.111.030932
    182 https://doi.org/10.1172/jci33494
    183 https://doi.org/10.1172/jci38864
    184 https://doi.org/10.1172/jci63455
    185 https://doi.org/10.1172/jci63539
    186 https://doi.org/10.1172/jci73531
    187 https://doi.org/10.1261/rna.1034808
    188 https://doi.org/10.1261/rna.1155108
    189 https://doi.org/10.1371/journal.pone.0071637
    190 https://doi.org/10.15252/emmm.201100899
    191 https://doi.org/10.15252/emmm.201303604
    192 https://doi.org/10.15252/emmm.201404046
    193 https://doi.org/10.1681/asn.2011050485
    194 https://doi.org/10.2337/db09-1736
    195 https://doi.org/10.2337/db10-1557
    196 https://doi.org/10.2337/db11-1086
    197 https://doi.org/10.2459/jcm.0000000000000246
    198 https://doi.org/10.3389/fgene.2012.00120
    199 https://doi.org/10.3892/ijo.2013.1935
    200 https://doi.org/10.4161/19420862.2014.985952
    201 https://doi.org/10.4161/cc.6.13.4436
    202 https://doi.org/10.5732/cjc.011.10186
    203 https://doi.org/10.7554/elife.05005
    204 schema:datePublished 2017-03
    205 schema:datePublishedReg 2017-03-01
    206 schema:description In just over two decades since the discovery of the first microRNA (miRNA), the field of miRNA biology has expanded considerably. Insights into the roles of miRNAs in development and disease, particularly in cancer, have made miRNAs attractive tools and targets for novel therapeutic approaches. Functional studies have confirmed that miRNA dysregulation is causal in many cases of cancer, with miRNAs acting as tumour suppressors or oncogenes (oncomiRs), and miRNA mimics and molecules targeted at miRNAs (antimiRs) have shown promise in preclinical development. Several miRNA-targeted therapeutics have reached clinical development, including a mimic of the tumour suppressor miRNA miR-34, which reached phase I clinical trials for treating cancer, and antimiRs targeted at miR-122, which reached phase II trials for treating hepatitis. In this article, we describe recent advances in our understanding of miRNAs in cancer and in other diseases and provide an overview of current miRNA therapeutics in the clinic. We also discuss the challenge of identifying the most efficacious therapeutic candidates and provide a perspective on achieving safe and targeted delivery of miRNA therapeutics.
    207 schema:genre research_article
    208 schema:inLanguage en
    209 schema:isAccessibleForFree false
    210 schema:isPartOf N064719a8566c4a06880d8dd49726f946
    211 N26e75406dd494f8186f5aa6b6264c0d4
    212 sg:journal.1327423
    213 schema:name MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
    214 schema:pagination 203-222
    215 schema:productId N2f7df8738a264c699c977cc04bbd9781
    216 Nd70f6b24787b4afe9311e8b8891f6bad
    217 Ndec6c79512874831b64a6cc0dc417f49
    218 Nfdf32f68233b41f7b6a37305832a22b5
    219 Nfe4710fb063b4a0e81ae94d79a2dfced
    220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083845449
    221 https://doi.org/10.1038/nrd.2016.246
    222 schema:sdDatePublished 2019-04-11T00:04
    223 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    224 schema:sdPublisher N7eea468648a94ce38dec15ba2a8638f6
    225 schema:url http://www.nature.com/nrd/journal/v16/n3/full/nrd.2016.246.html
    226 sgo:license sg:explorer/license/
    227 sgo:sdDataset articles
    228 rdf:type schema:ScholarlyArticle
    229 N064719a8566c4a06880d8dd49726f946 schema:issueNumber 3
    230 rdf:type schema:PublicationIssue
    231 N1110a7b92eaf43cf93e5e92ffc376677 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    232 schema:name Humans
    233 rdf:type schema:DefinedTerm
    234 N19a6db51a4c545418b752ea23d61c6de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    235 schema:name Disease Management
    236 rdf:type schema:DefinedTerm
    237 N2646691946574652a048bdb7e18cc2f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    238 schema:name Animals
    239 rdf:type schema:DefinedTerm
    240 N26e75406dd494f8186f5aa6b6264c0d4 schema:volumeNumber 16
    241 rdf:type schema:PublicationVolume
    242 N299986c261ca4ba493909c2e22a29418 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    243 schema:name Genetic Therapy
    244 rdf:type schema:DefinedTerm
    245 N2f7df8738a264c699c977cc04bbd9781 schema:name readcube_id
    246 schema:value 87045b0973c1f04245b99823260e68ace078f2e8cc83e5de40799b87de52517e
    247 rdf:type schema:PropertyValue
    248 N5ae25eb697e747608bc44dcb0ce27f7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    249 schema:name Clinical Trials as Topic
    250 rdf:type schema:DefinedTerm
    251 N6889af1d608343c8b02f688da615e4db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    252 schema:name MicroRNAs
    253 rdf:type schema:DefinedTerm
    254 N7eea468648a94ce38dec15ba2a8638f6 schema:name Springer Nature - SN SciGraph project
    255 rdf:type schema:Organization
    256 Na71373c87a6b446580e5a8e9e43e23f7 rdf:first sg:person.011034742527.70
    257 rdf:rest Ne7c5b62bf5b14cc1924dd7d733147d65
    258 Nd1618f247d8b4d1ba82e6d4125752080 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    259 schema:name Neoplasms
    260 rdf:type schema:DefinedTerm
    261 Nd70f6b24787b4afe9311e8b8891f6bad schema:name nlm_unique_id
    262 schema:value 101124171
    263 rdf:type schema:PropertyValue
    264 Ndec6c79512874831b64a6cc0dc417f49 schema:name doi
    265 schema:value 10.1038/nrd.2016.246
    266 rdf:type schema:PropertyValue
    267 Ne7c5b62bf5b14cc1924dd7d733147d65 rdf:first sg:person.01172402025.03
    268 rdf:rest rdf:nil
    269 Nfdf32f68233b41f7b6a37305832a22b5 schema:name dimensions_id
    270 schema:value pub.1083845449
    271 rdf:type schema:PropertyValue
    272 Nfe4710fb063b4a0e81ae94d79a2dfced schema:name pubmed_id
    273 schema:value 28209991
    274 rdf:type schema:PropertyValue
    275 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    276 schema:name Medical and Health Sciences
    277 rdf:type schema:DefinedTerm
    278 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    279 schema:name Oncology and Carcinogenesis
    280 rdf:type schema:DefinedTerm
    281 sg:grant.2481339 http://pending.schema.org/fundedItem sg:pub.10.1038/nrd.2016.246
    282 rdf:type schema:MonetaryGrant
    283 sg:journal.1327423 schema:issn 1474-1776
    284 1474-1784
    285 schema:name Nature Reviews Drug Discovery
    286 rdf:type schema:Periodical
    287 sg:person.011034742527.70 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    288 schema:familyName Rupaimoole
    289 schema:givenName Rajesha
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011034742527.70
    291 rdf:type schema:Person
    292 sg:person.01172402025.03 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    293 schema:familyName Slack
    294 schema:givenName Frank J.
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172402025.03
    296 rdf:type schema:Person
    297 sg:pub.10.1007/s00432-011-1058-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026363766
    298 https://doi.org/10.1007/s00432-011-1058-1
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1007/s10238-012-0186-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034548550
    301 https://doi.org/10.1007/s10238-012-0186-5
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1007/s10555-007-9055-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049789382
    304 https://doi.org/10.1007/s10555-007-9055-1
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1007/s12265-010-9169-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049807798
    307 https://doi.org/10.1007/s12265-010-9169-7
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1007/s13277-011-0179-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016287237
    310 https://doi.org/10.1007/s13277-011-0179-0
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/35002607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047689840
    313 https://doi.org/10.1038/35002607
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/35040556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041493395
    316 https://doi.org/10.1038/35040556
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/cdd.2010.119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018667507
    319 https://doi.org/10.1038/cdd.2010.119
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/cdd.2013.125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016946790
    322 https://doi.org/10.1038/cdd.2013.125
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/cdd.2014.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040889995
    325 https://doi.org/10.1038/cdd.2014.87
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/leu.2013.246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020966033
    328 https://doi.org/10.1038/leu.2013.246
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/modpathol.2015.149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043394938
    331 https://doi.org/10.1038/modpathol.2015.149
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/nature01322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019336134
    334 https://doi.org/10.1038/nature01322
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/nature03677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045691844
    337 https://doi.org/10.1038/nature03677
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/nature04303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045870087
    340 https://doi.org/10.1038/nature04303
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/nature06174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014546686
    343 https://doi.org/10.1038/nature06174
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/nature06783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031121151
    346 https://doi.org/10.1038/nature06783
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/nature07511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028723946
    349 https://doi.org/10.1038/nature07511
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/nature08195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007963177
    352 https://doi.org/10.1038/nature08195
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/nature08956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035909146
    355 https://doi.org/10.1038/nature08956
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/nature09284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024444585
    358 https://doi.org/10.1038/nature09284
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/nature09459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004880322
    361 https://doi.org/10.1038/nature09459
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/nature10112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019252906
    364 https://doi.org/10.1038/nature10112
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/nature10486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029059457
    367 https://doi.org/10.1038/nature10486
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1038/nature11739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019521277
    370 https://doi.org/10.1038/nature11739
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1038/nature12080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028846082
    373 https://doi.org/10.1038/nature12080
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1038/nature13905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039740519
    376 https://doi.org/10.1038/nature13905
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.1038/nbt.1618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024956742
    379 https://doi.org/10.1038/nbt.1618
    380 rdf:type schema:CreativeWork
    381 sg:pub.10.1038/ncb1722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047429448
    382 https://doi.org/10.1038/ncb1722
    383 rdf:type schema:CreativeWork
    384 sg:pub.10.1038/ncb2396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053604598
    385 https://doi.org/10.1038/ncb2396
    386 rdf:type schema:CreativeWork
    387 sg:pub.10.1038/nchembio.1713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015713857
    388 https://doi.org/10.1038/nchembio.1713
    389 rdf:type schema:CreativeWork
    390 sg:pub.10.1038/ncomms3427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049966583
    391 https://doi.org/10.1038/ncomms3427
    392 rdf:type schema:CreativeWork
    393 sg:pub.10.1038/ncomms5802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003663410
    394 https://doi.org/10.1038/ncomms5802
    395 rdf:type schema:CreativeWork
    396 sg:pub.10.1038/ncomms6202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052126699
    397 https://doi.org/10.1038/ncomms6202
    398 rdf:type schema:CreativeWork
    399 sg:pub.10.1038/ncomms6203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025818132
    400 https://doi.org/10.1038/ncomms6203
    401 rdf:type schema:CreativeWork
    402 sg:pub.10.1038/ng.3564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053389438
    403 https://doi.org/10.1038/ng.3564
    404 rdf:type schema:CreativeWork
    405 sg:pub.10.1038/ng.915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052685738
    406 https://doi.org/10.1038/ng.915
    407 rdf:type schema:CreativeWork
    408 sg:pub.10.1038/ng1855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027542691
    409 https://doi.org/10.1038/ng1855
    410 rdf:type schema:CreativeWork
    411 sg:pub.10.1038/nm.2284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051843869
    412 https://doi.org/10.1038/nm.2284
    413 rdf:type schema:CreativeWork
    414 sg:pub.10.1038/nm.3862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032144824
    415 https://doi.org/10.1038/nm.3862
    416 rdf:type schema:CreativeWork
    417 sg:pub.10.1038/nrc3239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047946992
    418 https://doi.org/10.1038/nrc3239
    419 rdf:type schema:CreativeWork
    420 sg:pub.10.1038/nrc3447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028690550
    421 https://doi.org/10.1038/nrc3447
    422 rdf:type schema:CreativeWork
    423 sg:pub.10.1038/nrc3932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012737365
    424 https://doi.org/10.1038/nrc3932
    425 rdf:type schema:CreativeWork
    426 sg:pub.10.1038/nrd3864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000522206
    427 https://doi.org/10.1038/nrd3864
    428 rdf:type schema:CreativeWork
    429 sg:pub.10.1038/nrd4359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023956879
    430 https://doi.org/10.1038/nrd4359
    431 rdf:type schema:CreativeWork
    432 sg:pub.10.1038/nrg3074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010854443
    433 https://doi.org/10.1038/nrg3074
    434 rdf:type schema:CreativeWork
    435 sg:pub.10.1038/nrm3838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014084316
    436 https://doi.org/10.1038/nrm3838
    437 rdf:type schema:CreativeWork
    438 sg:pub.10.1038/onc.2011.263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030237115
    439 https://doi.org/10.1038/onc.2011.263
    440 rdf:type schema:CreativeWork
    441 sg:pub.10.1038/onc.2011.571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028508342
    442 https://doi.org/10.1038/onc.2011.571
    443 rdf:type schema:CreativeWork
    444 sg:pub.10.1038/onc.2012.636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007355288
    445 https://doi.org/10.1038/onc.2012.636
    446 rdf:type schema:CreativeWork
    447 sg:pub.10.1038/onc.2014.254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041745187
    448 https://doi.org/10.1038/onc.2014.254
    449 rdf:type schema:CreativeWork
    450 sg:pub.10.1038/onc.2015.492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047665213
    451 https://doi.org/10.1038/onc.2015.492
    452 rdf:type schema:CreativeWork
    453 sg:pub.10.1038/sj.onc.1210856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052742288
    454 https://doi.org/10.1038/sj.onc.1210856
    455 rdf:type schema:CreativeWork
    456 sg:pub.10.1038/srep01942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042341369
    457 https://doi.org/10.1038/srep01942
    458 rdf:type schema:CreativeWork
    459 sg:pub.10.1038/srep02038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048494691
    460 https://doi.org/10.1038/srep02038
    461 rdf:type schema:CreativeWork
    462 sg:pub.10.1186/s12943-016-0525-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042826609
    463 https://doi.org/10.1186/s12943-016-0525-3
    464 rdf:type schema:CreativeWork
    465 https://app.dimensions.ai/details/publication/pub.1074754944 schema:CreativeWork
    466 https://doi.org/10.1001/jama.297.17.1901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026824938
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1002/art.27443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007141847
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1002/emmm.201100209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022068361
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1002/humu.20750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022993449
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1002/jbm.820050305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031910318
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1002/path.4348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037296109
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1016/0092-8674(93)90529-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1051619915
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1016/j.addr.2005.09.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026857203
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1016/j.bbadis.2009.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053232130
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1016/j.bbrc.2009.02.097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023089871
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1016/j.ccr.2007.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010739271
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1016/j.ccr.2009.10.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029310321
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1016/j.ccr.2009.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049400026
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1016/j.ccr.2010.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027223734
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1016/j.ccr.2010.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034759885
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1016/j.ccr.2012.12.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023188068
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1016/j.cell.2005.01.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010338150
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1016/j.cell.2007.10.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050608753
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1016/j.cell.2008.02.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033132999
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1016/j.cell.2009.04.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011455689
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1016/j.cell.2009.10.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006059863
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1016/j.cell.2010.05.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035246723
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.1016/j.cell.2012.03.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028293119
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.1016/j.cell.2015.02.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003684444
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.1016/j.cellsig.2014.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022495924
    515 rdf:type schema:CreativeWork
    516 https://doi.org/10.1016/j.cmet.2006.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052534178
    517 rdf:type schema:CreativeWork
    518 https://doi.org/10.1016/j.ejca.2010.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044623775
    519 rdf:type schema:CreativeWork
    520 https://doi.org/10.1016/j.jconrel.2006.05.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039888012
    521 rdf:type schema:CreativeWork
    522 https://doi.org/10.1016/j.jconrel.2008.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051659714
    523 rdf:type schema:CreativeWork
    524 https://doi.org/10.1016/j.jconrel.2011.07.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021944437
    525 rdf:type schema:CreativeWork
    526 https://doi.org/10.1016/j.jconrel.2013.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002245965
    527 rdf:type schema:CreativeWork
    528 https://doi.org/10.1016/j.jmb.2008.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035553445
    529 rdf:type schema:CreativeWork
    530 https://doi.org/10.1016/j.molcel.2007.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022322235
    531 rdf:type schema:CreativeWork
    532 https://doi.org/10.1016/j.molcel.2007.05.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024011682
    533 rdf:type schema:CreativeWork
    534 https://doi.org/10.1016/j.molcel.2010.07.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037315878
    535 rdf:type schema:CreativeWork
    536 https://doi.org/10.1016/j.molcel.2011.01.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043029093
    537 rdf:type schema:CreativeWork
    538 https://doi.org/10.1016/j.stem.2013.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027338340
    539 rdf:type schema:CreativeWork
    540 https://doi.org/10.1016/j.tcb.2008.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044009500
    541 rdf:type schema:CreativeWork
    542 https://doi.org/10.1016/j.yexcr.2012.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023835661
    543 rdf:type schema:CreativeWork
    544 https://doi.org/10.1016/s0092-8674(04)00045-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031254572
    545 rdf:type schema:CreativeWork
    546 https://doi.org/10.1021/bc990072j schema:sameAs https://app.dimensions.ai/details/publication/pub.1055156465
    547 rdf:type schema:CreativeWork
    548 https://doi.org/10.1021/ja505986a schema:sameAs https://app.dimensions.ai/details/publication/pub.1040895801
    549 rdf:type schema:CreativeWork
    550 https://doi.org/10.1038/embor.2008.74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032429234
    551 rdf:type schema:CreativeWork
    552 https://doi.org/10.1038/mt.2011.48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022661211
    553 rdf:type schema:CreativeWork
    554 https://doi.org/10.1038/mt.2014.79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009500801
    555 rdf:type schema:CreativeWork
    556 https://doi.org/10.1038/mtna.2014.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000696990
    557 rdf:type schema:CreativeWork
    558 https://doi.org/10.1038/sj.emboj.7601790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011000169
    559 rdf:type schema:CreativeWork
    560 https://doi.org/10.1056/nejmoa0803785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049319966
    561 rdf:type schema:CreativeWork
    562 https://doi.org/10.1056/nejmoa0901282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002363689
    563 rdf:type schema:CreativeWork
    564 https://doi.org/10.1056/nejmoa1102903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046348995
    565 rdf:type schema:CreativeWork
    566 https://doi.org/10.1056/nejmoa1209026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026864726
    567 rdf:type schema:CreativeWork
    568 https://doi.org/10.1073/pnas.0601463103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012334818
    569 rdf:type schema:CreativeWork
    570 https://doi.org/10.1073/pnas.0703942104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023155459
    571 rdf:type schema:CreativeWork
    572 https://doi.org/10.1073/pnas.0800121105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034225351
    573 rdf:type schema:CreativeWork
    574 https://doi.org/10.1073/pnas.0804746105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010822801
    575 rdf:type schema:CreativeWork
    576 https://doi.org/10.1073/pnas.0902636106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028163409
    577 rdf:type schema:CreativeWork
    578 https://doi.org/10.1073/pnas.0907904107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045318191
    579 rdf:type schema:CreativeWork
    580 https://doi.org/10.1073/pnas.1101795108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052444338
    581 rdf:type schema:CreativeWork
    582 https://doi.org/10.1073/pnas.1102281108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026108806
    583 rdf:type schema:CreativeWork
    584 https://doi.org/10.1073/pnas.1201516109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017684729
    585 rdf:type schema:CreativeWork
    586 https://doi.org/10.1073/pnas.1317242111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047118954
    587 rdf:type schema:CreativeWork
    588 https://doi.org/10.1074/jbc.c800074200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041926183
    589 rdf:type schema:CreativeWork
    590 https://doi.org/10.1074/jbc.m110.194969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017779820
    591 rdf:type schema:CreativeWork
    592 https://doi.org/10.1074/jbc.m111.236950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037541954
    593 rdf:type schema:CreativeWork
    594 https://doi.org/10.1074/jbc.m707224200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012014539
    595 rdf:type schema:CreativeWork
    596 https://doi.org/10.1074/jbc.m800731200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029400347
    597 rdf:type schema:CreativeWork
    598 https://doi.org/10.1080/08830180903093796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050971290
    599 rdf:type schema:CreativeWork
    600 https://doi.org/10.1080/15384101.2014.1003008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058401749
    601 rdf:type schema:CreativeWork
    602 https://doi.org/10.1091/mbc.e11-02-0103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023253161
    603 rdf:type schema:CreativeWork
    604 https://doi.org/10.1093/annonc/mdv090.2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048231165
    605 rdf:type schema:CreativeWork
    606 https://doi.org/10.1093/carcin/bgn187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047490751
    607 rdf:type schema:CreativeWork
    608 https://doi.org/10.1093/jnci/djv108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031913448
    609 rdf:type schema:CreativeWork
    610 https://doi.org/10.1093/jnci/djv303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017434170
    611 rdf:type schema:CreativeWork
    612 https://doi.org/10.1093/nar/gkm1113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009727938
    613 rdf:type schema:CreativeWork
    614 https://doi.org/10.1093/nar/gkt1248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031236821
    615 rdf:type schema:CreativeWork
    616 https://doi.org/10.1093/nar/gkv1258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026886886
    617 rdf:type schema:CreativeWork
    618 https://doi.org/10.1097/hco.0000000000000280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027066036
    619 rdf:type schema:CreativeWork
    620 https://doi.org/10.1097/ppo.0b013e318258b75b schema:sameAs https://app.dimensions.ai/details/publication/pub.1044063478
    621 rdf:type schema:CreativeWork
    622 https://doi.org/10.1101/gad.1640608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004123559
    623 rdf:type schema:CreativeWork
    624 https://doi.org/10.1101/gad.1842409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000762433
    625 rdf:type schema:CreativeWork
    626 https://doi.org/10.1101/gad.233585.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025118252
    627 rdf:type schema:CreativeWork
    628 https://doi.org/10.1111/imr.12050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018294988
    629 rdf:type schema:CreativeWork
    630 https://doi.org/10.1111/j.1349-7006.2005.00015.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007310658
    631 rdf:type schema:CreativeWork
    632 https://doi.org/10.1111/j.1365-2796.2009.02191.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052253625
    633 rdf:type schema:CreativeWork
    634 https://doi.org/10.1111/j.1582-4934.2008.00556.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026654179
    635 rdf:type schema:CreativeWork
    636 https://doi.org/10.1126/science.1113329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023422868
    637 rdf:type schema:CreativeWork
    638 https://doi.org/10.1126/science.1174334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062460178
    639 rdf:type schema:CreativeWork
    640 https://doi.org/10.1126/science.1189862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062461810
    641 rdf:type schema:CreativeWork
    642 https://doi.org/10.1126/scitranslmed.3003205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052341351
    643 rdf:type schema:CreativeWork
    644 https://doi.org/10.1128/aac.04220-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053531138
    645 rdf:type schema:CreativeWork
    646 https://doi.org/10.1128/jvi.03631-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014709518
    647 rdf:type schema:CreativeWork
    648 https://doi.org/10.1128/mcb.01222-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011818148
    649 rdf:type schema:CreativeWork
    650 https://doi.org/10.1128/mcb.01395-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027701800
    651 rdf:type schema:CreativeWork
    652 https://doi.org/10.1158/0008-5472.can-05-0530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030443527
    653 rdf:type schema:CreativeWork
    654 https://doi.org/10.1158/0008-5472.can-06-4074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006514003
    655 rdf:type schema:CreativeWork
    656 https://doi.org/10.1158/0008-5472.can-07-1083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018927559
    657 rdf:type schema:CreativeWork
    658 https://doi.org/10.1158/0008-5472.can-08-2516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028573658
    659 rdf:type schema:CreativeWork
    660 https://doi.org/10.1158/0008-5472.can-10-0655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041015690
    661 rdf:type schema:CreativeWork
    662 https://doi.org/10.1158/0008-5472.can-10-3568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002661412
    663 rdf:type schema:CreativeWork
    664 https://doi.org/10.1158/0008-5472.can-10-4645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039600044
    665 rdf:type schema:CreativeWork
    666 https://doi.org/10.1158/0008-5472.can-11-1144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021573821
    667 rdf:type schema:CreativeWork
    668 https://doi.org/10.1158/0008-5472.can-12-2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051005493
    669 rdf:type schema:CreativeWork
    670 https://doi.org/10.1158/0008-5472.can-15-0888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063215812
    671 rdf:type schema:CreativeWork
    672 https://doi.org/10.1158/1535-7163.mct-08-0021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000376245
    673 rdf:type schema:CreativeWork
    674 https://doi.org/10.1158/1535-7163.mct-11-0152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025758379
    675 rdf:type schema:CreativeWork
    676 https://doi.org/10.1158/1535-7163.targ-15-c43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063229575
    677 rdf:type schema:CreativeWork
    678 https://doi.org/10.1158/1538-7445.am2015-397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063262782
    679 rdf:type schema:CreativeWork
    680 https://doi.org/10.1158/1538-7445.am2015-3976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063262789
    681 rdf:type schema:CreativeWork
    682 https://doi.org/10.1158/2159-8290.cd-12-0206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002738808
    683 rdf:type schema:CreativeWork
    684 https://doi.org/10.1158/2159-8290.cd-13-0159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017778945
    685 rdf:type schema:CreativeWork
    686 https://doi.org/10.1158/2159-8290.cd-15-0854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027069464
    687 rdf:type schema:CreativeWork
    688 https://doi.org/10.1158/2159-8290.cd-15-0893 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020615054
    689 rdf:type schema:CreativeWork
    690 https://doi.org/10.1161/circresaha.111.244442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004295163
    691 rdf:type schema:CreativeWork
    692 https://doi.org/10.1161/circulationaha.111.030932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004700361
    693 rdf:type schema:CreativeWork
    694 https://doi.org/10.1172/jci33494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063417065
    695 rdf:type schema:CreativeWork
    696 https://doi.org/10.1172/jci38864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006895222
    697 rdf:type schema:CreativeWork
    698 https://doi.org/10.1172/jci63455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012337417
    699 rdf:type schema:CreativeWork
    700 https://doi.org/10.1172/jci63539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030233492
    701 rdf:type schema:CreativeWork
    702 https://doi.org/10.1172/jci73531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002954873
    703 rdf:type schema:CreativeWork
    704 https://doi.org/10.1261/rna.1034808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017884514
    705 rdf:type schema:CreativeWork
    706 https://doi.org/10.1261/rna.1155108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048224171
    707 rdf:type schema:CreativeWork
    708 https://doi.org/10.1371/journal.pone.0071637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039290073
    709 rdf:type schema:CreativeWork
    710 https://doi.org/10.15252/emmm.201100899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045530046
    711 rdf:type schema:CreativeWork
    712 https://doi.org/10.15252/emmm.201303604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050816814
    713 rdf:type schema:CreativeWork
    714 https://doi.org/10.15252/emmm.201404046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042497801
    715 rdf:type schema:CreativeWork
    716 https://doi.org/10.1681/asn.2011050485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051897121
    717 rdf:type schema:CreativeWork
    718 https://doi.org/10.2337/db09-1736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011195928
    719 rdf:type schema:CreativeWork
    720 https://doi.org/10.2337/db10-1557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035227761
    721 rdf:type schema:CreativeWork
    722 https://doi.org/10.2337/db11-1086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008363834
    723 rdf:type schema:CreativeWork
    724 https://doi.org/10.2459/jcm.0000000000000246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040540990
    725 rdf:type schema:CreativeWork
    726 https://doi.org/10.3389/fgene.2012.00120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050939524
    727 rdf:type schema:CreativeWork
    728 https://doi.org/10.3892/ijo.2013.1935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071513132
    729 rdf:type schema:CreativeWork
    730 https://doi.org/10.4161/19420862.2014.985952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072288697
    731 rdf:type schema:CreativeWork
    732 https://doi.org/10.4161/cc.6.13.4436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072299006
    733 rdf:type schema:CreativeWork
    734 https://doi.org/10.5732/cjc.011.10186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042024650
    735 rdf:type schema:CreativeWork
    736 https://doi.org/10.7554/elife.05005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046247280
    737 rdf:type schema:CreativeWork
    738 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
    739 schema:name Institute for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center Cancer Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
    740 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...