Treating cancer with selective CDK4/6 inhibitors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-07

AUTHORS

Ben O'Leary, Richard S. Finn, Nicholas C. Turner

ABSTRACT

Uncontrolled cellular proliferation, mediated by dysregulation of the cell-cycle machinery and activation of cyclin-dependent kinases (CDKs) to promote cell-cycle progression, lies at the heart of cancer as a pathological process. Clinical implementation of first-generation, nonselective CDK inhibitors, designed to inhibit this proliferation, was originally hampered by the high risk of toxicity and lack of efficacy noted with these agents. The emergence of a new generation of selective CDK4/6 inhibitors, including ribociclib, abemaciclib and palbociclib, has enabled tumour types in which CDK4/6 has a pivotal role in the G1-to-S-phase cell-cycle transition to be targeted with improved effectiveness, and fewer adverse effects. Results of pivotal phase III trials investigating palbociclib in patients with advanced-stage oestrogen receptor (ER)-positive breast cancer have demonstrated a substantial improvement in progression-free survival, with a well-tolerated toxicity profile. Mechanisms of acquired resistance to CDK4/6 inhibitors are beginning to emerge that, although unwelcome, might enable rational post-CDK4/6 inhibitor therapeutic strategies to be identified. Extending the use of CDK4/6 inhibitors beyond ER-positive breast cancer is challenging, and will likely require biomarkers that are predictive of a response, and the use of combination therapies in order to optimize CDK4/6 targeting. More... »

PAGES

417-430

References to SciGraph publications

  • 2001-06. Specific protection against breast cancers by cyclin D1 ablation in NATURE
  • 2011-08. Cyclin D as a therapeutic target in cancer in NATURE REVIEWS CANCER
  • 1997-04. Interaction between Cdc37 and Cdk4 in human cells in ONCOGENE
  • 2002-12. NOBEL LECTURE: Cyclin Dependent Kinases and Cell Cycle Control in BIOSCIENCE REPORTS
  • 1995-06. Mechanism of active transcriptional repression by the retinoblastoma protein in NATURE
  • 1994-09. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma in NATURE GENETICS
  • 2009-10. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro in BREAST CANCER RESEARCH
  • 2003-08. Genetic rescue of Cdk4 null mice restores pancreatic β-cell proliferation but not homeostatic cell number in ONCOGENE
  • 2001-11. 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes in NATURE
  • 2009-03. Cell cycle, CDKs and cancer: a changing paradigm in NATURE REVIEWS CANCER
  • 1999-01. p16INK4 mediates contact-inhibition of growth in ONCOGENE
  • 1995-10. Frequency of homozygous deletion at p16/CDKN2 in primary human tumours in NATURE GENETICS
  • 2010-08. Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy in NATURE GENETICS
  • 1996-02. Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer in BRITISH JOURNAL OF CANCER
  • 1995-12. Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions in NATURE MEDICINE
  • 2007-01. A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days in BRITISH JOURNAL OF CANCER
  • 2008-09. CDK8 is a colorectal cancer oncogene that regulates β-catenin activity in NATURE
  • 2008-10. The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas in BREAST CANCER RESEARCH
  • 1999-05. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia in NATURE GENETICS
  • 2012-09-23. Comprehensive molecular portraits of human breast tumours in NATURE
  • 2013-12. ESR1 ligand-binding domain mutations in hormone-resistant breast cancer in NATURE GENETICS
  • 2011-06. Phase I study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (Schedule 2/1) in BRITISH JOURNAL OF CANCER
  • 1994-09. pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest in NATURE
  • 2013-12. Activating ESR1 mutations in hormone-resistant metastatic breast cancer in NATURE GENETICS
  • 2007-08. Cdk1 is sufficient to drive the mammalian cell cycle in NATURE
  • 1992-07. Retinoblastoma protein switches the E2F site from positive to negative element in NATURE
  • 2012-10. Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma in NATURE MEDICINE
  • 1999-02. Level of retinoblastoma protein expression correlates with p16 (MTS-1/INK4A/CDKN2) status in bladder cancer in ONCOGENE
  • 2009-07. Cell cycle kinases as therapeutic targets for cancer in NATURE REVIEWS DRUG DISCOVERY
  • 1990-08. Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B in NATURE
  • 1991-09. Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase in NATURE
  • 1994-09. Germline p16 mutations in familial melanoma in NATURE GENETICS
  • 2004-11. Cell-cycle checkpoints and cancer in NATURE
  • 1997-03. Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein in NATURE
  • 1996-01. Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma in NATURE GENETICS
  • 2001-11. The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription in NATURE
  • 2013-11. Targeting cell cycle and hormone receptor pathways in cancer in ONCOGENE
  • 2015-02. The history and future of targeting cyclin-dependent kinases in cancer therapy in NATURE REVIEWS DRUG DISCOVERY
  • 1993-12. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 in NATURE
  • 1998-07. Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1 in NATURE
  • 2014-10. Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine in INVESTIGATIONAL NEW DRUGS
  • 2002-12. The retinoblastoma tumour suppressor in development and cancer in NATURE REVIEWS CANCER
  • 2000-02. Individuals with presumably hereditary uveal melanoma do not harbour germline mutations in the coding regions of either the P16INK4A, P14ARF or cdk4 genes in BRITISH JOURNAL OF CANCER
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1038/nrclinonc.2016.26

    DOI

    http://dx.doi.org/10.1038/nrclinonc.2016.26

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031060512

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27030077


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