Paradoxical oncogenesis—the long-term effects of BRAF inhibition in melanoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-07

AUTHORS

Geoffrey T. Gibney, Jane L. Messina, Inna V. Fedorenko, Vernon K. Sondak, Keiran S. M. Smalley

ABSTRACT

The clinical benefits of BRAF inhibition in patients with advanced-stage BRAF-mutant melanoma are now well established. Although the emergence of cutaneous squamous-cell carcinomas (SCCs) and secondary melanomas in patients on BRAF-inhibitor therapy have been well described, reports are emerging of additional secondary premalignant and malignant events, including RAS-mutant leukaemia, the metastatic recurrence of RAS-mutant colorectal cancer and the development of gastric and colonic polyps. In most cases, paradoxical MAPK activation--resulting from the BRAF-inhibitor-mediated homodimerization and heterodimerization of nonmutant RAF isoforms--seems to underlie the development of these secondary tumours. Although evidence supports that therapy with the simultaneous administration of BRAF and MEK inhibitors abrogates the onset of treatment-induced SCCs, whether combination treatment will limit the emergence of all BRAF-inhibitor-driven pathologies is unclear. In this Review, we describe the clinical and mechanistic manifestations of secondary cancers that have thus far been observed to arise as a consequence of BRAF inhibition. We discuss the concept of pre-existing populations of partly transformed cells with malignant potential that might be present in various organ systems, and the rationale for novel therapeutic strategies for the management of BRAF-inhibitor-induced neoplasia. More... »

PAGES

390

References to SciGraph publications

  • 2012-02. Tumor control versus adverse events with targeted anticancer therapies in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2013-01. Skin cancer: Targeted therapy for melanoma: is double hitting a home run? in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2006-01. BRAF mutation predicts sensitivity to MEK inhibition in NATURE
  • 2010-06. ERK activation drives intestinal tumorigenesis in Apcmin/+ mice in NATURE MEDICINE
  • 2007-10. RAR and RXR modulation in cancer and metabolic disease in NATURE REVIEWS DRUG DISCOVERY
  • 2012-03. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR in NATURE
  • 2011-10. Small Bowel Polyposis Syndromes in CURRENT GASTROENTEROLOGY REPORTS
  • 2010-09. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma in NATURE
  • 2004-11. The RAF proteins take centre stage in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2002-06. Mutations of the BRAF gene in human cancer in NATURE
  • 2011-01. Hyperactivation of MEK–ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells in ONCOGENE
  • 2010-06. Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy in BRITISH JOURNAL OF CANCER
  • 1996-09. Oligomerization activates c-Raf-1 through a Ras-dependent mechanism in NATURE
  • 2010-03-18. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth in NATURE
  • 2010-03-18. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF in NATURE
  • 2009-06. The Current Spectrum of Gastric Polyps: A 1-Year National Study of over 120,000 Patients in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2003-06. RAS oncogenes: the first 30 years in NATURE REVIEWS CANCER
  • 2009-06. Management of gastric polyps: a pathology-based guide for gastroenterologists in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2010-12. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation in NATURE
  • 2012-01. Melanoma whole-exome sequencing identifies V600EB-RAF amplification-mediated acquired B-RAF inhibitor resistance in NATURE COMMUNICATIONS
  • 2011-12. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E) in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrclinonc.2013.83

    DOI

    http://dx.doi.org/10.1038/nrclinonc.2013.83

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024794345

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23712190


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Transformation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Melanoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins B-raf", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Moffitt Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.468198.a", 
              "name": [
                "Department of Cutaneous Oncology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gibney", 
            "givenName": "Geoffrey T.", 
            "id": "sg:person.01065153434.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065153434.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of South Florida", 
              "id": "https://www.grid.ac/institutes/grid.170693.a", 
              "name": [
                "Department of Pathology and Cell Biology, University of South Florida College of Medicine, 12901 Bruce B. Downs Boulevard, MDC 11, Tampa, FL 33612, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Messina", 
            "givenName": "Jane L.", 
            "id": "sg:person.01104010437.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104010437.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Moffitt Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.468198.a", 
              "name": [
                "Department of Molecular Oncology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fedorenko", 
            "givenName": "Inna V.", 
            "id": "sg:person.01274732656.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274732656.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Moffitt Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.468198.a", 
              "name": [
                "Department of Cutaneous Oncology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sondak", 
            "givenName": "Vernon K.", 
            "id": "sg:person.0725307737.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725307737.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Moffitt Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.468198.a", 
              "name": [
                "Department of Molecular Oncology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Smalley", 
            "givenName": "Keiran S. M.", 
            "id": "sg:person.07642674137.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07642674137.95"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrclinonc.2012.215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000243646", 
              "https://doi.org/10.1038/nrclinonc.2012.215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2011.41.1660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000408054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(97)10111-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001133027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(12)60868-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003772891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1940-6207.capr-08-0206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004457633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1755-148x.2012.00981.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004899602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0058721", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005168367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1105358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006141094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(12)70413-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006760591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006916541", 
              "https://doi.org/10.1038/nature08902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006916541", 
              "https://doi.org/10.1038/nature08902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-03-3433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007018612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-03-3433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007018612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2012.03.067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008408030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2011.39.8594", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009260124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009288742", 
              "https://doi.org/10.1038/nature08833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009288742", 
              "https://doi.org/10.1038/nature08833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2011.192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009594521", 
              "https://doi.org/10.1038/nrclinonc.2011.192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-11-1491", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009764558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.26.6.2262-2272.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009784412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.408", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011149116", 
              "https://doi.org/10.1038/onc.2010.408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-11-3747", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011377387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms1727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011476380", 
              "https://doi.org/10.1038/ncomms1727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaad.2008.06.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011791387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/16.13.3797", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012071604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012130507", 
              "https://doi.org/10.1038/nature04304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012130507", 
              "https://doi.org/10.1038/nature04304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012130507", 
              "https://doi.org/10.1038/nature04304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1002011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012824919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bcp.2011.05.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013269526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605714", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013296980", 
              "https://doi.org/10.1038/sj.bjc.6605714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81333-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014745301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(12)60398-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015389206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2009.139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016038883", 
              "https://doi.org/10.1038/ajg.2009.139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2009.139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016038883", 
              "https://doi.org/10.1038/ajg.2009.139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2011.36.7680", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016636989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci65780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016683402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1755-148x.2010.00685.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017083437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018115916", 
              "https://doi.org/10.1038/nrd2397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/pcmr.12092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018424257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c2mb25393c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018701259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(04)00215-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019563286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2005.06.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020789267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2005.06.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020789267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.21166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021817259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1208958", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022455909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023536940", 
              "https://doi.org/10.1038/nature00766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023536940", 
              "https://doi.org/10.1038/nature00766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/theoncologist.2012-0333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023646847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrgastro.2009.70", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023847041", 
              "https://doi.org/10.1038/nrgastro.2009.70"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrgastro.2009.70", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023847041", 
              "https://doi.org/10.1038/nrgastro.2009.70"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.32.4327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027360666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-4471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027786788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.12.040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028106155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10662", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028208693", 
              "https://doi.org/10.1038/nature10662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmc1108651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029020155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgg009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029084752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m802855200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031343092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032620847", 
              "https://doi.org/10.1038/nature09454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032620847", 
              "https://doi.org/10.1038/nature09454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)62511-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032648731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032797854", 
              "https://doi.org/10.1038/nm.2143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032797854", 
              "https://doi.org/10.1038/nm.2143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(19850801)56:3<531::aid-cncr2820560321>3.0.co;2-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033058269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmc0904160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033520688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2133.2012.11155.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033639771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-3201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035602391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09626", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035733152", 
              "https://doi.org/10.1038/nature09626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1210093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036427533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2005.10.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037007117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11894-011-0218-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037027357", 
              "https://doi.org/10.1007/s11894-011-0218-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1755-148x.2008.00491.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037715578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.seminoncol.2012.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037837573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10868", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038374700", 
              "https://doi.org/10.1038/nature10868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1008990107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039016844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.33.2312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040298667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/17.5.1371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041267201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1103782", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041864150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1011-1344(01)00206-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042146010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cgh.2009.05.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043630703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-11-0341", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043663281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1464-410x.2008.07900.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044116307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/383181a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044422710", 
              "https://doi.org/10.1038/383181a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044819609", 
              "https://doi.org/10.1038/nrc1097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044819609", 
              "https://doi.org/10.1038/nrc1097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1014209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044873328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/dddt.s38998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045937080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgs349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047682503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/20.10.1939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047999324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-1440", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048145384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djq442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049373746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molonc.2013.11.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049679003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1562/0031-8655(2002)0760073ceimah2.0.co2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049929859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-11-0989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050113307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050758604", 
              "https://doi.org/10.1038/nrm1498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050758604", 
              "https://doi.org/10.1038/nrm1498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(13)70024-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051396936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1203421", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051983710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2010.10.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052124278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2012.10.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053006533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0711741105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053628579"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)00122-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053728752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1562/0031-8655(2002)076<0073:ceimah>2.0.co;2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068006923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075262313", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmc1108651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078462624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2012.30.18_suppl.lba8509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083397228"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-07", 
        "datePublishedReg": "2013-07-01", 
        "description": "The clinical benefits of BRAF inhibition in patients with advanced-stage BRAF-mutant melanoma are now well established. Although the emergence of cutaneous squamous-cell carcinomas (SCCs) and secondary melanomas in patients on BRAF-inhibitor therapy have been well described, reports are emerging of additional secondary premalignant and malignant events, including RAS-mutant leukaemia, the metastatic recurrence of RAS-mutant colorectal cancer and the development of gastric and colonic polyps. In most cases, paradoxical MAPK activation--resulting from the BRAF-inhibitor-mediated homodimerization and heterodimerization of nonmutant RAF isoforms--seems to underlie the development of these secondary tumours. Although evidence supports that therapy with the simultaneous administration of BRAF and MEK inhibitors abrogates the onset of treatment-induced SCCs, whether combination treatment will limit the emergence of all BRAF-inhibitor-driven pathologies is unclear. In this Review, we describe the clinical and mechanistic manifestations of secondary cancers that have thus far been observed to arise as a consequence of BRAF inhibition. We discuss the concept of pre-existing populations of partly transformed cells with malignant potential that might be present in various organ systems, and the rationale for novel therapeutic strategies for the management of BRAF-inhibitor-induced neoplasia.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nrclinonc.2013.83", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2699085", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2481570", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1034153", 
            "issn": [
              "1759-4774", 
              "1759-4782"
            ], 
            "name": "Nature Reviews Clinical Oncology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "name": "Paradoxical oncogenesis\u2014the long-term effects of BRAF inhibition in melanoma", 
        "pagination": "390", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "761ed9b780f05b56ff681525e04111c04496a083440b8e4944ada835a47113fa"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23712190"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101500077"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrclinonc.2013.83"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1024794345"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrclinonc.2013.83", 
          "https://app.dimensions.ai/details/publication/pub.1024794345"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T22:20", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000435.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nrclinonc.2013.83"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrclinonc.2013.83'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrclinonc.2013.83'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrclinonc.2013.83'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrclinonc.2013.83'


     

    This table displays all metadata directly associated to this object as RDF triples.

    426 TRIPLES      21 PREDICATES      127 URIs      27 LITERALS      15 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrclinonc.2013.83 schema:about N2619c2d8a23c4ec4975c8aaaf4a9d7f6
    2 N4510f2a595584632b8c5bdd919d60c0c
    3 N6736a6cde7054d33a78115c39b3e577a
    4 N97b956b671764049a5e496db3a982cf3
    5 Ne6f60d6fea3f422695de05ad0f89aa11
    6 Neb2ebe0da84f43019a5285d5f209d4e0
    7 anzsrc-for:11
    8 anzsrc-for:1112
    9 schema:author Nee818b87c0774fe2ac45bc584a5a973a
    10 schema:citation sg:pub.10.1007/s11894-011-0218-4
    11 sg:pub.10.1038/383181a0
    12 sg:pub.10.1038/ajg.2009.139
    13 sg:pub.10.1038/nature00766
    14 sg:pub.10.1038/nature04304
    15 sg:pub.10.1038/nature08833
    16 sg:pub.10.1038/nature08902
    17 sg:pub.10.1038/nature09454
    18 sg:pub.10.1038/nature09626
    19 sg:pub.10.1038/nature10662
    20 sg:pub.10.1038/nature10868
    21 sg:pub.10.1038/ncomms1727
    22 sg:pub.10.1038/nm.2143
    23 sg:pub.10.1038/nrc1097
    24 sg:pub.10.1038/nrclinonc.2011.192
    25 sg:pub.10.1038/nrclinonc.2012.215
    26 sg:pub.10.1038/nrd2397
    27 sg:pub.10.1038/nrgastro.2009.70
    28 sg:pub.10.1038/nrm1498
    29 sg:pub.10.1038/onc.2010.408
    30 sg:pub.10.1038/sj.bjc.6605714
    31 https://app.dimensions.ai/details/publication/pub.1075262313
    32 https://doi.org/10.1002/1097-0142(19850801)56:3<531::aid-cncr2820560321>3.0.co;2-3
    33 https://doi.org/10.1016/j.bcp.2011.05.015
    34 https://doi.org/10.1016/j.ccr.2010.10.029
    35 https://doi.org/10.1016/j.ccr.2012.10.009
    36 https://doi.org/10.1016/j.cell.2009.12.040
    37 https://doi.org/10.1016/j.cgh.2009.05.032
    38 https://doi.org/10.1016/j.cub.2012.03.067
    39 https://doi.org/10.1016/j.jaad.2008.06.034
    40 https://doi.org/10.1016/j.molcel.2005.06.009
    41 https://doi.org/10.1016/j.molcel.2005.10.022
    42 https://doi.org/10.1016/j.molonc.2013.11.005
    43 https://doi.org/10.1016/s0002-9440(10)62511-4
    44 https://doi.org/10.1016/s0092-8674(00)00122-7
    45 https://doi.org/10.1016/s0092-8674(00)81333-1
    46 https://doi.org/10.1016/s0092-8674(04)00215-6
    47 https://doi.org/10.1016/s0140-6736(12)60398-5
    48 https://doi.org/10.1016/s0140-6736(12)60868-x
    49 https://doi.org/10.1016/s0959-8049(97)10111-3
    50 https://doi.org/10.1016/s1011-1344(01)00206-8
    51 https://doi.org/10.1016/s1470-2045(12)70413-8
    52 https://doi.org/10.1016/s1470-2045(13)70024-x
    53 https://doi.org/10.1039/c2mb25393c
    54 https://doi.org/10.1053/j.seminoncol.2012.01.001
    55 https://doi.org/10.1056/nejmc0904160
    56 https://doi.org/10.1056/nejmc1108651
    57 https://doi.org/10.1056/nejmoa1002011
    58 https://doi.org/10.1056/nejmoa1014209
    59 https://doi.org/10.1056/nejmoa1103782
    60 https://doi.org/10.1056/nejmoa1105358
    61 https://doi.org/10.1056/nejmoa1203421
    62 https://doi.org/10.1056/nejmoa1208958
    63 https://doi.org/10.1056/nejmoa1210093
    64 https://doi.org/10.1073/pnas.0711741105
    65 https://doi.org/10.1073/pnas.1008990107
    66 https://doi.org/10.1074/jbc.m802855200
    67 https://doi.org/10.1093/carcin/20.10.1939
    68 https://doi.org/10.1093/carcin/bgg009
    69 https://doi.org/10.1093/carcin/bgs349
    70 https://doi.org/10.1093/emboj/16.13.3797
    71 https://doi.org/10.1093/emboj/17.5.1371
    72 https://doi.org/10.1093/jnci/djq442
    73 https://doi.org/10.1111/j.1365-2133.2012.11155.x
    74 https://doi.org/10.1111/j.1464-410x.2008.07900.x
    75 https://doi.org/10.1111/j.1755-148x.2008.00491.x
    76 https://doi.org/10.1111/j.1755-148x.2010.00685.x
    77 https://doi.org/10.1111/j.1755-148x.2012.00981.x
    78 https://doi.org/10.1111/pcmr.12092
    79 https://doi.org/10.1128/mcb.26.6.2262-2272.2006
    80 https://doi.org/10.1158/0008-5472.can-03-3433
    81 https://doi.org/10.1158/0008-5472.can-08-3201
    82 https://doi.org/10.1158/0008-5472.can-09-4471
    83 https://doi.org/10.1158/0008-5472.can-11-3747
    84 https://doi.org/10.1158/1078-0432.ccr-07-1440
    85 https://doi.org/10.1158/1078-0432.ccr-11-1491
    86 https://doi.org/10.1158/1535-7163.mct-11-0989
    87 https://doi.org/10.1158/1940-6207.capr-08-0206
    88 https://doi.org/10.1158/2159-8290.cd-11-0341
    89 https://doi.org/10.1172/jci65780
    90 https://doi.org/10.1200/jco.2010.32.4327
    91 https://doi.org/10.1200/jco.2010.33.2312
    92 https://doi.org/10.1200/jco.2011.36.7680
    93 https://doi.org/10.1200/jco.2011.39.8594
    94 https://doi.org/10.1200/jco.2011.41.1660
    95 https://doi.org/10.1200/jco.2012.30.18_suppl.lba8509
    96 https://doi.org/10.1371/journal.pone.0058721
    97 https://doi.org/10.1562/0031-8655(2002)0760073ceimah2.0.co2
    98 https://doi.org/10.1562/0031-8655(2002)076<0073:ceimah>2.0.co;2
    99 https://doi.org/10.1634/theoncologist.2012-0333
    100 https://doi.org/10.2147/dddt.s38998
    101 https://doi.org/10.3322/caac.21166
    102 schema:datePublished 2013-07
    103 schema:datePublishedReg 2013-07-01
    104 schema:description The clinical benefits of BRAF inhibition in patients with advanced-stage BRAF-mutant melanoma are now well established. Although the emergence of cutaneous squamous-cell carcinomas (SCCs) and secondary melanomas in patients on BRAF-inhibitor therapy have been well described, reports are emerging of additional secondary premalignant and malignant events, including RAS-mutant leukaemia, the metastatic recurrence of RAS-mutant colorectal cancer and the development of gastric and colonic polyps. In most cases, paradoxical MAPK activation--resulting from the BRAF-inhibitor-mediated homodimerization and heterodimerization of nonmutant RAF isoforms--seems to underlie the development of these secondary tumours. Although evidence supports that therapy with the simultaneous administration of BRAF and MEK inhibitors abrogates the onset of treatment-induced SCCs, whether combination treatment will limit the emergence of all BRAF-inhibitor-driven pathologies is unclear. In this Review, we describe the clinical and mechanistic manifestations of secondary cancers that have thus far been observed to arise as a consequence of BRAF inhibition. We discuss the concept of pre-existing populations of partly transformed cells with malignant potential that might be present in various organ systems, and the rationale for novel therapeutic strategies for the management of BRAF-inhibitor-induced neoplasia.
    105 schema:genre research_article
    106 schema:inLanguage en
    107 schema:isAccessibleForFree true
    108 schema:isPartOf N571cf05360d74651bb15e5f3f3f7e879
    109 N8118b7983752402482b8e312da3bb4ae
    110 sg:journal.1034153
    111 schema:name Paradoxical oncogenesis—the long-term effects of BRAF inhibition in melanoma
    112 schema:pagination 390
    113 schema:productId N306f57c4e0a24f6f9e2ff883c2bde8df
    114 Nab2f1599591646f2b1faabb2e8429bfe
    115 Nde1290edae2d418a92cc54ad812e6419
    116 Neb2029ce4942410cb845c8c509c7486b
    117 Nf6f1b85c762a4009b81a36214e5af57d
    118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024794345
    119 https://doi.org/10.1038/nrclinonc.2013.83
    120 schema:sdDatePublished 2019-04-10T22:20
    121 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    122 schema:sdPublisher Nb5994b537ff34474a54b09e09290bf3a
    123 schema:url https://www.nature.com/articles/nrclinonc.2013.83
    124 sgo:license sg:explorer/license/
    125 sgo:sdDataset articles
    126 rdf:type schema:ScholarlyArticle
    127 N1f5f64005ea44e21a31729f1c71527e6 rdf:first sg:person.01274732656.46
    128 rdf:rest Na23e509a79104c0e8e33a750d8d5a42c
    129 N2619c2d8a23c4ec4975c8aaaf4a9d7f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Humans
    131 rdf:type schema:DefinedTerm
    132 N306f57c4e0a24f6f9e2ff883c2bde8df schema:name dimensions_id
    133 schema:value pub.1024794345
    134 rdf:type schema:PropertyValue
    135 N3da1bc17461e49359ce0be7278dbca40 rdf:first sg:person.01104010437.49
    136 rdf:rest N1f5f64005ea44e21a31729f1c71527e6
    137 N4510f2a595584632b8c5bdd919d60c0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Prognosis
    139 rdf:type schema:DefinedTerm
    140 N571cf05360d74651bb15e5f3f3f7e879 schema:issueNumber 7
    141 rdf:type schema:PublicationIssue
    142 N6736a6cde7054d33a78115c39b3e577a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Proto-Oncogene Proteins B-raf
    144 rdf:type schema:DefinedTerm
    145 N6bab0d864390475a92e5a5e793fb7eb3 rdf:first sg:person.07642674137.95
    146 rdf:rest rdf:nil
    147 N8118b7983752402482b8e312da3bb4ae schema:volumeNumber 10
    148 rdf:type schema:PublicationVolume
    149 N97b956b671764049a5e496db3a982cf3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Cell Transformation, Neoplastic
    151 rdf:type schema:DefinedTerm
    152 Na23e509a79104c0e8e33a750d8d5a42c rdf:first sg:person.0725307737.77
    153 rdf:rest N6bab0d864390475a92e5a5e793fb7eb3
    154 Nab2f1599591646f2b1faabb2e8429bfe schema:name pubmed_id
    155 schema:value 23712190
    156 rdf:type schema:PropertyValue
    157 Nb5994b537ff34474a54b09e09290bf3a schema:name Springer Nature - SN SciGraph project
    158 rdf:type schema:Organization
    159 Nde1290edae2d418a92cc54ad812e6419 schema:name doi
    160 schema:value 10.1038/nrclinonc.2013.83
    161 rdf:type schema:PropertyValue
    162 Ne6f60d6fea3f422695de05ad0f89aa11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Melanoma
    164 rdf:type schema:DefinedTerm
    165 Neb2029ce4942410cb845c8c509c7486b schema:name readcube_id
    166 schema:value 761ed9b780f05b56ff681525e04111c04496a083440b8e4944ada835a47113fa
    167 rdf:type schema:PropertyValue
    168 Neb2ebe0da84f43019a5285d5f209d4e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Antineoplastic Agents
    170 rdf:type schema:DefinedTerm
    171 Nee818b87c0774fe2ac45bc584a5a973a rdf:first sg:person.01065153434.51
    172 rdf:rest N3da1bc17461e49359ce0be7278dbca40
    173 Nf6f1b85c762a4009b81a36214e5af57d schema:name nlm_unique_id
    174 schema:value 101500077
    175 rdf:type schema:PropertyValue
    176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    177 schema:name Medical and Health Sciences
    178 rdf:type schema:DefinedTerm
    179 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    180 schema:name Oncology and Carcinogenesis
    181 rdf:type schema:DefinedTerm
    182 sg:grant.2481570 http://pending.schema.org/fundedItem sg:pub.10.1038/nrclinonc.2013.83
    183 rdf:type schema:MonetaryGrant
    184 sg:grant.2699085 http://pending.schema.org/fundedItem sg:pub.10.1038/nrclinonc.2013.83
    185 rdf:type schema:MonetaryGrant
    186 sg:journal.1034153 schema:issn 1759-4774
    187 1759-4782
    188 schema:name Nature Reviews Clinical Oncology
    189 rdf:type schema:Periodical
    190 sg:person.01065153434.51 schema:affiliation https://www.grid.ac/institutes/grid.468198.a
    191 schema:familyName Gibney
    192 schema:givenName Geoffrey T.
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065153434.51
    194 rdf:type schema:Person
    195 sg:person.01104010437.49 schema:affiliation https://www.grid.ac/institutes/grid.170693.a
    196 schema:familyName Messina
    197 schema:givenName Jane L.
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104010437.49
    199 rdf:type schema:Person
    200 sg:person.01274732656.46 schema:affiliation https://www.grid.ac/institutes/grid.468198.a
    201 schema:familyName Fedorenko
    202 schema:givenName Inna V.
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274732656.46
    204 rdf:type schema:Person
    205 sg:person.0725307737.77 schema:affiliation https://www.grid.ac/institutes/grid.468198.a
    206 schema:familyName Sondak
    207 schema:givenName Vernon K.
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725307737.77
    209 rdf:type schema:Person
    210 sg:person.07642674137.95 schema:affiliation https://www.grid.ac/institutes/grid.468198.a
    211 schema:familyName Smalley
    212 schema:givenName Keiran S. M.
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07642674137.95
    214 rdf:type schema:Person
    215 sg:pub.10.1007/s11894-011-0218-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037027357
    216 https://doi.org/10.1007/s11894-011-0218-4
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/383181a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044422710
    219 https://doi.org/10.1038/383181a0
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/ajg.2009.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016038883
    222 https://doi.org/10.1038/ajg.2009.139
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/nature00766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023536940
    225 https://doi.org/10.1038/nature00766
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/nature04304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012130507
    228 https://doi.org/10.1038/nature04304
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/nature08833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009288742
    231 https://doi.org/10.1038/nature08833
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nature08902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006916541
    234 https://doi.org/10.1038/nature08902
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nature09454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032620847
    237 https://doi.org/10.1038/nature09454
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/nature09626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035733152
    240 https://doi.org/10.1038/nature09626
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nature10662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028208693
    243 https://doi.org/10.1038/nature10662
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nature10868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038374700
    246 https://doi.org/10.1038/nature10868
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/ncomms1727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011476380
    249 https://doi.org/10.1038/ncomms1727
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/nm.2143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032797854
    252 https://doi.org/10.1038/nm.2143
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/nrc1097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044819609
    255 https://doi.org/10.1038/nrc1097
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/nrclinonc.2011.192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009594521
    258 https://doi.org/10.1038/nrclinonc.2011.192
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/nrclinonc.2012.215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000243646
    261 https://doi.org/10.1038/nrclinonc.2012.215
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/nrd2397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018115916
    264 https://doi.org/10.1038/nrd2397
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/nrgastro.2009.70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023847041
    267 https://doi.org/10.1038/nrgastro.2009.70
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/nrm1498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050758604
    270 https://doi.org/10.1038/nrm1498
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/onc.2010.408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011149116
    273 https://doi.org/10.1038/onc.2010.408
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/sj.bjc.6605714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013296980
    276 https://doi.org/10.1038/sj.bjc.6605714
    277 rdf:type schema:CreativeWork
    278 https://app.dimensions.ai/details/publication/pub.1075262313 schema:CreativeWork
    279 https://doi.org/10.1002/1097-0142(19850801)56:3<531::aid-cncr2820560321>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033058269
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.bcp.2011.05.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013269526
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.ccr.2010.10.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052124278
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.ccr.2012.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053006533
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.cell.2009.12.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028106155
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.cgh.2009.05.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043630703
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/j.cub.2012.03.067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008408030
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.jaad.2008.06.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011791387
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.molcel.2005.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020789267
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.molcel.2005.10.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037007117
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.molonc.2013.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049679003
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/s0002-9440(10)62511-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032648731
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/s0092-8674(00)00122-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053728752
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/s0092-8674(00)81333-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014745301
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/s0092-8674(04)00215-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019563286
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/s0140-6736(12)60398-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015389206
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/s0140-6736(12)60868-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003772891
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/s0959-8049(97)10111-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001133027
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/s1011-1344(01)00206-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042146010
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/s1470-2045(12)70413-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006760591
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/s1470-2045(13)70024-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051396936
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1039/c2mb25393c schema:sameAs https://app.dimensions.ai/details/publication/pub.1018701259
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1053/j.seminoncol.2012.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037837573
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1056/nejmc0904160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033520688
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1056/nejmc1108651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029020155
    328 https://app.dimensions.ai/details/publication/pub.1078462624
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1056/nejmoa1002011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012824919
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1056/nejmoa1014209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044873328
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1056/nejmoa1103782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041864150
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1056/nejmoa1105358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006141094
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1056/nejmoa1203421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051983710
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1056/nejmoa1208958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022455909
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1056/nejmoa1210093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036427533
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1073/pnas.0711741105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053628579
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1073/pnas.1008990107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039016844
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1074/jbc.m802855200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031343092
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1093/carcin/20.10.1939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047999324
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1093/carcin/bgg009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029084752
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1093/carcin/bgs349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047682503
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1093/emboj/16.13.3797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012071604
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1093/emboj/17.5.1371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041267201
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1093/jnci/djq442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049373746
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1111/j.1365-2133.2012.11155.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033639771
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1111/j.1464-410x.2008.07900.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044116307
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1111/j.1755-148x.2008.00491.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037715578
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1111/j.1755-148x.2010.00685.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017083437
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1111/j.1755-148x.2012.00981.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004899602
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1111/pcmr.12092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018424257
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1128/mcb.26.6.2262-2272.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009784412
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1158/0008-5472.can-03-3433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007018612
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1158/0008-5472.can-08-3201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035602391
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1158/0008-5472.can-09-4471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027786788
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1158/0008-5472.can-11-3747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011377387
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1158/1078-0432.ccr-07-1440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048145384
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1158/1078-0432.ccr-11-1491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009764558
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1158/1535-7163.mct-11-0989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050113307
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1158/1940-6207.capr-08-0206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004457633
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1158/2159-8290.cd-11-0341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043663281
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1172/jci65780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016683402
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1200/jco.2010.32.4327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027360666
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1200/jco.2010.33.2312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040298667
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1200/jco.2011.36.7680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016636989
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1200/jco.2011.39.8594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009260124
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1200/jco.2011.41.1660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000408054
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1200/jco.2012.30.18_suppl.lba8509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083397228
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1371/journal.pone.0058721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005168367
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1562/0031-8655(2002)0760073ceimah2.0.co2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049929859
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1562/0031-8655(2002)076<0073:ceimah>2.0.co;2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068006923
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1634/theoncologist.2012-0333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023646847
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.2147/dddt.s38998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045937080
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.3322/caac.21166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021817259
    419 rdf:type schema:CreativeWork
    420 https://www.grid.ac/institutes/grid.170693.a schema:alternateName University of South Florida
    421 schema:name Department of Pathology and Cell Biology, University of South Florida College of Medicine, 12901 Bruce B. Downs Boulevard, MDC 11, Tampa, FL 33612, USA
    422 rdf:type schema:Organization
    423 https://www.grid.ac/institutes/grid.468198.a schema:alternateName Moffitt Cancer Center
    424 schema:name Department of Cutaneous Oncology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    425 Department of Molecular Oncology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    426 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...