Making the best of PARP inhibitors in ovarian cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-09

AUTHORS

Susana Banerjee, Stan B. Kaye, Alan Ashworth

ABSTRACT

Drugs that inhibit the enzyme poly(ADP-ribose)polymerase (PARP) are showing considerable promise for the treatment of cancers that have mutations in the BRCA1 or BRCA2 tumor suppressors. This therapeutic approach exploits a synthetic lethal strategy to target the specific DNA repair pathway in these tumors. High-grade ovarian cancers have a generally poor prognosis, and accumulating evidence suggests that mutations in BRCA1 or BRCA2, or silencing of BRCA1 by promoter methylation, may be common in this disease. Here, we consider how the potential benefit of PARP inhibitors might be maximized in ovarian cancer. We suggest that it will be crucial to explore novel therapeutic trial strategies and drug combinations, and incorporate robust biomarkers predictive of response if these drugs are to reach their full potential. More... »

PAGES

508

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrclinonc.2010.116

DOI

http://dx.doi.org/10.1038/nrclinonc.2010.116

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022428089

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20700108


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