Epidemiology and pathophysiology of Takotsubo syndrome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-04-07

AUTHORS

Yoshihiro J. Akashi, Holger M. Nef, Alexander R. Lyon

ABSTRACT

Key PointsApproximately 2% of patients who present to hospital with suspected acute coronary syndrome have Takotsubo syndrome, with a predominance in postmenopausal womenMortality is higher than initially thought, and recurrence is seen in 1.2% of patients within 6 months and nearly 5% at 6 years, with no preventive therapy currently availableSystemic catecholamine surges can cause acute coronary and peripheral vasospasm followed by peripheral vasodilation; a common complication is cardiogenic shock, due at least in part to left ventricular systolic dysfunctionBiopsy samples taken during the acute phase of Takotsubo syndrome show morphological changes similar to those after catecholamine-induced cardiotoxic effects, supporting direct effects as well as vascular influencesThe apical myocardium of the left ventricle has a high density of β-adrenoceptors and, therefore, is the region most sensitive to circulating catecholaminesDuring extreme stress, excessive epinephrine levels cause a switch from the Gsα stimulatory to the cardioprotective Giα cardioinhibitory secondary messenger pathway within cardiomyocytes, thereby acting as a positive inotrope More... »

PAGES

387-397

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrcardio.2015.39

DOI

http://dx.doi.org/10.1038/nrcardio.2015.39

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042647109

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25855605


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195 grid-institutes:grid.451056.3 schema:alternateName NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital and Imperial College, Sydney Street, SW3 6NP, London, UK
196 schema:name NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital and Imperial College, Sydney Street, SW3 6NP, London, UK
197 rdf:type schema:Organization
 




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