Metabolomics as a tool for cardiac research View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-11

AUTHORS

Julian L. Griffin, Helen Atherton, John Shockcor, Luigi Atzori

ABSTRACT

Metabolomics represents a paradigm shift in metabolic research, away from approaches that focus on a limited number of enzymatic reactions or single pathways, to approaches that attempt to capture the complexity of metabolic networks. Additionally, the high-throughput nature of metabolomics makes it ideal to perform biomarker screens for diseases or follow drug efficacy. In this Review, we explore the role of metabolomics in gaining mechanistic insight into cardiac disease processes, and in the search for novel biomarkers. High-resolution NMR spectroscopy and mass spectrometry are both highly discriminatory for a range of pathological processes affecting the heart, including cardiac ischemia, myocardial infarction, and heart failure. We also discuss the position of metabolomics in the range of functional-genomic approaches, being complementary to proteomic and transcriptomic studies, and having subdivisions such as lipidomics (the study of intact lipid species). In addition to techniques that monitor changes in the total sizes of pools of metabolites in the heart and biofluids, the role of stable-isotope methods for monitoring fluxes through pathways is examined. The use of these novel functional-genomic tools to study metabolism provides a unique insight into cardiac disease progression. More... »

PAGES

630

References to SciGraph publications

  • 2009-12. Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor δ from Peroxisome proliferator-activated receptor γ in the ob/obmouse in GENOME MEDICINE
  • 2010-07. Metabolomics and Atherosclerosis in CURRENT ATHEROSCLEROSIS REPORTS
  • 2009-12. Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease in DIABETOLOGIA
  • 2008-04. Compensated cardiac hypertrophy is characterised by a decline in palmitate oxidation in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2007-06. Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster mice in METABOLOMICS
  • 2005-07. The emerging field of lipidomics in NATURE REVIEWS DRUG DISCOVERY
  • 2011-04. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease in NATURE
  • 2007-02. Innovations: Towards the plant metabolome and beyond in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2007-04. NMR-based prediction of cardiovascular risk in diabetes in NATURE MEDICINE
  • 2000-11. Metabolite profiling for plant functional genomics in NATURE BIOTECHNOLOGY
  • 2006-06. Proton NMR analysis of plasma is a weak predictor of coronary artery disease in NATURE MEDICINE
  • 2007-09. Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis in GENOME BIOLOGY
  • 2009-03. Applications of metabolomics and proteomics to the mdx mouse model of Duchenne muscular dystrophy: lessons from downstream of the transcriptome in GENOME MEDICINE
  • 2007-12. Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate in METABOLOMICS
  • 2002-12. Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics in NATURE MEDICINE
  • 2008-05-15. Human metabolic phenotype diversity and its association with diet and blood pressure in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrcardio.2011.138

    DOI

    http://dx.doi.org/10.1038/nrcardio.2011.138

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003180459

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21931361


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0301", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Analytical Chemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Chemical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomedical Technology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cardiovascular Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Magnetic Resonance Spectroscopy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mass Spectrometry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Metabolic Networks and Pathways", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "MRC Human Nutrition Research", 
              "id": "https://www.grid.ac/institutes/grid.415055.0", 
              "name": [
                "MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Griffin", 
            "givenName": "Julian L.", 
            "id": "sg:person.012451221647.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012451221647.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Cambridge", 
              "id": "https://www.grid.ac/institutes/grid.5335.0", 
              "name": [
                "The Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Atherton", 
            "givenName": "Helen", 
            "id": "sg:person.0772752667.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772752667.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Cambridge", 
              "id": "https://www.grid.ac/institutes/grid.5335.0", 
              "name": [
                "The Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shockcor", 
            "givenName": "John", 
            "id": "sg:person.01171033712.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171033712.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Cagliari", 
              "id": "https://www.grid.ac/institutes/grid.7763.5", 
              "name": [
                "Department of Toxicology, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Atzori", 
            "givenName": "Luigi", 
            "id": "sg:person.01030303121.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030303121.12"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1136/bmj.321.7258.405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000154862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bms.1200100804", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002093296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bms.1200100804", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002093296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11306-007-0052-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002778180", 
              "https://doi.org/10.1007/s11306-007-0052-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002778922", 
              "https://doi.org/10.1038/nature06882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj1960171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003480833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj1960171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003480833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0185(199810)252:2<311::aid-ar17>3.0.co;2-q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003942652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mrm.1185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005327534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mrm.21760", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005585295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/msb.2009.18", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005612563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/msb.2009.18", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005612563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpendo.00139.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007215645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpendo.00139.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007215645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(02)03437-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008354542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0167-7799(98)01214-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008971544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.105.569137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009007853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db09-1114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009324659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rstb.2005.1734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009358099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0407-399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009367543", 
              "https://doi.org/10.1038/nm0407-399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0407-399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009367543", 
              "https://doi.org/10.1038/nm0407-399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/b209155k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010825719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0735-1097(89)90620-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011096594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000183928.25844.f6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011221761"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000183928.25844.f6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011221761"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-5793(81)80317-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011737588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physiolgenomics.00188.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011821649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1194/jlr.m200169-jlr200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011946118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physiolgenomics.00060.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012941932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.73.12.4446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013760554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1099-1492(199802)11:1<1::aid-nbm493>3.0.co;2-d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013768398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1099-1492(199802)11:1<1::aid-nbm493>3.0.co;2-d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013768398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yjmcc.2008.10.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014125259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.80.6.1603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014377875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.15.6.3012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015795133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.59.3.270", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016407690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yjmcc.2007.05.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016654940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0378-4347(00)80350-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018459059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gm115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018637802", 
              "https://doi.org/10.1186/gm115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.81.8.2517", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019300010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000039326.87475.98", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019335082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/b902356a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019514002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/b902356a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019514002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci35111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020452485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/b906712b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021976002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/004982599238047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022006804"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/msb.2010.93", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024888424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/msb.2010.93", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024888424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.atherosclerosis.2009.01.040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025782358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gm32", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026356851", 
              "https://doi.org/10.1186/gm32"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0002-9149(74)90089-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027274680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj2100477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027612717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj2100477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027612717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-291x(88)80361-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030101760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1202-802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030228780", 
              "https://doi.org/10.1038/nm1202-802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1202-802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030228780", 
              "https://doi.org/10.1038/nm1202-802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0000218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031377795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1194/jlr.d500007-jlr200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032756436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032924365", 
              "https://doi.org/10.1038/nrm2098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034214135", 
              "https://doi.org/10.1038/nm1432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034214135", 
              "https://doi.org/10.1038/nm1432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.108.178459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034230924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.108.178459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034230924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mas.20023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034989432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/msb4100205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035030623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/msb4100205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035030623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/abio.2001.5096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035332704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.106.645614", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035642660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/nbm.1352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035709171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-009-1482-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036177566", 
              "https://doi.org/10.1007/s00125-009-1482-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-009-1482-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036177566", 
              "https://doi.org/10.1007/s00125-009-1482-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-009-1482-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036177566", 
              "https://doi.org/10.1007/s00125-009-1482-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036491584", 
              "https://doi.org/10.1038/nrd1776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036491584", 
              "https://doi.org/10.1038/nrd1776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkn810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036882549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2007-8-9-r200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036984188", 
              "https://doi.org/10.1186/gb-2007-8-9-r200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c0mb00066c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037134682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yjmcc.2005.09.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037463576"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0000097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037950478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibtech.2004.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037967197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkl923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038368215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0378-4347(00)81425-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039358884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041945577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0706235104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042495036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yjmcc.2007.11.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042596302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.01340.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043010904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043309820", 
              "https://doi.org/10.1038/nature09922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.106.668665", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043676409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11306-007-0063-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043894656", 
              "https://doi.org/10.1007/s11306-007-0063-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/81137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045090002", 
              "https://doi.org/10.1038/81137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/81137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045090002", 
              "https://doi.org/10.1038/81137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/14622416.8.9.1243", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045500553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yjmcc.2009.08.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046142750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hypertensionaha.109.145490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046632102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hypertensionaha.109.145490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046632102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11883-010-0112-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046861120", 
              "https://doi.org/10.1007/s11883-010-0112-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11883-010-0112-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046861120", 
              "https://doi.org/10.1007/s11883-010-0112-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddl433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047093599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chroma.2005.05.088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047449606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.09-129171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048271682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circimaging.110.959098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048795351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circimaging.110.959098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048795351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1469-185x.2010.00157.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048811782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/nbm.1370", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051047342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/nbm.1370", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051047342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.106.613646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051091164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/pr900668v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051692163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11010-008-9711-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052000146", 
              "https://doi.org/10.1007/s11010-008-9711-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbalip.2009.11.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052205967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.110.218966", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052312947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.110.218966", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052312947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rstb.1980.0059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052689896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2362.2010.02441.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053706064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0008-6363(99)00056-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054580361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00583a032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055181652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi047773a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055198722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi047773a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055198722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi051908a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055201198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi051908a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055201198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/pr800070p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056294297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/153623104773547453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059215077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cvr/22.11.833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059486737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2675315", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062549952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.91.7.2071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063336199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.81.2.165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063341112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.2000.279.6.c1704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074728257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077347889", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.1990.258.5.h1357", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078683950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079422232", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080070461", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpendo.1995.268.6.e1070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082434222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083320189", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-11", 
        "datePublishedReg": "2011-11-01", 
        "description": "Metabolomics represents a paradigm shift in metabolic research, away from approaches that focus on a limited number of enzymatic reactions or single pathways, to approaches that attempt to capture the complexity of metabolic networks. Additionally, the high-throughput nature of metabolomics makes it ideal to perform biomarker screens for diseases or follow drug efficacy. In this Review, we explore the role of metabolomics in gaining mechanistic insight into cardiac disease processes, and in the search for novel biomarkers. High-resolution NMR spectroscopy and mass spectrometry are both highly discriminatory for a range of pathological processes affecting the heart, including cardiac ischemia, myocardial infarction, and heart failure. We also discuss the position of metabolomics in the range of functional-genomic approaches, being complementary to proteomic and transcriptomic studies, and having subdivisions such as lipidomics (the study of intact lipid species). In addition to techniques that monitor changes in the total sizes of pools of metabolites in the heart and biofluids, the role of stable-isotope methods for monitoring fluxes through pathways is examined. The use of these novel functional-genomic tools to study metabolism provides a unique insight into cardiac disease progression.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nrcardio.2011.138", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2782025", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2785012", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2776915", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1345537", 
            "issn": [
              "1423-5528", 
              "1662-629X"
            ], 
            "name": "Nature Reviews Cardiology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "11", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "name": "Metabolomics as a tool for cardiac research", 
        "pagination": "630", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "0f26548a739179a2f8d2b55c349a83bf25b5b209db9e8d69176cd754d06133b6"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21931361"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101500075"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrcardio.2011.138"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1003180459"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrcardio.2011.138", 
          "https://app.dimensions.ai/details/publication/pub.1003180459"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000435.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nrcardio.2011.138"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrcardio.2011.138'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrcardio.2011.138'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrcardio.2011.138'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrcardio.2011.138'


     

    This table displays all metadata directly associated to this object as RDF triples.

    463 TRIPLES      21 PREDICATES      143 URIs      28 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrcardio.2011.138 schema:about N1df5cfe7752b4a11bffdeab0218dcacf
    2 N38ba6f36921b49268129294f16680c93
    3 N7efcee30bcaf4fb090bd84859598de95
    4 Na59f615517724114b157502ae15f087d
    5 Nd2c9c216ba674d24a214c2119a66afa1
    6 Nf35eb3a5017245a297827607a373c2e0
    7 Nf369c20f3ebe4b5691089897d467999e
    8 anzsrc-for:03
    9 anzsrc-for:0301
    10 schema:author Ned1844f14d2a4ccca31bc99a9e66ca84
    11 schema:citation sg:pub.10.1007/s00125-009-1482-9
    12 sg:pub.10.1007/s11010-008-9711-y
    13 sg:pub.10.1007/s11306-007-0052-8
    14 sg:pub.10.1007/s11306-007-0063-5
    15 sg:pub.10.1007/s11883-010-0112-9
    16 sg:pub.10.1038/81137
    17 sg:pub.10.1038/nature06882
    18 sg:pub.10.1038/nature09922
    19 sg:pub.10.1038/nm0407-399
    20 sg:pub.10.1038/nm1202-802
    21 sg:pub.10.1038/nm1432
    22 sg:pub.10.1038/nrd1776
    23 sg:pub.10.1038/nrm2098
    24 sg:pub.10.1186/gb-2007-8-9-r200
    25 sg:pub.10.1186/gm115
    26 sg:pub.10.1186/gm32
    27 https://app.dimensions.ai/details/publication/pub.1077347889
    28 https://app.dimensions.ai/details/publication/pub.1079422232
    29 https://app.dimensions.ai/details/publication/pub.1080070461
    30 https://app.dimensions.ai/details/publication/pub.1083320189
    31 https://doi.org/10.1002/(sici)1097-0185(199810)252:2<311::aid-ar17>3.0.co;2-q
    32 https://doi.org/10.1002/(sici)1099-1492(199802)11:1<1::aid-nbm493>3.0.co;2-d
    33 https://doi.org/10.1002/bms.1200100804
    34 https://doi.org/10.1002/mas.20023
    35 https://doi.org/10.1002/mrm.1185
    36 https://doi.org/10.1002/mrm.21760
    37 https://doi.org/10.1002/nbm.1352
    38 https://doi.org/10.1002/nbm.1370
    39 https://doi.org/10.1006/abio.2001.5096
    40 https://doi.org/10.1016/0002-9149(74)90089-7
    41 https://doi.org/10.1016/0014-5793(81)80317-1
    42 https://doi.org/10.1016/0735-1097(89)90620-7
    43 https://doi.org/10.1016/j.atherosclerosis.2009.01.040
    44 https://doi.org/10.1016/j.bbalip.2009.11.004
    45 https://doi.org/10.1016/j.chroma.2005.05.088
    46 https://doi.org/10.1016/j.tibtech.2004.03.007
    47 https://doi.org/10.1016/j.yjmcc.2005.09.018
    48 https://doi.org/10.1016/j.yjmcc.2007.05.015
    49 https://doi.org/10.1016/j.yjmcc.2007.11.006
    50 https://doi.org/10.1016/j.yjmcc.2008.10.008
    51 https://doi.org/10.1016/j.yjmcc.2009.08.017
    52 https://doi.org/10.1016/s0006-291x(88)80361-9
    53 https://doi.org/10.1016/s0008-6363(99)00056-5
    54 https://doi.org/10.1016/s0014-5793(02)03437-3
    55 https://doi.org/10.1016/s0167-7799(98)01214-1
    56 https://doi.org/10.1016/s0378-4347(00)80350-3
    57 https://doi.org/10.1016/s0378-4347(00)81425-5
    58 https://doi.org/10.1021/bi00583a032
    59 https://doi.org/10.1021/bi047773a
    60 https://doi.org/10.1021/bi051908a
    61 https://doi.org/10.1021/pr800070p
    62 https://doi.org/10.1021/pr900668v
    63 https://doi.org/10.1038/msb.2009.18
    64 https://doi.org/10.1038/msb.2010.93
    65 https://doi.org/10.1038/msb4100205
    66 https://doi.org/10.1039/b209155k
    67 https://doi.org/10.1039/b902356a
    68 https://doi.org/10.1039/b906712b
    69 https://doi.org/10.1039/c0mb00066c
    70 https://doi.org/10.1042/bj1960171
    71 https://doi.org/10.1042/bj2100477
    72 https://doi.org/10.1073/pnas.0706235104
    73 https://doi.org/10.1073/pnas.73.12.4446
    74 https://doi.org/10.1073/pnas.80.6.1603
    75 https://doi.org/10.1073/pnas.81.8.2517
    76 https://doi.org/10.1080/004982599238047
    77 https://doi.org/10.1089/153623104773547453
    78 https://doi.org/10.1093/cvr/22.11.833
    79 https://doi.org/10.1093/hmg/ddl433
    80 https://doi.org/10.1093/nar/gkl923
    81 https://doi.org/10.1093/nar/gkn810
    82 https://doi.org/10.1096/fj.09-129171
    83 https://doi.org/10.1098/rstb.1980.0059
    84 https://doi.org/10.1098/rstb.2005.1734
    85 https://doi.org/10.1111/j.1365-2362.2010.02441.x
    86 https://doi.org/10.1111/j.1469-185x.2010.00157.x
    87 https://doi.org/10.1126/science.2675315
    88 https://doi.org/10.1128/mcb.15.6.3012
    89 https://doi.org/10.1136/bmj.321.7258.405
    90 https://doi.org/10.1152/ajpcell.2000.279.6.c1704
    91 https://doi.org/10.1152/ajpendo.00139.2005
    92 https://doi.org/10.1152/ajpendo.1995.268.6.e1070
    93 https://doi.org/10.1152/ajpheart.01340.2007
    94 https://doi.org/10.1152/ajpheart.1990.258.5.h1357
    95 https://doi.org/10.1152/physiolgenomics.00060.2006
    96 https://doi.org/10.1152/physiolgenomics.00188.2009
    97 https://doi.org/10.1161/01.atv.0000183928.25844.f6
    98 https://doi.org/10.1161/01.cir.0000039326.87475.98
    99 https://doi.org/10.1161/01.cir.91.7.2071
    100 https://doi.org/10.1161/01.res.59.3.270
    101 https://doi.org/10.1161/01.res.81.2.165
    102 https://doi.org/10.1161/circimaging.110.959098
    103 https://doi.org/10.1161/circresaha.108.178459
    104 https://doi.org/10.1161/circresaha.110.218966
    105 https://doi.org/10.1161/circulationaha.105.569137
    106 https://doi.org/10.1161/circulationaha.106.613646
    107 https://doi.org/10.1161/circulationaha.106.645614
    108 https://doi.org/10.1161/circulationaha.106.668665
    109 https://doi.org/10.1161/hypertensionaha.109.145490
    110 https://doi.org/10.1172/jci35111
    111 https://doi.org/10.1194/jlr.d500007-jlr200
    112 https://doi.org/10.1194/jlr.m200169-jlr200
    113 https://doi.org/10.1371/journal.pgen.1000282
    114 https://doi.org/10.1371/journal.pone.0000097
    115 https://doi.org/10.1371/journal.pone.0000218
    116 https://doi.org/10.2217/14622416.8.9.1243
    117 https://doi.org/10.2337/db09-1114
    118 schema:datePublished 2011-11
    119 schema:datePublishedReg 2011-11-01
    120 schema:description Metabolomics represents a paradigm shift in metabolic research, away from approaches that focus on a limited number of enzymatic reactions or single pathways, to approaches that attempt to capture the complexity of metabolic networks. Additionally, the high-throughput nature of metabolomics makes it ideal to perform biomarker screens for diseases or follow drug efficacy. In this Review, we explore the role of metabolomics in gaining mechanistic insight into cardiac disease processes, and in the search for novel biomarkers. High-resolution NMR spectroscopy and mass spectrometry are both highly discriminatory for a range of pathological processes affecting the heart, including cardiac ischemia, myocardial infarction, and heart failure. We also discuss the position of metabolomics in the range of functional-genomic approaches, being complementary to proteomic and transcriptomic studies, and having subdivisions such as lipidomics (the study of intact lipid species). In addition to techniques that monitor changes in the total sizes of pools of metabolites in the heart and biofluids, the role of stable-isotope methods for monitoring fluxes through pathways is examined. The use of these novel functional-genomic tools to study metabolism provides a unique insight into cardiac disease progression.
    121 schema:genre research_article
    122 schema:inLanguage en
    123 schema:isAccessibleForFree false
    124 schema:isPartOf N61d6709a4d4a4541a888563fa25bee82
    125 N7b59eab3e25b4c11bbf0348eb7f3b550
    126 sg:journal.1345537
    127 schema:name Metabolomics as a tool for cardiac research
    128 schema:pagination 630
    129 schema:productId N25431c5269384fe582ff900aa4f8c9af
    130 N8cd63f98861f4dbe8bf77079b0af0405
    131 Na17f902674a743e8a40d703039a60892
    132 Nc651e402ace64422869a1b6d9b4da596
    133 Neb10211f5d9a4a85814b5daccfbb31c0
    134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003180459
    135 https://doi.org/10.1038/nrcardio.2011.138
    136 schema:sdDatePublished 2019-04-10T16:30
    137 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    138 schema:sdPublisher Nc8a5c4e99e524590b7299f4c784e530e
    139 schema:url https://www.nature.com/articles/nrcardio.2011.138
    140 sgo:license sg:explorer/license/
    141 sgo:sdDataset articles
    142 rdf:type schema:ScholarlyArticle
    143 N1df5cfe7752b4a11bffdeab0218dcacf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Metabolic Networks and Pathways
    145 rdf:type schema:DefinedTerm
    146 N243ca3554818475592d19cd0382ae378 rdf:first sg:person.01171033712.18
    147 rdf:rest N7ef13256e11c4c23af847cfc0c67fe4c
    148 N25431c5269384fe582ff900aa4f8c9af schema:name pubmed_id
    149 schema:value 21931361
    150 rdf:type schema:PropertyValue
    151 N38ba6f36921b49268129294f16680c93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Biomedical Technology
    153 rdf:type schema:DefinedTerm
    154 N3c1269e748464deaa2b4af579c9d2e7e rdf:first sg:person.0772752667.42
    155 rdf:rest N243ca3554818475592d19cd0382ae378
    156 N61d6709a4d4a4541a888563fa25bee82 schema:issueNumber 11
    157 rdf:type schema:PublicationIssue
    158 N7b59eab3e25b4c11bbf0348eb7f3b550 schema:volumeNumber 8
    159 rdf:type schema:PublicationVolume
    160 N7ef13256e11c4c23af847cfc0c67fe4c rdf:first sg:person.01030303121.12
    161 rdf:rest rdf:nil
    162 N7efcee30bcaf4fb090bd84859598de95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Humans
    164 rdf:type schema:DefinedTerm
    165 N8cd63f98861f4dbe8bf77079b0af0405 schema:name readcube_id
    166 schema:value 0f26548a739179a2f8d2b55c349a83bf25b5b209db9e8d69176cd754d06133b6
    167 rdf:type schema:PropertyValue
    168 Na17f902674a743e8a40d703039a60892 schema:name dimensions_id
    169 schema:value pub.1003180459
    170 rdf:type schema:PropertyValue
    171 Na59f615517724114b157502ae15f087d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Magnetic Resonance Spectroscopy
    173 rdf:type schema:DefinedTerm
    174 Nc651e402ace64422869a1b6d9b4da596 schema:name nlm_unique_id
    175 schema:value 101500075
    176 rdf:type schema:PropertyValue
    177 Nc8a5c4e99e524590b7299f4c784e530e schema:name Springer Nature - SN SciGraph project
    178 rdf:type schema:Organization
    179 Nd2c9c216ba674d24a214c2119a66afa1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Mass Spectrometry
    181 rdf:type schema:DefinedTerm
    182 Neb10211f5d9a4a85814b5daccfbb31c0 schema:name doi
    183 schema:value 10.1038/nrcardio.2011.138
    184 rdf:type schema:PropertyValue
    185 Ned1844f14d2a4ccca31bc99a9e66ca84 rdf:first sg:person.012451221647.25
    186 rdf:rest N3c1269e748464deaa2b4af579c9d2e7e
    187 Nf35eb3a5017245a297827607a373c2e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Cardiovascular Diseases
    189 rdf:type schema:DefinedTerm
    190 Nf369c20f3ebe4b5691089897d467999e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Biomarkers
    192 rdf:type schema:DefinedTerm
    193 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
    194 schema:name Chemical Sciences
    195 rdf:type schema:DefinedTerm
    196 anzsrc-for:0301 schema:inDefinedTermSet anzsrc-for:
    197 schema:name Analytical Chemistry
    198 rdf:type schema:DefinedTerm
    199 sg:grant.2776915 http://pending.schema.org/fundedItem sg:pub.10.1038/nrcardio.2011.138
    200 rdf:type schema:MonetaryGrant
    201 sg:grant.2782025 http://pending.schema.org/fundedItem sg:pub.10.1038/nrcardio.2011.138
    202 rdf:type schema:MonetaryGrant
    203 sg:grant.2785012 http://pending.schema.org/fundedItem sg:pub.10.1038/nrcardio.2011.138
    204 rdf:type schema:MonetaryGrant
    205 sg:journal.1345537 schema:issn 1423-5528
    206 1662-629X
    207 schema:name Nature Reviews Cardiology
    208 rdf:type schema:Periodical
    209 sg:person.01030303121.12 schema:affiliation https://www.grid.ac/institutes/grid.7763.5
    210 schema:familyName Atzori
    211 schema:givenName Luigi
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030303121.12
    213 rdf:type schema:Person
    214 sg:person.01171033712.18 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
    215 schema:familyName Shockcor
    216 schema:givenName John
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171033712.18
    218 rdf:type schema:Person
    219 sg:person.012451221647.25 schema:affiliation https://www.grid.ac/institutes/grid.415055.0
    220 schema:familyName Griffin
    221 schema:givenName Julian L.
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012451221647.25
    223 rdf:type schema:Person
    224 sg:person.0772752667.42 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
    225 schema:familyName Atherton
    226 schema:givenName Helen
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772752667.42
    228 rdf:type schema:Person
    229 sg:pub.10.1007/s00125-009-1482-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036177566
    230 https://doi.org/10.1007/s00125-009-1482-9
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1007/s11010-008-9711-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1052000146
    233 https://doi.org/10.1007/s11010-008-9711-y
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1007/s11306-007-0052-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002778180
    236 https://doi.org/10.1007/s11306-007-0052-8
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1007/s11306-007-0063-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043894656
    239 https://doi.org/10.1007/s11306-007-0063-5
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1007/s11883-010-0112-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046861120
    242 https://doi.org/10.1007/s11883-010-0112-9
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/81137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045090002
    245 https://doi.org/10.1038/81137
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/nature06882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002778922
    248 https://doi.org/10.1038/nature06882
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/nature09922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043309820
    251 https://doi.org/10.1038/nature09922
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/nm0407-399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009367543
    254 https://doi.org/10.1038/nm0407-399
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/nm1202-802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030228780
    257 https://doi.org/10.1038/nm1202-802
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/nm1432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034214135
    260 https://doi.org/10.1038/nm1432
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/nrd1776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036491584
    263 https://doi.org/10.1038/nrd1776
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/nrm2098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032924365
    266 https://doi.org/10.1038/nrm2098
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1186/gb-2007-8-9-r200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036984188
    269 https://doi.org/10.1186/gb-2007-8-9-r200
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1186/gm115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018637802
    272 https://doi.org/10.1186/gm115
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1186/gm32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026356851
    275 https://doi.org/10.1186/gm32
    276 rdf:type schema:CreativeWork
    277 https://app.dimensions.ai/details/publication/pub.1077347889 schema:CreativeWork
    278 https://app.dimensions.ai/details/publication/pub.1079422232 schema:CreativeWork
    279 https://app.dimensions.ai/details/publication/pub.1080070461 schema:CreativeWork
    280 https://app.dimensions.ai/details/publication/pub.1083320189 schema:CreativeWork
    281 https://doi.org/10.1002/(sici)1097-0185(199810)252:2<311::aid-ar17>3.0.co;2-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1003942652
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1002/(sici)1099-1492(199802)11:1<1::aid-nbm493>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1013768398
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1002/bms.1200100804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002093296
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1002/mas.20023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034989432
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1002/mrm.1185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005327534
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1002/mrm.21760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005585295
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1002/nbm.1352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035709171
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1002/nbm.1370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051047342
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1006/abio.2001.5096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035332704
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/0002-9149(74)90089-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027274680
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/0014-5793(81)80317-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011737588
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/0735-1097(89)90620-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011096594
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/j.atherosclerosis.2009.01.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025782358
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/j.bbalip.2009.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052205967
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/j.chroma.2005.05.088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047449606
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/j.tibtech.2004.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037967197
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/j.yjmcc.2005.09.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037463576
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/j.yjmcc.2007.05.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016654940
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/j.yjmcc.2007.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042596302
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/j.yjmcc.2008.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014125259
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/j.yjmcc.2009.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046142750
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/s0006-291x(88)80361-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030101760
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/s0008-6363(99)00056-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054580361
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/s0014-5793(02)03437-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008354542
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/s0167-7799(98)01214-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008971544
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/s0378-4347(00)80350-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018459059
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/s0378-4347(00)81425-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039358884
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1021/bi00583a032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055181652
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1021/bi047773a schema:sameAs https://app.dimensions.ai/details/publication/pub.1055198722
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1021/bi051908a schema:sameAs https://app.dimensions.ai/details/publication/pub.1055201198
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1021/pr800070p schema:sameAs https://app.dimensions.ai/details/publication/pub.1056294297
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1021/pr900668v schema:sameAs https://app.dimensions.ai/details/publication/pub.1051692163
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1038/msb.2009.18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005612563
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1038/msb.2010.93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024888424
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1038/msb4100205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035030623
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1039/b209155k schema:sameAs https://app.dimensions.ai/details/publication/pub.1010825719
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1039/b902356a schema:sameAs https://app.dimensions.ai/details/publication/pub.1019514002
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1039/b906712b schema:sameAs https://app.dimensions.ai/details/publication/pub.1021976002
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1039/c0mb00066c schema:sameAs https://app.dimensions.ai/details/publication/pub.1037134682
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1042/bj1960171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003480833
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1042/bj2100477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027612717
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1073/pnas.0706235104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042495036
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1073/pnas.73.12.4446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013760554
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1073/pnas.80.6.1603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014377875
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1073/pnas.81.8.2517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019300010
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1080/004982599238047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022006804
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1089/153623104773547453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059215077
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1093/cvr/22.11.833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059486737
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1093/hmg/ddl433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047093599
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1093/nar/gkl923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038368215
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1093/nar/gkn810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036882549
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1096/fj.09-129171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048271682
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1098/rstb.1980.0059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052689896
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1098/rstb.2005.1734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009358099
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1111/j.1365-2362.2010.02441.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053706064
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1111/j.1469-185x.2010.00157.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048811782
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1126/science.2675315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062549952
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1128/mcb.15.6.3012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015795133
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1136/bmj.321.7258.405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000154862
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1152/ajpcell.2000.279.6.c1704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074728257
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1152/ajpendo.00139.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007215645
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1152/ajpendo.1995.268.6.e1070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082434222
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1152/ajpheart.01340.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043010904
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1152/ajpheart.1990.258.5.h1357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078683950
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1152/physiolgenomics.00060.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012941932
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1152/physiolgenomics.00188.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011821649
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1161/01.atv.0000183928.25844.f6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011221761
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1161/01.cir.0000039326.87475.98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019335082
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1161/01.cir.91.7.2071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063336199
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1161/01.res.59.3.270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016407690
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1161/01.res.81.2.165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063341112
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1161/circimaging.110.959098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048795351
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1161/circresaha.108.178459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034230924
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1161/circresaha.110.218966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052312947
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1161/circulationaha.105.569137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009007853
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1161/circulationaha.106.613646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051091164
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1161/circulationaha.106.645614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035642660
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1161/circulationaha.106.668665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043676409
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1161/hypertensionaha.109.145490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046632102
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1172/jci35111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020452485
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1194/jlr.d500007-jlr200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032756436
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1194/jlr.m200169-jlr200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011946118
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1371/journal.pgen.1000282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041945577
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1371/journal.pone.0000097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037950478
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1371/journal.pone.0000218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031377795
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.2217/14622416.8.9.1243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045500553
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.2337/db09-1114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009324659
    454 rdf:type schema:CreativeWork
    455 https://www.grid.ac/institutes/grid.415055.0 schema:alternateName MRC Human Nutrition Research
    456 schema:name MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    457 rdf:type schema:Organization
    458 https://www.grid.ac/institutes/grid.5335.0 schema:alternateName University of Cambridge
    459 schema:name The Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK
    460 rdf:type schema:Organization
    461 https://www.grid.ac/institutes/grid.7763.5 schema:alternateName University of Cagliari
    462 schema:name Department of Toxicology, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy
    463 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...