Centrosome aberrations: cause or consequence of cancer progression? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-11

AUTHORS

Erich A Nigg

ABSTRACT

Many human tumours show centrosome aberrations, indicating an underlying deregulation of centrosome structure, duplication or segregation. Centrosomes organize microtubule arrays throughout the cell cycle, thereby influencing both tissue architecture and the accuracy of chromosome segregation. But what are the origins of centrosomal abnormalities in tumours, and what impact do they have on the generation of invasive, genetically unbalanced cells during cancer progression? More... »

PAGES

815-825

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrc924

DOI

http://dx.doi.org/10.1038/nrc924

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007068023

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12415252


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