The Bcl2 family: regulators of the cellular life-or-death switch View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-09

AUTHORS

Suzanne Cory, Jerry M Adams

ABSTRACT

Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed by proteases called caspases. The Bcl2 family of intracellular proteins is the central regulator of caspase activation, and its opposing factions of anti- and pro-apoptotic members arbitrate the life-or-death decision. Apoptosis is often impaired in cancer and can limit conventional therapy. A better understanding of how the Bcl2 family controls caspase activation should result in new, more effective therapeutic approaches. More... »

PAGES

647-656

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc883

    DOI

    http://dx.doi.org/10.1038/nrc883

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008451806

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12209154


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