Epithelial–mesenchymal transitions in tumour progression View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-06

AUTHORS

Jean Paul Thiery

ABSTRACT

Key Points Epithelial–mesenchymal transition (EMT) is a highly conserved and fundamental process that governs morphogenesis in multicellular organisms. There is good evidence that EMT gives rise to the dissemination of single carcinoma cells from the sites of the primary tumours. More generally, EMT might be involved in the dedifferentiation programme that leads to malignant carcinoma. Recent research conducted in embryonic model systems and in normal and transformed cell lines has identified several signal-transduction pathways for EMT, including the activation of several receptor tyrosine kinases and transforming growth factor-β receptors. Transcriptional repressors of the E-cadherin gene are activated downstream in these pathways, leading to the loss of the epithelial phenotype. Other effectors of the EMT can modulate other adhesion systems and trigger the remodelling of the actin cytoskeleton, leading to the mesenchymal phenotype and the scattering of carcinoma cells. Potential drug targets of EMT in carcinoma are now in development: inhibitors of receptor tyrosine kinases are in Phase III clinical trials. These drugs might have a considerable impact on the long-term survival of people diagnosed with cancer. More... »

PAGES

442-454

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  • Journal

    TITLE

    Nature Reviews Cancer

    ISSUE

    6

    VOLUME

    2

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc822

    DOI

    http://dx.doi.org/10.1038/nrc822

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12189386


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    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrc822'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrc822'


     

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