Dissecting tumour pathophysiology using intravital microscopy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-04

AUTHORS

Rakesh K Jain, Lance L Munn, Dai Fukumura

ABSTRACT

For a systemically administered therapeutic agent to reach neoplastic cells, it must enter the blood circulation, cross the vessel wall, move through the extracellular matrix and avoid getting cleared by the lymphatics. In tumours, each of these barriers is abnormal, changes with space and time, and depends on host-tumour interactions. Intravital microscopy has provided unprecedented molecular, cellular, anatomical and functional insights into these barriers and has revealed new approaches to improved detection and treatment. More... »

PAGES

266-276

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  • Journal

    TITLE

    Nature Reviews Cancer

    ISSUE

    4

    VOLUME

    2

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc778

    DOI

    http://dx.doi.org/10.1038/nrc778

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017974354

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12001988


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