RHO–GTPases and cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-02

AUTHORS

Erik Sahai, Christopher J Marshall

ABSTRACT

The RAS oncogenes were identified almost 20 years ago. Since then, we have learnt that they are members of a large family of small GTPases that bind GTP and hydrolyse it to GDP. This is then exchanged for GTP and the cycle is repeated. The switching between these two states regulates a wide range of cellular processes. A branch of the RAS family--the RHO proteins--is also involved in cancer, but what is the role of these proteins and would they make good therapeutic targets? More... »

PAGES

133-142

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    http://scigraph.springernature.com/pub.10.1038/nrc725

    DOI

    http://dx.doi.org/10.1038/nrc725

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022902509

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12635176


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