Specialization of tumour vasculature View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-02-01

AUTHORS

Erkki Ruoslahti

ABSTRACT

Key Points Tumours cannot grow without a blood supply. They promote the growth of new vessels through angiogenesis; initiation of angiogenesis (the 'angiogenic switch') is an important and early event in tumour progression. Tumour blood vessels are morphologically different from normal blood vessels; they are tortuous, leaky and surrounded by too few (or abnormal) pericytes. Tumour blood vessels carry distinct molecular markers in the endothelium, pericytes and in the extracellular matrix. Many of these markers are shared by angiogenic vessels in non-malignant conditions. Tumour lymphatics are an important conduit of metastasis. The use of new lymphatic vessel markers has revealed the presence of lymphatic vessels within some, but not all, tumours. Tumour cells themselves might form vessel-like channels within the tumour. These channels are lined by an extracellular matrix, rather than cells; their role as part of the tumour's circulatory system is unclear. The specialization of tumour vessels makes it possible to target diagnostic and therapeutic agents into tumours and provides new targets for drug discovery. More... »

PAGES

83-90

Journal

TITLE

Nature Reviews Cancer

ISSUE

2

VOLUME

2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrc724

DOI

http://dx.doi.org/10.1038/nrc724

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022623295

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12635171


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