The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-07

AUTHORS

Holly E. Barker, James T. E. Paget, Aadil A. Khan, Kevin J. Harrington

ABSTRACT

Radiotherapy plays a central part in curing cancer. For decades, most research on improving treatment outcomes has focused on modulating radiation-induced biological effects on cancer cells. Recently, we have better understood that components within the tumour microenvironment have pivotal roles in determining treatment outcomes. In this Review, we describe vascular, stromal and immunological changes that are induced in the tumour microenvironment by irradiation and discuss how these changes may promote radioresistance and tumour recurrence. We also highlight how this knowledge is guiding the development of new treatment paradigms in which biologically targeted agents will be combined with radiotherapy. More... »

PAGES

409-425

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrc3958

DOI

http://dx.doi.org/10.1038/nrc3958

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034104290

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26105538


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