Translational biology of osteosarcoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-11

AUTHORS

Maya Kansara, Michele W. Teng, Mark J. Smyth, David M. Thomas

ABSTRACT

For the past 30 years, improvements in the survival of patients with osteosarcoma have been mostly incremental. Despite evidence of genomic instability and a high frequency of chromothripsis and kataegis, osteosarcomas carry few recurrent targetable mutations, and trials of targeted agents have been generally disappointing. Bone has a highly specialized immune environment and many immune signalling pathways are important in bone homeostasis. The success of the innate immune stimulant mifamurtide in the adjuvant treatment of non-metastatic osteosarcoma suggests that newer immune-based treatments, such as immune checkpoint inhibitors, may substantially improve disease outcome. More... »

PAGES

722-735

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrc3838

DOI

http://dx.doi.org/10.1038/nrc3838

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032448549

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25319867


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