Developments in preclinical cancer imaging: innovating the discovery of therapeutics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-05

AUTHORS

James R. W. Conway, Neil O. Carragher, Paul Timpson

ABSTRACT

Integrating biological imaging into early stages of the drug discovery process can provide invaluable readouts of drug activity within complex disease settings, such as cancer. Iterating this approach from initial lead compound identification in vitro to proof-of-principle in vivo analysis represents a key challenge in the drug discovery field. By embracing more complex and informative models in drug discovery, imaging can improve the fidelity and statistical robustness of preclinical cancer studies. In this Review, we highlight how combining advanced imaging with three-dimensional systems and intravital mouse models can provide more informative and disease-relevant platforms for cancer drug discovery. More... »

PAGES

314-328

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc3724

    DOI

    http://dx.doi.org/10.1038/nrc3724

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036057508

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24739578


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