The ID proteins: master regulators of cancer stem cells and tumour aggressiveness View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-02

AUTHORS

Anna Lasorella, Robert Benezra, Antonio Iavarone

ABSTRACT

Inhibitor of DNA binding (ID) proteins are transcriptional regulators that control the timing of cell fate determination and differentiation in stem and progenitor cells during normal development and adult life. ID genes are frequently deregulated in many types of human neoplasms, and they endow cancer cells with biological features that are hijacked from normal stem cells. The ability of ID proteins to function as central 'hubs' for the coordination of multiple cancer hallmarks has established these transcriptional regulators as therapeutic targets and biomarkers in specific types of human tumours. More... »

PAGES

77-91

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    URI

    http://scigraph.springernature.com/pub.10.1038/nrc3638

    DOI

    http://dx.doi.org/10.1038/nrc3638

    DIMENSIONS

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    PUBMED

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