Serine, glycine and one-carbon units: cancer metabolism in full circle View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-08

AUTHORS

Jason W. Locasale

ABSTRACT

One-carbon metabolism involving the folate and methionine cycles integrates nutritional status from amino acids, glucose and vitamins, and generates diverse outputs, such as the biosynthesis of lipids, nucleotides and proteins, the maintenance of redox status and the substrates for methylation reactions. Long considered a 'housekeeping' process, this pathway has recently been shown to have additional complexity. Genetic and functional evidence suggests that hyperactivation of this pathway is a driver of oncogenesis and establishes a link to cellular epigenetic status. Given the wealth of clinically available agents that target one-carbon metabolism, these new findings could present opportunities for translation into precision cancer medicine. More... »

PAGES

572-583

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc3557

    DOI

    http://dx.doi.org/10.1038/nrc3557

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038912868

    PUBMED

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