The role of mutations in epigenetic regulators in myeloid malignancies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-09

AUTHORS

Alan H. Shih, Omar Abdel-Wahab, Jay P. Patel, Ross L. Levine

ABSTRACT

Recent genomic studies have identified novel recurrent somatic mutations in patients with myeloid malignancies, including myeloproliferative neoplasms (MPNs), myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML). In some cases these mutations occur in genes with known roles in regulating chromatin and/or methylation states in haematopoietic progenitors, and in other cases genetic and functional studies have elucidated a role for specific mutations in altering epigenetic patterning in myeloid malignancies. In this Review we discuss recent genetic and functional data implicating mutations in epigenetic modifiers, including tet methylcytosine dioxygenase 2 (TET2), isocitrate dehydrogenase 1 (IDH1), IDH2, additional sex combs-like 1 (ASXL1), enhancer of zeste homologue 2 (EZH2) and DNA methyltransferase 3A (DNMT3A), in the pathogenesis of MPN, MDS and AML, and discuss how this knowledge is leading to novel clinical, biological and therapeutic insights. More... »

PAGES

599

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  • Journal

    TITLE

    Nature Reviews Cancer

    ISSUE

    9

    VOLUME

    12

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc3343

    DOI

    http://dx.doi.org/10.1038/nrc3343

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042261597

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22898539


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