The genetic architecture of multiple myeloma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-05

AUTHORS

Gareth J. Morgan, Brian A. Walker, Faith E. Davies

ABSTRACT

Based on the clinical features of myeloma and related malignancies of plasma cells, it has been possible to generate a model system of myeloma progression from a normal plasma cell through smouldering myeloma to myeloma and then plasma cell leukaemia. Using this model system we can study at which points the genetic alterations identified through whole-tumour molecular analyses function in the initiation and progression of myeloma. Further genetic complexity, such as intraclonal heterogeneity, and insights into the molecular evolution and intraclonal dynamics in this model system are crucial to our understandings of tumour progression, treatment resistance and the use of currently available and future treatments. More... »

PAGES

335

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc3257

    DOI

    http://dx.doi.org/10.1038/nrc3257

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043097699

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22495321


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