Targeting MET in cancer: rationale and progress View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-02

AUTHORS

Ermanno Gherardi, Walter Birchmeier, Carmen Birchmeier, George Vande Woude

ABSTRACT

Uncontrolled cell survival, growth, angiogenesis and metastasis are essential hallmarks of cancer. Genetic and biochemical data have demonstrated that the growth and motility factor hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the tyrosine kinase MET, have a causal role in all of these processes, thus providing a strong rationale for targeting these molecules in cancer. Parallel progress in understanding the structure and function of HGF/SF, MET and associated signalling components has led to the successful development of blocking antibodies and a large number of small-molecule MET kinase inhibitors. In this Review, we discuss these advances, as well as results from recent clinical studies that demonstrate that inhibiting MET signalling in several types of solid human tumours has major therapeutic value. More... »

PAGES

89

References to SciGraph publications

  • 2001-05. Down-regulation of MET, the receptor for hepatocyte growth factor in ONCOGENE
  • 2008-05. Wnt signalling and its impact on development and cancer in NATURE REVIEWS CANCER
  • 1997-05. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas in NATURE GENETICS
  • 1998-01. Role of morphogenetic factors in metastasis of mammary carcinoma cells in ONCOGENE
  • 2008-11. Derailed endocytosis: an emerging feature of cancer in NATURE REVIEWS CANCER
  • 2008-04. Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling in NATURE
  • 2003-11. Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways in ONCOGENE
  • 1984-09. Molecular cloning of a new transforming gene from a chemically transformed human cell line in NATURE
  • 2003-12. Met, metastasis, motility and more in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2006-04. Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases in ONCOGENE
  • 2000-10. A novel germ line juxtamembrane Met mutation in human gastric cancer in ONCOGENE
  • 2006-12. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells in NATURE
  • 2011-07. A direct role for Met endocytosis in tumorigenesis in NATURE CELL BIOLOGY
  • 1996-11. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis in NATURE
  • 1999-01-01. Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 1997-07. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell in NATURE MEDICINE
  • 2010-01. Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors in NATURE
  • 2002-11. Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis in NATURE MEDICINE
  • 2000-03. Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas in ONCOGENE
  • 1987-05. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility in NATURE
  • 1990-07. Hepatocytes and scatter factor in NATURE
  • 2009-01. Crypt stem cells as the cells-of-origin of intestinal cancer in NATURE
  • 2010-05. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment in NATURE CELL BIOLOGY
  • 2010-12. Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition in MOLECULAR CANCER
  • 2002-09. The Semaphorin 4D receptor controls invasive growth by coupling with Met in NATURE CELL BIOLOGY
  • 2002-03. The endophilin–CIN85–Cbl complex mediates ligand-dependent downregulation of c-Met in NATURE
  • 1995-08. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud in NATURE
  • 2004-04. The tumour–stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients in BRITISH JOURNAL OF CANCER
  • 1995-02. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor in NATURE
  • 2010-09. Cell delivery of Met docking site peptides inhibit angiogenesis and vascular tumor growth in ONCOGENE
  • 1995-02. Scatter factor/hepatocyte growth factor is essential for liver development in NATURE
  • 2010-12. MET signalling: principles and functions in development, organ regeneration and cancer in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1998-10. Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis in ONCOGENE
  • 2009-01. MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis in NATURE MEDICINE
  • 1989-11. Molecular cloning and expression of human hepatocyte growth factor in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc3205

    DOI

    http://dx.doi.org/10.1038/nrc3205

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22270953


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