Advances in sarcoma genomics and new therapeutic targets View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-08

AUTHORS

Barry S. Taylor, Jordi Barretina, Robert G. Maki, Cristina R. Antonescu, Samuel Singer, Marc Ladanyi

ABSTRACT

Increasingly, human mesenchymal malignancies are being classified by the abnormalities that drive their pathogenesis. Although many of these aberrations are highly prevalent within particular sarcoma subtypes, few are currently targeted therapeutically. Indeed, most subtypes of sarcoma are still treated with traditional therapeutic modalities, and in many cases sarcomas are resistant to adjuvant therapies. In this Review, we discuss the core molecular determinants of sarcomagenesis and emphasize the emerging genomic and functional genetic approaches that, coupled with novel therapeutic strategies, have the potential to transform the care of patients with sarcoma. More... »

PAGES

541

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    http://scigraph.springernature.com/pub.10.1038/nrc3087

    DOI

    http://dx.doi.org/10.1038/nrc3087

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21753790


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