SWI/SNF nucleosome remodellers and cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-07

AUTHORS

Boris G. Wilson, Charles W. M. Roberts

ABSTRACT

SWI/SNF chromatin remodelling complexes use the energy of ATP hydrolysis to remodel nucleosomes and to modulate transcription. Growing evidence indicates that these complexes have a widespread role in tumour suppression, as inactivating mutations in several SWI/SNF subunits have recently been identified at a high frequency in a variety of cancers. However, the mechanisms by which mutations in these complexes drive tumorigenesis are unclear. In this Review we discuss the contributions of SWI/SNF mutations to cancer formation, examine their normal functions and discuss opportunities for novel therapeutic interventions for SWI/SNF-mutant cancers. More... »

PAGES

481

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc3068

    DOI

    http://dx.doi.org/10.1038/nrc3068

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052801817

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21654818


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