TGFβ signalling: a complex web in cancer progression View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-06

AUTHORS

Hiroaki Ikushima, Kohei Miyazono

ABSTRACT

The distortion of growth factor signalling is the most important prerequisite in tumour progression. Transforming growth factor-beta (TGFbeta) signalling regulates tumour progression by a tumour cell-autonomous mechanism or through tumour-stroma interaction, and has either a tumour-suppressing or tumour-promoting function depending on cellular context. Such inherent complexity of TGFbeta signalling results in arduous, but promising, assignments for developing therapeutic strategies against malignant tumours. As numerous cellular context-dependent factors tightly maintain the balance of TGFbeta signalling and contribute to the regulation of TGFbeta-induced cell responses, in this Review we discuss how they maintain the balance of TGFbeta signalling and how their collapse leads to tumour progression. More... »

PAGES

415

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc2853

    DOI

    http://dx.doi.org/10.1038/nrc2853

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010358767

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20495575


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