Senescence in tumours: evidence from mice and humans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-01

AUTHORS

Manuel Collado, Manuel Serrano

ABSTRACT

The importance of cellular senescence, which is a stress response that stably blocks proliferation, is increasingly being recognized. Senescence is prevalent in pre-malignant tumours, and progression to malignancy requires evading senescence. Malignant tumours, however, may still undergo senescence owing to interventions that restore tumour suppressor function or inactivate oncogenes. Senescent tumour cells can be cleared by immune cells, which may result in efficient tumour regression. Standard chemotherapy also has the potential to induce senescence, which may partly underlie its therapeutic activity. Although these concepts are well supported in mouse models, translating them to clinical oncology remains a challenge. More... »

PAGES

51

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc2772

    DOI

    http://dx.doi.org/10.1038/nrc2772

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003535198

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20029423


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