Ontology type: schema:ScholarlyArticle Open Access: True
2009-11
AUTHORSHua Yu, Drew Pardoll, Richard Jove
ABSTRACTCommensurate with their roles in regulating cytokine-dependent inflammation and immunity, signal transducer and activator of transcription (STAT) proteins are central in determining whether immune responses in the tumour microenvironment promote or inhibit cancer. Persistently activated STAT3 and, to some extent, STAT5 increase tumour cell proliferation, survival and invasion while suppressing anti-tumour immunity. The persistent activation of STAT3 also mediates tumour-promoting inflammation. STAT3 has this dual role in tumour inflammation and immunity by promoting pro-oncogenic inflammatory pathways, including nuclear factor-kappaB (NF-kappaB) and interleukin-6 (IL-6)-GP130-Janus kinase (JAK) pathways, and by opposing STAT1- and NF-kappaB-mediated T helper 1 anti-tumour immune responses. Consequently, STAT3 is a promising target to redirect inflammation for cancer therapy. More... »
PAGES798-809
http://scigraph.springernature.com/pub.10.1038/nrc2734
DOIhttp://dx.doi.org/10.1038/nrc2734
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1022123078
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/19851315
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Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrc2734'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrc2734'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrc2734'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrc2734'
This table displays all metadata directly associated to this object as RDF triples.
622 TRIPLES
21 PREDICATES
193 URIs
29 LITERALS
17 BLANK NODES