Ontology type: schema:ScholarlyArticle Open Access: True
2009-11
AUTHORSHua Yu, Drew Pardoll, Richard Jove
ABSTRACTCommensurate with their roles in regulating cytokine-dependent inflammation and immunity, signal transducer and activator of transcription (STAT) proteins are central in determining whether immune responses in the tumour microenvironment promote or inhibit cancer. Persistently activated STAT3 and, to some extent, STAT5 increase tumour cell proliferation, survival and invasion while suppressing anti-tumour immunity. The persistent activation of STAT3 also mediates tumour-promoting inflammation. STAT3 has this dual role in tumour inflammation and immunity by promoting pro-oncogenic inflammatory pathways, including nuclear factor-kappaB (NF-kappaB) and interleukin-6 (IL-6)-GP130-Janus kinase (JAK) pathways, and by opposing STAT1- and NF-kappaB-mediated T helper 1 anti-tumour immune responses. Consequently, STAT3 is a promising target to redirect inflammation for cancer therapy. More... »
PAGES798-809
http://scigraph.springernature.com/pub.10.1038/nrc2734
DOIhttp://dx.doi.org/10.1038/nrc2734
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1022123078
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/19851315
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "STAT Transcription Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "STAT3 Transcription Factor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "STAT5 Transcription Factor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Signal Transduction",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "City Of Hope National Medical Center",
"id": "https://www.grid.ac/institutes/grid.410425.6",
"name": [
"Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA. hyu@coh.org"
],
"type": "Organization"
},
"familyName": "Yu",
"givenName": "Hua",
"id": "sg:person.01322016332.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322016332.33"
],
"type": "Person"
},
{
"familyName": "Pardoll",
"givenName": "Drew",
"id": "sg:person.012740423777.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012740423777.12"
],
"type": "Person"
},
{
"familyName": "Jove",
"givenName": "Richard",
"id": "sg:person.0613555447.67",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613555447.67"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1182/blood-2006-02-004747",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000080797"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature06309",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000116337",
"https://doi.org/10.1038/nature06309"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature06764",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000219963",
"https://doi.org/10.1038/nature06764"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2009.01.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000455059"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2009.01.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000677027"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-08-0377",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001109520"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1206028",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001510184",
"https://doi.org/10.1038/sj.onc.1206028"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1206028",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001510184",
"https://doi.org/10.1038/sj.onc.1206028"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-08-1191",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001978127"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/stem.23",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002222623"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-08-3031",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003700000"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20090207",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003995427"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1074-7613(00)80011-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004097098"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.180.3.1800",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004146154"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni.1701",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004261929",
"https://doi.org/10.1038/ni.1701"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni.1701",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004261929",
"https://doi.org/10.1038/ni.1701"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri1806",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004289511",
"https://doi.org/10.1038/nri1806"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri1806",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004289511",
"https://doi.org/10.1038/nri1806"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1659",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004822765",
"https://doi.org/10.1038/nm1659"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-04-4359",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006018963"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm.2015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007240913",
"https://doi.org/10.1038/nm.2015"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm.2015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007240913",
"https://doi.org/10.1038/nm.2015"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.341",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007437336",
"https://doi.org/10.1038/ng.341"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1535-7163.mct-08-0138",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008537421"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1208469",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009081514",
"https://doi.org/10.1038/sj.onc.1208469"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1208469",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009081514",
"https://doi.org/10.1038/sj.onc.1208469"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1325",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009280775",
"https://doi.org/10.1038/nm1325"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1325",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009280775",
"https://doi.org/10.1038/nm1325"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri1703",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011428149",
"https://doi.org/10.1038/nri1703"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri1703",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011428149",
"https://doi.org/10.1038/nri1703"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0534764100",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011460516"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci34944",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011737632"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-08-1332",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012679517"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-08-2944",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012812459"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0409467102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013021330"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci3785",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013208689"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni1012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013582066",
"https://doi.org/10.1038/ni1012"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni1012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013582066",
"https://doi.org/10.1038/ni1012"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-08-2419",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015126576"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.r700016200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015184745"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-05-1205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015457622"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1600-065x.2008.00644.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016459308"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-08-4323",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016567543"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.15.3.1312",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018398740"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jaci.2009.05.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018666920"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20080132",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018928789"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-08-4709",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020536431"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2009.01.027",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020649367"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2005.05.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021237636"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2005.05.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021237636"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.131568898",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021378963"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1129139",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021857158"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci35213",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022184238"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0237137100",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022699625"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m511797200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022740191"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.95.13.7556",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022907036"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.immunol.16.1.225",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023386682"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni1213",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024014898",
"https://doi.org/10.1038/ni1213"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni1213",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024014898",
"https://doi.org/10.1038/ni1213"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1535-7163.mct-05-0268",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024091506"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nbt.1564",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024403859",
"https://doi.org/10.1038/nbt.1564"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc780",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024581782",
"https://doi.org/10.1038/nrc780"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc780",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024581782",
"https://doi.org/10.1038/nrc780"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature07205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024729982",
"https://doi.org/10.1038/nature07205"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1359-6101(00)00005-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024883745"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1515/cclm.2008.278",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024962497"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m008802200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025832300"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/cyto.2001.0856",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025849359"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-04-2425",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026166787"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00280-008-0823-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026345777",
"https://doi.org/10.1007/s00280-008-0823-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00280-008-0823-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026345777",
"https://doi.org/10.1007/s00280-008-0823-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1203551",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026415083",
"https://doi.org/10.1038/sj.onc.1203551"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1203551",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026415083",
"https://doi.org/10.1038/sj.onc.1203551"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1203486",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027056444",
"https://doi.org/10.1038/sj.onc.1203486"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1203486",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027056444",
"https://doi.org/10.1038/sj.onc.1203486"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2002-11-3396",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027140523"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0609757104",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027158008"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(00)81959-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027184867"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m803813200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027652796"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1209942",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028771627",
"https://doi.org/10.1038/sj.onc.1209942"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1209942",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028771627",
"https://doi.org/10.1038/sj.onc.1209942"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-08-0613",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028973265"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-06-3350",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029843243"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.0802740",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030269836"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.immunol.15.1.797",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030383304"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m502694200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030394047"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m502694200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030394047"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10165-008-0099-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030639802",
"https://doi.org/10.1007/s10165-008-0099-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1275",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031068002",
"https://doi.org/10.1038/nrc1275"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1275",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031068002",
"https://doi.org/10.1038/nrc1275"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2008-01-134783",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031481003"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2004.08.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031763691"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1535-7163.mct-06-0561",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032325100"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature07475",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032605043",
"https://doi.org/10.1038/nature07475"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2004.07.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032617810"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.biochem.67.1.227",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033786268"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2006.04.025",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033836100"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1207003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034296337",
"https://doi.org/10.1038/sj.onc.1207003"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1207003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034296337",
"https://doi.org/10.1038/sj.onc.1207003"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1140485",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034305158"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri1961",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034368267",
"https://doi.org/10.1038/nri1961"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri1961",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034368267",
"https://doi.org/10.1038/nri1961"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm1368",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035038790",
"https://doi.org/10.1038/nrm1368"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm1368",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035038790",
"https://doi.org/10.1038/nrm1368"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.0105-2896.2004.00192.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035464386"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20071450",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035962542"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature06096",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036072632",
"https://doi.org/10.1038/nature06096"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1096/fj.02-1084fje",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036152385"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.critrevonc.2005.08.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036540455"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1074-7613(03)00232-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037188061"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1074-7613(00)80005-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037464381"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2002-05-1461",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038464111"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrd2781",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039639004",
"https://doi.org/10.1038/nrd2781"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbrc.2008.11.053",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039678394"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj3340297",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041277059"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj3340297",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041277059"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m107527200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041385305"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri1001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041472288",
"https://doi.org/10.1038/nri1001"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri1001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041472288",
"https://doi.org/10.1038/nri1001"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2008-09-179820",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042059453"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature02924",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042163603",
"https://doi.org/10.1038/nature02924"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature02924",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042163603",
"https://doi.org/10.1038/nature02924"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0600666103",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043008105"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1256",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043086899",
"https://doi.org/10.1038/nrc1256"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1256",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043086899",
"https://doi.org/10.1038/nrc1256"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-05-0529",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043123644"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(94)90235-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043206405"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncponc0195",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043471728",
"https://doi.org/10.1038/ncponc0195"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncponc0195",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043471728",
"https://doi.org/10.1038/ncponc0195"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncponc0195",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043471728",
"https://doi.org/10.1038/ncponc0195"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molimm.2009.02.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044155853"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1249",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044465535",
"https://doi.org/10.1038/nm1249"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1249",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044465535",
"https://doi.org/10.1038/nm1249"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1553707",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044910828"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri774",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045044815",
"https://doi.org/10.1038/nri774"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri774",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045044815",
"https://doi.org/10.1038/nri774"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm909",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045111933",
"https://doi.org/10.1038/nrm909"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm909",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045111933",
"https://doi.org/10.1038/nrm909"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.98.4.1543",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045118421"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-07-0858",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045218516"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2009.02.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045384677"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/10428190290026259",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045615281"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-07-0647",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046456862"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc906",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046543214",
"https://doi.org/10.1038/nrc906"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc906",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046543214",
"https://doi.org/10.1038/nrc906"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-06-3955",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046545197"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1100369",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047274383"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2008-02-140673",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047941536"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1096/fj.06-6191com",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047945805"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20051848",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048709192"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12026-007-8014-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049308710",
"https://doi.org/10.1007/s12026-007-8014-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2008-09-177360",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049311314"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm976",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049736419",
"https://doi.org/10.1038/nm976"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm976",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049736419",
"https://doi.org/10.1038/nm976"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2008.12.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050210092"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature04808",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050989342",
"https://doi.org/10.1038/nature04808"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature04808",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050989342",
"https://doi.org/10.1038/nature04808"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.immuni.2008.07.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051064847"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m201941200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051109948"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri1995",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052092567",
"https://doi.org/10.1038/nri1995"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri1995",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052092567",
"https://doi.org/10.1038/nri1995"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2006.07.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052218901"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10456-006-9038-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052401858",
"https://doi.org/10.1007/s10456-006-9038-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10456-006-9038-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052401858",
"https://doi.org/10.1007/s10456-006-9038-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj20030407",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052909234"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj20030407",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052909234"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.chembiol.2006.09.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052981341"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-07-0575",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053443939"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-05-2674",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053539489"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/jm801491w",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055956177"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/jm801491w",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055956177"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/107999099313695",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059207332"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/jir.1998.18.549",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059280520"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1099/0022-1317-83-7-1651",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060362349"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.272.5262.719",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062552914"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.7541555",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062647482"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.7604283",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062648135"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.8140422",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062652919"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.8197455",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062653086"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci21032",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063416583"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci31871",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063416953"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2174/1566524023362456",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1069185471"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4161/cc.3.9.1130",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072298054"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075255986",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076631464",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076811360",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.173.10.6409",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1076962458"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076989474",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.175.5.3354",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077101548"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.178.11.6777",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077420356"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.179.4.2170",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077458175"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.181.1.104",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077663871"
],
"type": "CreativeWork"
}
],
"datePublished": "2009-11",
"datePublishedReg": "2009-11-01",
"description": "Commensurate with their roles in regulating cytokine-dependent inflammation and immunity, signal transducer and activator of transcription (STAT) proteins are central in determining whether immune responses in the tumour microenvironment promote or inhibit cancer. Persistently activated STAT3 and, to some extent, STAT5 increase tumour cell proliferation, survival and invasion while suppressing anti-tumour immunity. The persistent activation of STAT3 also mediates tumour-promoting inflammation. STAT3 has this dual role in tumour inflammation and immunity by promoting pro-oncogenic inflammatory pathways, including nuclear factor-kappaB (NF-kappaB) and interleukin-6 (IL-6)-GP130-Janus kinase (JAK) pathways, and by opposing STAT1- and NF-kappaB-mediated T helper 1 anti-tumour immune responses. Consequently, STAT3 is a promising target to redirect inflammation for cancer therapy.",
"genre": "research_article",
"id": "sg:pub.10.1038/nrc2734",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2438833",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2438791",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1029716",
"issn": [
"1474-175X",
"1474-1768"
],
"name": "Nature Reviews Cancer",
"type": "Periodical"
},
{
"issueNumber": "11",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "9"
}
],
"name": "STATs in cancer inflammation and immunity: a leading role for STAT3",
"pagination": "798-809",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"696665ac17bb8488405bb74cb542ee9a4473e707cffda3c1139208c9a0aa12bd"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"19851315"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101124168"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/nrc2734"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1022123078"
]
}
],
"sameAs": [
"https://doi.org/10.1038/nrc2734",
"https://app.dimensions.ai/details/publication/pub.1022123078"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T13:55",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000424.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/nrc/journal/v9/n11/full/nrc2734.html"
}
]Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrc2734'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrc2734'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrc2734'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrc2734'
This table displays all metadata directly associated to this object as RDF triples.
622 TRIPLES
21 PREDICATES
193 URIs
29 LITERALS
17 BLANK NODES