Tumour suppression by p53: a role for the DNA damage response? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-10

AUTHORS

David W Meek

ABSTRACT

Loss of p53 function occurs during the development of most, if not all, tumour types. This paves the way for genomic instability, tumour-associated changes in metabolism, insensitivity to apoptotic signals, invasiveness and motility. However, the nature of the causal link between early tumorigenic events and the induction of the p53-mediated checkpoints that constitute a barrier to tumour progression remains uncertain. This Review considers the role of the DNA damage response, which is activated during the early stages of tumour development, in mobilizing the tumour suppression function of p53. The relationship between these events and oncogene-induced p53 activation through the ARF pathway is also discussed. More... »

PAGES

714-723

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc2716

    DOI

    http://dx.doi.org/10.1038/nrc2716

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044711949

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19730431


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