p53 and metabolism View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-10

AUTHORS

Karen H Vousden, Kevin M Ryan

ABSTRACT

Although metabolic alterations have been observed in cancer for almost a century, only recently have the mechanisms underlying these changes been identified and the importance of metabolic transformation realized. p53 has been shown to respond to metabolic changes and to influence metabolic pathways through several mechanisms. The contributions of these activities to tumour suppression are complex and potentially rather surprising: some reflect the function of basal p53 levels that do not require overt activation and others might even promote, rather than inhibit, tumour progression. More... »

PAGES

691-700

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc2715

    DOI

    http://dx.doi.org/10.1038/nrc2715

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026112166

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19759539


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