Environment-mediated drug resistance: a major contributor to minimal residual disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-09

AUTHORS

Mark B Meads, Robert A Gatenby, William S Dalton

ABSTRACT

Environment-mediated drug resistance is a form of de novo drug resistance that protects tumour cells from the initial effects of diverse therapies. Surviving foci of residual disease can then develop complex and permanent acquired resistance in response to the selective pressure of therapy. Recent evidence indicates that environment-mediated drug resistance arises from an adaptive, reciprocal signalling dialogue between tumour cells and the surrounding microenvironment. We propose that new therapeutic strategies targeting this interaction should be applied during initial treatment to prevent the emergence of acquired resistance. More... »

PAGES

665-674

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc2714

    DOI

    http://dx.doi.org/10.1038/nrc2714

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020069608

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19693095


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