Signal integration by JNK and p38 MAPK pathways in cancer development View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-08

AUTHORS

Erwin F. Wagner, Ángel R. Nebreda

ABSTRACT

Key PointsJun N-terminal kinases (JNKs) and p38 mitogen-activated protein kinases (MAPKs) have important roles in the signalling mechanisms that orchestrate cellular responses to many types of stresses, but also control the proliferation, differentiation, survival and migration of specific cell types.JNKs and p38 MAPKs can exert antagonistic effects on cell proliferation and survival, which depend on cell type-specific differences, as well as on the intensity and duration of the signal and the crosstalk between other signalling pathways.Crosstalk between the JNK and p38 MAPK pathways is emerging as an important regulatory mechanism in many cellular responses.The JNK and p38 MAPK pathways regulate the activity and expression of key inflammatory mediators, including cytokines and proteases, which may function as potent cancer promoters.The specific role of individual JNK and p38 MAPK family members in particular cellular processes in vivo has been addressed by gene-targeting experiments in mice. Genetically engineered mouse models have confirmed the importance of these pathways for tumorigenesis in various organs.The expression or activity of JNK and p38 MAPK pathway components is often altered in human tumours and cancer cell lines. Given the many tumorigenesis-related functions that these kinases can control, both in the cancer cell and in the tumour microenvironment, it is important to carefully consider the type of tumour before attempting to modulate these pathways for cancer therapy. More... »

PAGES

537-549

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    DOI

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    DIMENSIONS

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    PUBMED

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