The LKB1–AMPK pathway: metabolism and growth control in tumour suppression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-08

AUTHORS

David B Shackelford, Reuben J Shaw

ABSTRACT

In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 encodes a serine-threonine kinase that directly phosphorylates and activates AMPK, a central metabolic sensor. AMPK regulates lipid, cholesterol and glucose metabolism in specialized metabolic tissues, such as liver, muscle and adipose tissue. This function has made AMPK a key therapeutic target in patients with diabetes. The connection of AMPK with several tumour suppressors suggests that therapeutic manipulation of this pathway using established diabetes drugs warrants further investigation in patients with cancer. More... »

PAGES

563-575

References to SciGraph publications

  • 2000-07. A Drosophila melanogaster homologue of Caenorhabditis eleganspar-1 acts at an early step in embryonic-axis formation in NATURE CELL BIOLOGY
  • 2003-01. A role for Drosophila LKB1 in anterior–posterior axis formation and epithelial polarity in NATURE
  • 2008-12. Insulin and insulin-like growth factor signalling in neoplasia in NATURE REVIEWS CANCER
  • 2008-09. The regulation of AMP-activated protein kinase by upstream kinases in INTERNATIONAL JOURNAL OF OBESITY
  • 2007-07. Energy-dependent regulation of cell structure by AMP-activated protein kinase in NATURE
  • 2007-08. LKB1 modulates lung cancer differentiation and metastasis in NATURE
  • 2003-10. LKB1 (XEEK1) regulates Wnt signalling in vertebrate development in NATURE CELL BIOLOGY
  • 2007-06. HIF-1 mediates the Warburg effect in clear cell renal carcinoma in JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
  • 2004-06. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways in NATURE MEDICINE
  • 2006-05. Adiponectin and cancer: a systematic review in BRITISH JOURNAL OF CANCER
  • 2001-03. DNA double-strand breaks: signaling, repair and the cancer connection in NATURE GENETICS
  • 2008-09. Diet and cancer prevention: the roles of observation and experimentation in NATURE REVIEWS CANCER
  • 2007-03. Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer in ONCOGENE
  • 2004-01. Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway in NATURE CELL BIOLOGY
  • 2009-02. How does SIRT1 affect metabolism, senescence and cancer? in NATURE REVIEWS CANCER
  • 2001-07. PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling in NATURE CELL BIOLOGY
  • 2006-03. Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/−p53−/− compound mutant mice in ONCOGENE
  • 2008-04. LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis in NATURE GENETICS
  • 2008-09. Hypoxia, HIF1 and glucose metabolism in the solid tumour in NATURE REVIEWS CANCER
  • 2006-05. Ras, PI(3)K and mTOR signalling controls tumour cell growth in NATURE
  • 2006-11. Par6–aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control in NATURE CELL BIOLOGY
  • 2008-11. LKB1; linking cell structure and tumor suppression in ONCOGENE
  • 2005-06. The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidation in ONCOGENE
  • 2007-07. Dishevelled promotes axon differentiation by regulating atypical protein kinase C in NATURE CELL BIOLOGY
  • 2008-09. Role of LKB1 in lung cancer development in BRITISH JOURNAL OF CANCER
  • 2002-09. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation in NATURE
  • 2007-09. Structural basis for AMP binding to mammalian AMP-activated protein kinase in NATURE
  • 2004-06. Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations in ONCOGENE
  • 1998-01. A serine/threonine kinase gene defective in Peutz–Jeghers syndrome in NATURE
  • 2009-04. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity in NATURE
  • 2007-10. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis in NATURE REVIEWS CANCER
  • 2007-12. Targeted cancer therapies based on the inhibition of DNA strand break repair in ONCOGENE
  • 2004-05. Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene in ONCOGENE
  • 2007-05. SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes in NATURE MEDICINE
  • 2007-05. Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity in NATURE
  • 2006-11. Ras transformation requires metabolic control by 6-phosphofructo-2-kinase in ONCOGENE
  • 2008-03. Mechanisms linking physical activity with cancer in NATURE REVIEWS CANCER
  • 2005-10. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism in NATURE
  • 2007-04. The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge in ONCOGENE
  • 2003-12. Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade in BMC BIOLOGY
  • 2007-02. The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis in NATURE CELL BIOLOGY
  • Journal

    TITLE

    Nature Reviews Cancer

    ISSUE

    8

    VOLUME

    9

    Related Patents

  • Solid Forms Of 3-(5-Amino-2-Methyl-4-Oxo-4h-Quinazolin-3-Yl)-Piperidine-2,6-Dione, And Their Pharmaceutical Compositions And Uses
  • Methods For The Identification And Treatment Of Patients Sensitive To Anti Igf-1r Inhibition Therapy
  • Crispr Mediated Recording Of Cellular Events
  • Pharmaceutical Composition Containing Core Factor Involved In Proliferation And Differentiation Of Central Nervous Cell
  • Methods For The Treatment Of Locally Advanced Breast Cancer
  • Cereblon Isoforms And Their Use As Biomarkers For Therapeutic Treatment
  • Methods For Determining Drug Efficacy Using Cereblon-Associated Proteins
  • Antiproliferative Compounds And Methods Of Use Thereof
  • Methods For The Treatment Of Cancer And Inflammatory Diseases Using Cereblon As A Predictor
  • Solid Forms Of 3-(5-Amino-2-Methyl-4-Oxo-4h-Quinazolin-3-Yl)-Piperidine-2,6-Dione, And Their Pharmaceutical Compositions And Uses
  • Solid Forms Of 3-(5-Amino-2-Methyl-4-Oxo-4h-Quinazolin-3-Yl)-Piperidine-2,6-Dione, And Their Pharmaceutical Compositions And Uses
  • Crispr Mediated In Vivo Modeling And Genetic Screening Of Tumor Growth And Metastasis
  • Delivery, Use And Therapeutic Applications Of The Crispr-Cas Systems And Compositions For Modeling Mutations In Leukocytes
  • Solid Forms Of 3-(5-Amino-2-Methyl-4-Oxo-4h-Quinazolin-3-Yl)-Piperidine-2,6-Dione, And Their Pharmaceutical Compositions And Uses
  • Antiproliferative Compounds And Methods Of Use Thereof
  • Methods For The Treatment Of Cancer And Inflammatory Diseases Using Cereblon As A Predictor
  • Ampk Activator Screening Method, And Ampk Activator
  • Antiproliferative Compounds And Methods Of Use Thereof
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc2676

    DOI

    http://dx.doi.org/10.1038/nrc2676

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001005091

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19629071


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "AMP-Activated Protein Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blood Glucose", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hypoglycemic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Kinase Inhibitors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein-Serine-Threonine Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "TOR Serine-Threonine Kinases", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Salk Institute for Biological Studies", 
              "id": "https://www.grid.ac/institutes/grid.250671.7", 
              "name": [
                "Dulbecco Center for Cancer Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shackelford", 
            "givenName": "David B", 
            "id": "sg:person.01330105744.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330105744.00"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Shaw", 
            "givenName": "Reuben J", 
            "id": "sg:person.01016035335.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016035335.28"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ng.98", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000381092", 
              "https://doi.org/10.1038/ng.98"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-0571", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001541569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2009.01.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001619225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.12.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002022371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.06.055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002200313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.20118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002786618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.c100316200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003080797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-0716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003279597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05828", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003303566", 
              "https://doi.org/10.1038/nature05828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003308924", 
              "https://doi.org/10.1038/sj.onc.1208622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003308924", 
              "https://doi.org/10.1038/sj.onc.1208622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003308924", 
              "https://doi.org/10.1038/sj.onc.1208622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2004.06.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004060955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00383-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004119837"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-6721", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005977242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2006.12.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006327191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0704677104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006402547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(01)00258-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006633820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-0389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006833525"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceb.2006.10.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007172318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20052469", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007487782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.171060098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007568689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.1000038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007831702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.192301399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007929685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m705325200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008272026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/34432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008557848", 
              "https://doi.org/10.1038/34432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/34432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008557848", 
              "https://doi.org/10.1038/34432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210879", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008594663", 
              "https://doi.org/10.1038/sj.onc.1210879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1199104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008693847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1199104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008693847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m409014200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009080304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.01.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009536631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/11.13.1497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009983358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010167330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010167330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010663640", 
              "https://doi.org/10.1038/nrc2562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0808749106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011003270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012108532", 
              "https://doi.org/10.1038/sj.onc.1209709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012108532", 
              "https://doi.org/10.1038/sj.onc.1209709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35083016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012551992", 
              "https://doi.org/10.1038/35083016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35083016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012551992", 
              "https://doi.org/10.1038/35083016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m503824200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012685737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012719310", 
              "https://doi.org/10.1038/nature06030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.122254599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012759056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-5014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013417961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-4007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013573135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2008.11.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013606059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e06-03-0193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013991868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-3091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014059152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35017101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014116044", 
              "https://doi.org/10.1038/35017101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35017101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014116044", 
              "https://doi.org/10.1038/35017101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.02.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014247560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0800796105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014480269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20080281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014937883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20080281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014937883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.016634", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015127537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015450580", 
              "https://doi.org/10.1038/sj.onc.1209207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015450580", 
              "https://doi.org/10.1038/sj.onc.1209207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.04.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015477505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-3025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015506742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-4447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015600124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-4924-2-28", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015797791", 
              "https://doi.org/10.1186/1475-4924-2-28"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m502876200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015807378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m802053200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015835224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-1489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016102675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0705070104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016634413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0005137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017573211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.90.20.9261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017641992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209951", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017779941", 
              "https://doi.org/10.1038/sj.onc.1209951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209951", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017779941", 
              "https://doi.org/10.1038/sj.onc.1209951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-2989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017929444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-6567", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018778194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-3225", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019191879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diabetes.49.12.2063", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019256166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-5074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019603004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-05-0149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019784284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2005.05.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019934484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2005.05.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019934484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1535-6108(03)00187-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020063762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-4149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020233785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00231-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020842632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020978255", 
              "https://doi.org/10.1038/nature06161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-1186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021171574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2007.11.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022250890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(00)00742-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022559975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci30558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022767489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207665", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022876587", 
              "https://doi.org/10.1038/sj.onc.1207665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207665", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022876587", 
              "https://doi.org/10.1038/sj.onc.1207665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022907317", 
              "https://doi.org/10.1038/sj.onc.1210016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022907317", 
              "https://doi.org/10.1038/sj.onc.1210016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20080557", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022938719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20080557", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022938719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.38415.708634.f7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022994993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00166-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023003451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exger.2005.07.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023066380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exger.2005.07.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023066380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2006.07.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023124166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0608531103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023322980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db07-0843", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023792893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2222", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024304300", 
              "https://doi.org/10.1038/nrc2222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(03)00938-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024829840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1938-07.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024844073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yexmp.2008.07.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025111796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m300318200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025434409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.032706", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025478711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2004.09.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025868050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2005.04.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026131960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2005.04.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026131960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1467-789x.2007.00396.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026434458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m700590200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026931990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026989690", 
              "https://doi.org/10.1038/nm1573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200702053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027195530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.22.1630", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027818369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.06.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028271489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028327923", 
              "https://doi.org/10.1038/ncb1603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biochem.75.103004.142702", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028350089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2004.04.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028394300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.0050008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028686736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2004.06.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028832365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200701083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028862299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207502", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029189436", 
              "https://doi.org/10.1038/sj.onc.1207502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207502", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029189436", 
              "https://doi.org/10.1038/sj.onc.1207502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.2001.5627", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029218867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(03)00929-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029247539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.04.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029492922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(04)00114-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029501223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03967", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029571611", 
              "https://doi.org/10.1038/nature03967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03967", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029571611", 
              "https://doi.org/10.1038/nature03967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awm100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029824304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2008.342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029834528", 
              "https://doi.org/10.1038/onc.2008.342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0603781103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030098089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030102468", 
              "https://doi.org/10.1038/ncb1080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030102468", 
              "https://doi.org/10.1038/ncb1080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030642195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2325", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031073097", 
              "https://doi.org/10.1038/nrc2325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031102306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031370745", 
              "https://doi.org/10.1038/nature04869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031370745", 
              "https://doi.org/10.1038/nature04869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031370745", 
              "https://doi.org/10.1038/nature04869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031370745", 
              "https://doi.org/10.1038/nature04869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(03)00560-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031618751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20061520", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032158571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20061520", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032158571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejogrb.2009.04.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032303889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ijo.2008.124", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032503518", 
              "https://doi.org/10.1038/ijo.2008.124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa063564", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032990918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2441", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033094330", 
              "https://doi.org/10.1038/nrc2441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033343259", 
              "https://doi.org/10.1038/nrc2468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20061053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033669711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20061053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033669711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.00329.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033779833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.pharmtox.47.120505.105304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034193056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2008.07.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034365053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-07-0482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034459324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2006.04.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034596364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-5756", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034985371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3480607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035612647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3480607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035612647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2005.01.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035896796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chembiol.2008.10.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036061142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/85798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036425682", 
              "https://doi.org/10.1038/85798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/85798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036425682", 
              "https://doi.org/10.1038/85798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1940-6207.capr-08-0081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036462269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036679711", 
              "https://doi.org/10.1038/nature01045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036679711", 
              "https://doi.org/10.1038/nature01045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.02670", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036903006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa066838", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037798278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2004.08.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038677780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1940-6207.capr-08-0022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038850538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2005.06.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038913057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.03.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039082422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2008.02.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039720368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0610157104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040180419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diacare.29.02.06.dc05-1558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040586212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.02-03-0046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040727699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2006.05.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040950149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmc072500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041368849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041685764", 
              "https://doi.org/10.1038/nature01296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041685764", 
              "https://doi.org/10.1038/nature01296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1256804", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041778627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-5793(87)80292-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042002276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01621-07", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042090625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m806153200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042119030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0900465106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042381548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1485", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043000345", 
              "https://doi.org/10.1038/ncb1485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1485", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043000345", 
              "https://doi.org/10.1038/ncb1485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043581672", 
              "https://doi.org/10.1038/nm1052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043581672", 
              "https://doi.org/10.1038/nm1052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci13505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043705336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci13505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043705336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2007.05.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043775174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0004264", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044355838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.19.6410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044475739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1533136100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044525835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2007.11.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044765308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10863-007-9081-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044851317", 
              "https://doi.org/10.1007/s10863-007-9081-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1363206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045102984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-5169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045173407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045284002", 
              "https://doi.org/10.1038/ncb1537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045284002", 
              "https://doi.org/10.1038/ncb1537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6603051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045595833", 
              "https://doi.org/10.1038/sj.bjc.6603051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6603051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045595833", 
              "https://doi.org/10.1038/sj.bjc.6603051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-1500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046125403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2003.10.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046920965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.10.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047014432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80848-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047324701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600381", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047756561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/gast.2001.23258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048086560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2006.01.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048467635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2005.03.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048555816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m900301200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048842652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2008.11.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049801083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05765", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050127858", 
              "https://doi.org/10.1038/nature05765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050440264", 
              "https://doi.org/10.1038/nature07813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0308061100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050527788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1677/erc-08-0038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050553738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0809136105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050832513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050986935", 
              "https://doi.org/10.1038/nrc2536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20081447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051343817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20081447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051343817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051744512", 
              "https://doi.org/10.1038/ncb1048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051744512", 
              "https://doi.org/10.1038/ncb1048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2007.11.066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051827948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604515", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053576028", 
              "https://doi.org/10.1038/sj.bjc.6604515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053660673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053660673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.taap.2008.08.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053741578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/0264-6021:3480607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056714809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1062074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062445165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1120781", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062453240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2007-1736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064290213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.4240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072290209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cbt.6.10.4787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072294359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.7.12.6016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072299490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.7.24.7241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072299797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074600518", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075034107", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075080938", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077835821", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2009-08", 
        "datePublishedReg": "2009-08-01", 
        "description": "In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 encodes a serine-threonine kinase that directly phosphorylates and activates AMPK, a central metabolic sensor. AMPK regulates lipid, cholesterol and glucose metabolism in specialized metabolic tissues, such as liver, muscle and adipose tissue. This function has made AMPK a key therapeutic target in patients with diabetes. The connection of AMPK with several tumour suppressors suggests that therapeutic manipulation of this pathway using established diabetes drugs warrants further investigation in patients with cancer.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nrc2676", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2682551", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2435835", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2499510", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1029716", 
            "issn": [
              "1474-175X", 
              "1474-1768"
            ], 
            "name": "Nature Reviews Cancer", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "8", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "The LKB1\u2013AMPK pathway: metabolism and growth control in tumour suppression", 
        "pagination": "563-575", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "04ca09cbeaef33359a283221cd89fbc37c16ac1bdb7b8333855050253a7e698e"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "19629071"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101124168"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrc2676"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1001005091"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrc2676", 
          "https://app.dimensions.ai/details/publication/pub.1001005091"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:26", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000345_0000000345/records_64117_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/nrc/journal/v9/n8/full/nrc2676.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrc2676'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrc2676'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrc2676'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrc2676'


     

    This table displays all metadata directly associated to this object as RDF triples.

    776 TRIPLES      21 PREDICATES      244 URIs      34 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrc2676 schema:about N08e553ecaf5d48e59bbb76bfd85a0912
    2 N11aca06aae96495ebfc4b546c9a31320
    3 N2079caaf12664987a8e845e243516306
    4 N2ef2ad083e6e4cc689f10db0db56767f
    5 N44346061fc2b4c37b1382d1213625c3f
    6 N48df95b657da46479dfaec163a592b10
    7 N67aec798d95945aa9df6e94a15fbb303
    8 N8d5481261a304433abd92d742882bfa7
    9 N8ed9c4cf7adc436288459f27c36b706d
    10 N9d714545595047369248e77a35936524
    11 Na9bf8e92ba8d48878e5e833a0896ce35
    12 Nba496330c993499f8401e653671a6197
    13 Nf9a47edf6fec4a02b1493c2139535d1f
    14 anzsrc-for:06
    15 anzsrc-for:0601
    16 schema:author Ne542a3bb6a0740d796edc1a96316dde5
    17 schema:citation sg:pub.10.1007/s10863-007-9081-2
    18 sg:pub.10.1038/34432
    19 sg:pub.10.1038/35017101
    20 sg:pub.10.1038/35083016
    21 sg:pub.10.1038/85798
    22 sg:pub.10.1038/ijo.2008.124
    23 sg:pub.10.1038/nature01045
    24 sg:pub.10.1038/nature01296
    25 sg:pub.10.1038/nature03967
    26 sg:pub.10.1038/nature04869
    27 sg:pub.10.1038/nature05765
    28 sg:pub.10.1038/nature05828
    29 sg:pub.10.1038/nature06030
    30 sg:pub.10.1038/nature06161
    31 sg:pub.10.1038/nature07813
    32 sg:pub.10.1038/ncb1048
    33 sg:pub.10.1038/ncb1080
    34 sg:pub.10.1038/ncb1485
    35 sg:pub.10.1038/ncb1537
    36 sg:pub.10.1038/ncb1603
    37 sg:pub.10.1038/ng.98
    38 sg:pub.10.1038/nm1052
    39 sg:pub.10.1038/nm1573
    40 sg:pub.10.1038/nrc2222
    41 sg:pub.10.1038/nrc2325
    42 sg:pub.10.1038/nrc2441
    43 sg:pub.10.1038/nrc2468
    44 sg:pub.10.1038/nrc2536
    45 sg:pub.10.1038/nrc2562
    46 sg:pub.10.1038/onc.2008.342
    47 sg:pub.10.1038/sj.bjc.6603051
    48 sg:pub.10.1038/sj.bjc.6604515
    49 sg:pub.10.1038/sj.onc.1207502
    50 sg:pub.10.1038/sj.onc.1207665
    51 sg:pub.10.1038/sj.onc.1208622
    52 sg:pub.10.1038/sj.onc.1209207
    53 sg:pub.10.1038/sj.onc.1209709
    54 sg:pub.10.1038/sj.onc.1209951
    55 sg:pub.10.1038/sj.onc.1210016
    56 sg:pub.10.1038/sj.onc.1210879
    57 sg:pub.10.1186/1475-4924-2-28
    58 https://app.dimensions.ai/details/publication/pub.1074600518
    59 https://app.dimensions.ai/details/publication/pub.1075034107
    60 https://app.dimensions.ai/details/publication/pub.1075080938
    61 https://app.dimensions.ai/details/publication/pub.1077835821
    62 https://doi.org/10.1002/gcc.20118
    63 https://doi.org/10.1002/path.2562
    64 https://doi.org/10.1006/bbrc.2001.5627
    65 https://doi.org/10.1016/0014-5793(87)80292-2
    66 https://doi.org/10.1016/j.bbrc.2007.11.013
    67 https://doi.org/10.1016/j.ccr.2004.06.007
    68 https://doi.org/10.1016/j.ccr.2004.06.020
    69 https://doi.org/10.1016/j.ccr.2006.04.023
    70 https://doi.org/10.1016/j.ccr.2007.05.008
    71 https://doi.org/10.1016/j.ccr.2007.11.031
    72 https://doi.org/10.1016/j.ceb.2006.10.005
    73 https://doi.org/10.1016/j.cell.2004.09.015
    74 https://doi.org/10.1016/j.cell.2005.10.024
    75 https://doi.org/10.1016/j.cell.2006.01.016
    76 https://doi.org/10.1016/j.cell.2006.06.055
    77 https://doi.org/10.1016/j.cell.2007.03.025
    78 https://doi.org/10.1016/j.cell.2007.04.012
    79 https://doi.org/10.1016/j.cell.2008.06.028
    80 https://doi.org/10.1016/j.cell.2009.02.025
    81 https://doi.org/10.1016/j.chembiol.2008.10.005
    82 https://doi.org/10.1016/j.cmet.2005.05.009
    83 https://doi.org/10.1016/j.cmet.2005.06.005
    84 https://doi.org/10.1016/j.cmet.2006.05.005
    85 https://doi.org/10.1016/j.cmet.2008.02.011
    86 https://doi.org/10.1016/j.cmet.2008.07.007
    87 https://doi.org/10.1016/j.cmet.2008.11.008
    88 https://doi.org/10.1016/j.cub.2003.10.031
    89 https://doi.org/10.1016/j.cub.2004.04.007
    90 https://doi.org/10.1016/j.cub.2004.08.021
    91 https://doi.org/10.1016/j.cub.2007.11.066
    92 https://doi.org/10.1016/j.cub.2008.11.033
    93 https://doi.org/10.1016/j.devcel.2005.04.011
    94 https://doi.org/10.1016/j.devcel.2009.01.016
    95 https://doi.org/10.1016/j.ejogrb.2009.04.034
    96 https://doi.org/10.1016/j.exger.2005.07.007
    97 https://doi.org/10.1016/j.febslet.2005.01.042
    98 https://doi.org/10.1016/j.molcel.2005.03.027
    99 https://doi.org/10.1016/j.molcel.2006.01.010
    100 https://doi.org/10.1016/j.molcel.2008.03.003
    101 https://doi.org/10.1016/j.molcel.2008.04.009
    102 https://doi.org/10.1016/j.molcel.2008.12.026
    103 https://doi.org/10.1016/j.neuron.2006.12.016
    104 https://doi.org/10.1016/j.taap.2008.08.013
    105 https://doi.org/10.1016/j.yexmp.2008.07.005
    106 https://doi.org/10.1016/s0014-5793(03)00560-x
    107 https://doi.org/10.1016/s0092-8674(00)80848-x
    108 https://doi.org/10.1016/s0092-8674(03)00929-2
    109 https://doi.org/10.1016/s0092-8674(03)00938-3
    110 https://doi.org/10.1016/s0092-8674(04)00114-x
    111 https://doi.org/10.1016/s0960-9822(00)00742-9
    112 https://doi.org/10.1016/s1097-2765(01)00258-1
    113 https://doi.org/10.1016/s1535-6108(03)00187-9
    114 https://doi.org/10.1038/sj.emboj.7600110
    115 https://doi.org/10.1038/sj.emboj.7600381
    116 https://doi.org/10.1038/sj.emboj.7600719
    117 https://doi.org/10.1042/0264-6021:3480607
    118 https://doi.org/10.1042/bj20061053
    119 https://doi.org/10.1042/bj20061520
    120 https://doi.org/10.1042/bj20080281
    121 https://doi.org/10.1042/bj20080557
    122 https://doi.org/10.1042/bj20081447
    123 https://doi.org/10.1042/bj3480607
    124 https://doi.org/10.1053/gast.2001.23258
    125 https://doi.org/10.1053/j.gastro.2006.07.032
    126 https://doi.org/10.1056/nejmc072500
    127 https://doi.org/10.1056/nejmoa063564
    128 https://doi.org/10.1056/nejmoa066838
    129 https://doi.org/10.1073/pnas.0308061100
    130 https://doi.org/10.1073/pnas.0603781103
    131 https://doi.org/10.1073/pnas.0608531103
    132 https://doi.org/10.1073/pnas.0610157104
    133 https://doi.org/10.1073/pnas.0704677104
    134 https://doi.org/10.1073/pnas.0705070104
    135 https://doi.org/10.1073/pnas.0800796105
    136 https://doi.org/10.1073/pnas.0808749106
    137 https://doi.org/10.1073/pnas.0809136105
    138 https://doi.org/10.1073/pnas.0900465106
    139 https://doi.org/10.1073/pnas.122254599
    140 https://doi.org/10.1073/pnas.1533136100
    141 https://doi.org/10.1073/pnas.171060098
    142 https://doi.org/10.1073/pnas.192301399
    143 https://doi.org/10.1073/pnas.90.20.9261
    144 https://doi.org/10.1074/jbc.c100316200
    145 https://doi.org/10.1074/jbc.m300318200
    146 https://doi.org/10.1074/jbc.m409014200
    147 https://doi.org/10.1074/jbc.m502876200
    148 https://doi.org/10.1074/jbc.m503824200
    149 https://doi.org/10.1074/jbc.m700590200
    150 https://doi.org/10.1074/jbc.m705325200
    151 https://doi.org/10.1074/jbc.m802053200
    152 https://doi.org/10.1074/jbc.m806153200
    153 https://doi.org/10.1074/jbc.m900301200
    154 https://doi.org/10.1083/jcb.200701083
    155 https://doi.org/10.1083/jcb.200702053
    156 https://doi.org/10.1084/jem.20052469
    157 https://doi.org/10.1091/mbc.02-03-0046
    158 https://doi.org/10.1091/mbc.e06-03-0193
    159 https://doi.org/10.1093/brain/awm100
    160 https://doi.org/10.1093/hmg/11.13.1497
    161 https://doi.org/10.1101/gad.1199104
    162 https://doi.org/10.1101/gad.1256804
    163 https://doi.org/10.1101/gad.1363206
    164 https://doi.org/10.1111/j.1467-789x.2007.00396.x
    165 https://doi.org/10.1126/science.1062074
    166 https://doi.org/10.1126/science.1120781
    167 https://doi.org/10.1128/mcb.00166-06
    168 https://doi.org/10.1128/mcb.00231-06
    169 https://doi.org/10.1128/mcb.00383-06
    170 https://doi.org/10.1128/mcb.01621-07
    171 https://doi.org/10.1136/bmj.38415.708634.f7
    172 https://doi.org/10.1146/annurev.biochem.75.103004.142702
    173 https://doi.org/10.1146/annurev.pharmtox.47.120505.105304
    174 https://doi.org/10.1152/ajpheart.00329.2006
    175 https://doi.org/10.1158/0008-5472.can-04-3025
    176 https://doi.org/10.1158/0008-5472.can-05-0571
    177 https://doi.org/10.1158/0008-5472.can-05-0716
    178 https://doi.org/10.1158/0008-5472.can-05-1489
    179 https://doi.org/10.1158/0008-5472.can-06-1500
    180 https://doi.org/10.1158/0008-5472.can-06-4149
    181 https://doi.org/10.1158/0008-5472.can-06-4447
    182 https://doi.org/10.1158/0008-5472.can-07-0389
    183 https://doi.org/10.1158/0008-5472.can-07-2989
    184 https://doi.org/10.1158/0008-5472.can-07-3091
    185 https://doi.org/10.1158/0008-5472.can-07-3225
    186 https://doi.org/10.1158/0008-5472.can-07-5014
    187 https://doi.org/10.1158/0008-5472.can-07-5169
    188 https://doi.org/10.1158/0008-5472.can-07-5756
    189 https://doi.org/10.1158/0008-5472.can-07-6567
    190 https://doi.org/10.1158/0008-5472.can-07-6721
    191 https://doi.org/10.1158/1078-0432.ccr-05-0149
    192 https://doi.org/10.1158/1078-0432.ccr-07-1186
    193 https://doi.org/10.1158/1078-0432.ccr-07-4007
    194 https://doi.org/10.1158/1078-0432.ccr-07-5074
    195 https://doi.org/10.1158/1535-7163.mct-07-0482
    196 https://doi.org/10.1158/1940-6207.capr-08-0022
    197 https://doi.org/10.1158/1940-6207.capr-08-0081
    198 https://doi.org/10.1172/jci13505
    199 https://doi.org/10.1172/jci30558
    200 https://doi.org/10.1200/jco.2009.19.6410
    201 https://doi.org/10.1200/jco.2009.22.1630
    202 https://doi.org/10.1210/jc.2007-1736
    203 https://doi.org/10.1242/jcs.016634
    204 https://doi.org/10.1242/jcs.02670
    205 https://doi.org/10.1242/jcs.032706
    206 https://doi.org/10.1371/journal.pbio.1000038
    207 https://doi.org/10.1371/journal.pmed.0050008
    208 https://doi.org/10.1371/journal.pone.0004264
    209 https://doi.org/10.1371/journal.pone.0005137
    210 https://doi.org/10.1523/jneurosci.1938-07.2007
    211 https://doi.org/10.1677/erc-08-0038
    212 https://doi.org/10.2337/db07-0843
    213 https://doi.org/10.2337/diabetes.49.12.2063
    214 https://doi.org/10.2337/diacare.29.02.06.dc05-1558
    215 https://doi.org/10.4161/auto.4240
    216 https://doi.org/10.4161/cbt.6.10.4787
    217 https://doi.org/10.4161/cc.7.12.6016
    218 https://doi.org/10.4161/cc.7.24.7241
    219 schema:datePublished 2009-08
    220 schema:datePublishedReg 2009-08-01
    221 schema:description In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 encodes a serine-threonine kinase that directly phosphorylates and activates AMPK, a central metabolic sensor. AMPK regulates lipid, cholesterol and glucose metabolism in specialized metabolic tissues, such as liver, muscle and adipose tissue. This function has made AMPK a key therapeutic target in patients with diabetes. The connection of AMPK with several tumour suppressors suggests that therapeutic manipulation of this pathway using established diabetes drugs warrants further investigation in patients with cancer.
    222 schema:genre research_article
    223 schema:inLanguage en
    224 schema:isAccessibleForFree true
    225 schema:isPartOf N1791e6f322de484cafca48c25fbd55e1
    226 N4fd243ecf1b1448392beb65878044083
    227 sg:journal.1029716
    228 schema:name The LKB1–AMPK pathway: metabolism and growth control in tumour suppression
    229 schema:pagination 563-575
    230 schema:productId N0abed75d10d44d638ba2a0571a34369a
    231 N83e31d169df345aeb096d3281913dd15
    232 N8882eb630ff74666bd84e0c03a8c34f3
    233 Nb1f7cef6c8b24bc6957359dbeb1977b4
    234 Ne6b844c017174c5fb8409836bf70b536
    235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001005091
    236 https://doi.org/10.1038/nrc2676
    237 schema:sdDatePublished 2019-04-11T09:26
    238 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    239 schema:sdPublisher N794aa6fc98af46a1877e6f7a6ce0f9f3
    240 schema:url http://www.nature.com/nrc/journal/v9/n8/full/nrc2676.html
    241 sgo:license sg:explorer/license/
    242 sgo:sdDataset articles
    243 rdf:type schema:ScholarlyArticle
    244 N08e553ecaf5d48e59bbb76bfd85a0912 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    245 schema:name TOR Serine-Threonine Kinases
    246 rdf:type schema:DefinedTerm
    247 N0abed75d10d44d638ba2a0571a34369a schema:name dimensions_id
    248 schema:value pub.1001005091
    249 rdf:type schema:PropertyValue
    250 N11aca06aae96495ebfc4b546c9a31320 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    251 schema:name Mice
    252 rdf:type schema:DefinedTerm
    253 N1791e6f322de484cafca48c25fbd55e1 schema:volumeNumber 9
    254 rdf:type schema:PublicationVolume
    255 N2079caaf12664987a8e845e243516306 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    256 schema:name Protein-Serine-Threonine Kinases
    257 rdf:type schema:DefinedTerm
    258 N2ef2ad083e6e4cc689f10db0db56767f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    259 schema:name Animals
    260 rdf:type schema:DefinedTerm
    261 N44346061fc2b4c37b1382d1213625c3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    262 schema:name Signal Transduction
    263 rdf:type schema:DefinedTerm
    264 N48df95b657da46479dfaec163a592b10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    265 schema:name Blood Glucose
    266 rdf:type schema:DefinedTerm
    267 N4fd243ecf1b1448392beb65878044083 schema:issueNumber 8
    268 rdf:type schema:PublicationIssue
    269 N64efe9549ab846b69857647b64aa83bc rdf:first sg:person.01016035335.28
    270 rdf:rest rdf:nil
    271 N67aec798d95945aa9df6e94a15fbb303 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    272 schema:name Neoplasms
    273 rdf:type schema:DefinedTerm
    274 N794aa6fc98af46a1877e6f7a6ce0f9f3 schema:name Springer Nature - SN SciGraph project
    275 rdf:type schema:Organization
    276 N83e31d169df345aeb096d3281913dd15 schema:name pubmed_id
    277 schema:value 19629071
    278 rdf:type schema:PropertyValue
    279 N8882eb630ff74666bd84e0c03a8c34f3 schema:name readcube_id
    280 schema:value 04ca09cbeaef33359a283221cd89fbc37c16ac1bdb7b8333855050253a7e698e
    281 rdf:type schema:PropertyValue
    282 N8d5481261a304433abd92d742882bfa7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    283 schema:name Protein Kinases
    284 rdf:type schema:DefinedTerm
    285 N8ed9c4cf7adc436288459f27c36b706d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    286 schema:name Hypoglycemic Agents
    287 rdf:type schema:DefinedTerm
    288 N9d714545595047369248e77a35936524 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    289 schema:name Humans
    290 rdf:type schema:DefinedTerm
    291 Na9bf8e92ba8d48878e5e833a0896ce35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    292 schema:name AMP-Activated Protein Kinases
    293 rdf:type schema:DefinedTerm
    294 Nb1f7cef6c8b24bc6957359dbeb1977b4 schema:name nlm_unique_id
    295 schema:value 101124168
    296 rdf:type schema:PropertyValue
    297 Nba496330c993499f8401e653671a6197 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    298 schema:name Disease Models, Animal
    299 rdf:type schema:DefinedTerm
    300 Ne542a3bb6a0740d796edc1a96316dde5 rdf:first sg:person.01330105744.00
    301 rdf:rest N64efe9549ab846b69857647b64aa83bc
    302 Ne6b844c017174c5fb8409836bf70b536 schema:name doi
    303 schema:value 10.1038/nrc2676
    304 rdf:type schema:PropertyValue
    305 Nf9a47edf6fec4a02b1493c2139535d1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    306 schema:name Protein Kinase Inhibitors
    307 rdf:type schema:DefinedTerm
    308 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    309 schema:name Biological Sciences
    310 rdf:type schema:DefinedTerm
    311 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    312 schema:name Biochemistry and Cell Biology
    313 rdf:type schema:DefinedTerm
    314 sg:grant.2435835 http://pending.schema.org/fundedItem sg:pub.10.1038/nrc2676
    315 rdf:type schema:MonetaryGrant
    316 sg:grant.2499510 http://pending.schema.org/fundedItem sg:pub.10.1038/nrc2676
    317 rdf:type schema:MonetaryGrant
    318 sg:grant.2682551 http://pending.schema.org/fundedItem sg:pub.10.1038/nrc2676
    319 rdf:type schema:MonetaryGrant
    320 sg:journal.1029716 schema:issn 1474-175X
    321 1474-1768
    322 schema:name Nature Reviews Cancer
    323 rdf:type schema:Periodical
    324 sg:person.01016035335.28 schema:familyName Shaw
    325 schema:givenName Reuben J
    326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016035335.28
    327 rdf:type schema:Person
    328 sg:person.01330105744.00 schema:affiliation https://www.grid.ac/institutes/grid.250671.7
    329 schema:familyName Shackelford
    330 schema:givenName David B
    331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330105744.00
    332 rdf:type schema:Person
    333 sg:pub.10.1007/s10863-007-9081-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044851317
    334 https://doi.org/10.1007/s10863-007-9081-2
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/34432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008557848
    337 https://doi.org/10.1038/34432
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/35017101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014116044
    340 https://doi.org/10.1038/35017101
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/35083016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012551992
    343 https://doi.org/10.1038/35083016
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/85798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036425682
    346 https://doi.org/10.1038/85798
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/ijo.2008.124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032503518
    349 https://doi.org/10.1038/ijo.2008.124
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/nature01045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036679711
    352 https://doi.org/10.1038/nature01045
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/nature01296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041685764
    355 https://doi.org/10.1038/nature01296
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/nature03967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029571611
    358 https://doi.org/10.1038/nature03967
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/nature04869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031370745
    361 https://doi.org/10.1038/nature04869
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/nature05765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050127858
    364 https://doi.org/10.1038/nature05765
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/nature05828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003303566
    367 https://doi.org/10.1038/nature05828
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1038/nature06030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012719310
    370 https://doi.org/10.1038/nature06030
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1038/nature06161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020978255
    373 https://doi.org/10.1038/nature06161
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1038/nature07813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050440264
    376 https://doi.org/10.1038/nature07813
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.1038/ncb1048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051744512
    379 https://doi.org/10.1038/ncb1048
    380 rdf:type schema:CreativeWork
    381 sg:pub.10.1038/ncb1080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030102468
    382 https://doi.org/10.1038/ncb1080
    383 rdf:type schema:CreativeWork
    384 sg:pub.10.1038/ncb1485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043000345
    385 https://doi.org/10.1038/ncb1485
    386 rdf:type schema:CreativeWork
    387 sg:pub.10.1038/ncb1537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045284002
    388 https://doi.org/10.1038/ncb1537
    389 rdf:type schema:CreativeWork
    390 sg:pub.10.1038/ncb1603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028327923
    391 https://doi.org/10.1038/ncb1603
    392 rdf:type schema:CreativeWork
    393 sg:pub.10.1038/ng.98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000381092
    394 https://doi.org/10.1038/ng.98
    395 rdf:type schema:CreativeWork
    396 sg:pub.10.1038/nm1052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043581672
    397 https://doi.org/10.1038/nm1052
    398 rdf:type schema:CreativeWork
    399 sg:pub.10.1038/nm1573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026989690
    400 https://doi.org/10.1038/nm1573
    401 rdf:type schema:CreativeWork
    402 sg:pub.10.1038/nrc2222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024304300
    403 https://doi.org/10.1038/nrc2222
    404 rdf:type schema:CreativeWork
    405 sg:pub.10.1038/nrc2325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031073097
    406 https://doi.org/10.1038/nrc2325
    407 rdf:type schema:CreativeWork
    408 sg:pub.10.1038/nrc2441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033094330
    409 https://doi.org/10.1038/nrc2441
    410 rdf:type schema:CreativeWork
    411 sg:pub.10.1038/nrc2468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033343259
    412 https://doi.org/10.1038/nrc2468
    413 rdf:type schema:CreativeWork
    414 sg:pub.10.1038/nrc2536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050986935
    415 https://doi.org/10.1038/nrc2536
    416 rdf:type schema:CreativeWork
    417 sg:pub.10.1038/nrc2562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010663640
    418 https://doi.org/10.1038/nrc2562
    419 rdf:type schema:CreativeWork
    420 sg:pub.10.1038/onc.2008.342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029834528
    421 https://doi.org/10.1038/onc.2008.342
    422 rdf:type schema:CreativeWork
    423 sg:pub.10.1038/sj.bjc.6603051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045595833
    424 https://doi.org/10.1038/sj.bjc.6603051
    425 rdf:type schema:CreativeWork
    426 sg:pub.10.1038/sj.bjc.6604515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053576028
    427 https://doi.org/10.1038/sj.bjc.6604515
    428 rdf:type schema:CreativeWork
    429 sg:pub.10.1038/sj.onc.1207502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029189436
    430 https://doi.org/10.1038/sj.onc.1207502
    431 rdf:type schema:CreativeWork
    432 sg:pub.10.1038/sj.onc.1207665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022876587
    433 https://doi.org/10.1038/sj.onc.1207665
    434 rdf:type schema:CreativeWork
    435 sg:pub.10.1038/sj.onc.1208622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003308924
    436 https://doi.org/10.1038/sj.onc.1208622
    437 rdf:type schema:CreativeWork
    438 sg:pub.10.1038/sj.onc.1209207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015450580
    439 https://doi.org/10.1038/sj.onc.1209207
    440 rdf:type schema:CreativeWork
    441 sg:pub.10.1038/sj.onc.1209709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012108532
    442 https://doi.org/10.1038/sj.onc.1209709
    443 rdf:type schema:CreativeWork
    444 sg:pub.10.1038/sj.onc.1209951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017779941
    445 https://doi.org/10.1038/sj.onc.1209951
    446 rdf:type schema:CreativeWork
    447 sg:pub.10.1038/sj.onc.1210016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022907317
    448 https://doi.org/10.1038/sj.onc.1210016
    449 rdf:type schema:CreativeWork
    450 sg:pub.10.1038/sj.onc.1210879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008594663
    451 https://doi.org/10.1038/sj.onc.1210879
    452 rdf:type schema:CreativeWork
    453 sg:pub.10.1186/1475-4924-2-28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015797791
    454 https://doi.org/10.1186/1475-4924-2-28
    455 rdf:type schema:CreativeWork
    456 https://app.dimensions.ai/details/publication/pub.1074600518 schema:CreativeWork
    457 https://app.dimensions.ai/details/publication/pub.1075034107 schema:CreativeWork
    458 https://app.dimensions.ai/details/publication/pub.1075080938 schema:CreativeWork
    459 https://app.dimensions.ai/details/publication/pub.1077835821 schema:CreativeWork
    460 https://doi.org/10.1002/gcc.20118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002786618
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1002/path.2562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053660673
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1006/bbrc.2001.5627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029218867
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1016/0014-5793(87)80292-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042002276
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1016/j.bbrc.2007.11.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022250890
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1016/j.ccr.2004.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028832365
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1016/j.ccr.2004.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004060955
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1016/j.ccr.2006.04.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034596364
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1016/j.ccr.2007.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043775174
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1016/j.ccr.2007.11.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044765308
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1016/j.ceb.2006.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007172318
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1016/j.cell.2004.09.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025868050
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1016/j.cell.2005.10.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047014432
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1016/j.cell.2006.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009536631
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1016/j.cell.2006.06.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002200313
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1016/j.cell.2007.03.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039082422
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1016/j.cell.2007.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015477505
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1016/j.cell.2008.06.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028271489
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1016/j.cell.2009.02.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014247560
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1016/j.chembiol.2008.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036061142
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1016/j.cmet.2005.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019934484
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1016/j.cmet.2005.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038913057
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1016/j.cmet.2006.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040950149
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1016/j.cmet.2008.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039720368
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1016/j.cmet.2008.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034365053
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.1016/j.cmet.2008.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013606059
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.1016/j.cub.2003.10.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046920965
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.1016/j.cub.2004.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028394300
    515 rdf:type schema:CreativeWork
    516 https://doi.org/10.1016/j.cub.2004.08.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038677780
    517 rdf:type schema:CreativeWork
    518 https://doi.org/10.1016/j.cub.2007.11.066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051827948
    519 rdf:type schema:CreativeWork
    520 https://doi.org/10.1016/j.cub.2008.11.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049801083
    521 rdf:type schema:CreativeWork
    522 https://doi.org/10.1016/j.devcel.2005.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026131960
    523 rdf:type schema:CreativeWork
    524 https://doi.org/10.1016/j.devcel.2009.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001619225
    525 rdf:type schema:CreativeWork
    526 https://doi.org/10.1016/j.ejogrb.2009.04.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032303889
    527 rdf:type schema:CreativeWork
    528 https://doi.org/10.1016/j.exger.2005.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023066380
    529 rdf:type schema:CreativeWork
    530 https://doi.org/10.1016/j.febslet.2005.01.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035896796
    531 rdf:type schema:CreativeWork
    532 https://doi.org/10.1016/j.molcel.2005.03.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048555816
    533 rdf:type schema:CreativeWork
    534 https://doi.org/10.1016/j.molcel.2006.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048467635
    535 rdf:type schema:CreativeWork
    536 https://doi.org/10.1016/j.molcel.2008.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031102306
    537 rdf:type schema:CreativeWork
    538 https://doi.org/10.1016/j.molcel.2008.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029492922
    539 rdf:type schema:CreativeWork
    540 https://doi.org/10.1016/j.molcel.2008.12.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002022371
    541 rdf:type schema:CreativeWork
    542 https://doi.org/10.1016/j.neuron.2006.12.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006327191
    543 rdf:type schema:CreativeWork
    544 https://doi.org/10.1016/j.taap.2008.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053741578
    545 rdf:type schema:CreativeWork
    546 https://doi.org/10.1016/j.yexmp.2008.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025111796
    547 rdf:type schema:CreativeWork
    548 https://doi.org/10.1016/s0014-5793(03)00560-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031618751
    549 rdf:type schema:CreativeWork
    550 https://doi.org/10.1016/s0092-8674(00)80848-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047324701
    551 rdf:type schema:CreativeWork
    552 https://doi.org/10.1016/s0092-8674(03)00929-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029247539
    553 rdf:type schema:CreativeWork
    554 https://doi.org/10.1016/s0092-8674(03)00938-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024829840
    555 rdf:type schema:CreativeWork
    556 https://doi.org/10.1016/s0092-8674(04)00114-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029501223
    557 rdf:type schema:CreativeWork
    558 https://doi.org/10.1016/s0960-9822(00)00742-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022559975
    559 rdf:type schema:CreativeWork
    560 https://doi.org/10.1016/s1097-2765(01)00258-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006633820
    561 rdf:type schema:CreativeWork
    562 https://doi.org/10.1016/s1535-6108(03)00187-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020063762
    563 rdf:type schema:CreativeWork
    564 https://doi.org/10.1038/sj.emboj.7600110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030642195
    565 rdf:type schema:CreativeWork
    566 https://doi.org/10.1038/sj.emboj.7600381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047756561
    567 rdf:type schema:CreativeWork
    568 https://doi.org/10.1038/sj.emboj.7600719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010167330
    569 rdf:type schema:CreativeWork
    570 https://doi.org/10.1042/0264-6021:3480607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056714809
    571 rdf:type schema:CreativeWork
    572 https://doi.org/10.1042/bj20061053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033669711
    573 rdf:type schema:CreativeWork
    574 https://doi.org/10.1042/bj20061520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032158571
    575 rdf:type schema:CreativeWork
    576 https://doi.org/10.1042/bj20080281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014937883
    577 rdf:type schema:CreativeWork
    578 https://doi.org/10.1042/bj20080557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022938719
    579 rdf:type schema:CreativeWork
    580 https://doi.org/10.1042/bj20081447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051343817
    581 rdf:type schema:CreativeWork
    582 https://doi.org/10.1042/bj3480607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035612647
    583 rdf:type schema:CreativeWork
    584 https://doi.org/10.1053/gast.2001.23258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048086560
    585 rdf:type schema:CreativeWork
    586 https://doi.org/10.1053/j.gastro.2006.07.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023124166
    587 rdf:type schema:CreativeWork
    588 https://doi.org/10.1056/nejmc072500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041368849
    589 rdf:type schema:CreativeWork
    590 https://doi.org/10.1056/nejmoa063564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032990918
    591 rdf:type schema:CreativeWork
    592 https://doi.org/10.1056/nejmoa066838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037798278
    593 rdf:type schema:CreativeWork
    594 https://doi.org/10.1073/pnas.0308061100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050527788
    595 rdf:type schema:CreativeWork
    596 https://doi.org/10.1073/pnas.0603781103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030098089
    597 rdf:type schema:CreativeWork
    598 https://doi.org/10.1073/pnas.0608531103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023322980
    599 rdf:type schema:CreativeWork
    600 https://doi.org/10.1073/pnas.0610157104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040180419
    601 rdf:type schema:CreativeWork
    602 https://doi.org/10.1073/pnas.0704677104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006402547
    603 rdf:type schema:CreativeWork
    604 https://doi.org/10.1073/pnas.0705070104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016634413
    605 rdf:type schema:CreativeWork
    606 https://doi.org/10.1073/pnas.0800796105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014480269
    607 rdf:type schema:CreativeWork
    608 https://doi.org/10.1073/pnas.0808749106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011003270
    609 rdf:type schema:CreativeWork
    610 https://doi.org/10.1073/pnas.0809136105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050832513
    611 rdf:type schema:CreativeWork
    612 https://doi.org/10.1073/pnas.0900465106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042381548
    613 rdf:type schema:CreativeWork
    614 https://doi.org/10.1073/pnas.122254599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012759056
    615 rdf:type schema:CreativeWork
    616 https://doi.org/10.1073/pnas.1533136100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044525835
    617 rdf:type schema:CreativeWork
    618 https://doi.org/10.1073/pnas.171060098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007568689
    619 rdf:type schema:CreativeWork
    620 https://doi.org/10.1073/pnas.192301399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007929685
    621 rdf:type schema:CreativeWork
    622 https://doi.org/10.1073/pnas.90.20.9261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017641992
    623 rdf:type schema:CreativeWork
    624 https://doi.org/10.1074/jbc.c100316200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003080797
    625 rdf:type schema:CreativeWork
    626 https://doi.org/10.1074/jbc.m300318200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025434409
    627 rdf:type schema:CreativeWork
    628 https://doi.org/10.1074/jbc.m409014200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009080304
    629 rdf:type schema:CreativeWork
    630 https://doi.org/10.1074/jbc.m502876200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015807378
    631 rdf:type schema:CreativeWork
    632 https://doi.org/10.1074/jbc.m503824200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012685737
    633 rdf:type schema:CreativeWork
    634 https://doi.org/10.1074/jbc.m700590200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026931990
    635 rdf:type schema:CreativeWork
    636 https://doi.org/10.1074/jbc.m705325200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008272026
    637 rdf:type schema:CreativeWork
    638 https://doi.org/10.1074/jbc.m802053200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015835224
    639 rdf:type schema:CreativeWork
    640 https://doi.org/10.1074/jbc.m806153200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042119030
    641 rdf:type schema:CreativeWork
    642 https://doi.org/10.1074/jbc.m900301200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048842652
    643 rdf:type schema:CreativeWork
    644 https://doi.org/10.1083/jcb.200701083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028862299
    645 rdf:type schema:CreativeWork
    646 https://doi.org/10.1083/jcb.200702053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027195530
    647 rdf:type schema:CreativeWork
    648 https://doi.org/10.1084/jem.20052469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007487782
    649 rdf:type schema:CreativeWork
    650 https://doi.org/10.1091/mbc.02-03-0046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040727699
    651 rdf:type schema:CreativeWork
    652 https://doi.org/10.1091/mbc.e06-03-0193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013991868
    653 rdf:type schema:CreativeWork
    654 https://doi.org/10.1093/brain/awm100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029824304
    655 rdf:type schema:CreativeWork
    656 https://doi.org/10.1093/hmg/11.13.1497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009983358
    657 rdf:type schema:CreativeWork
    658 https://doi.org/10.1101/gad.1199104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008693847
    659 rdf:type schema:CreativeWork
    660 https://doi.org/10.1101/gad.1256804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041778627
    661 rdf:type schema:CreativeWork
    662 https://doi.org/10.1101/gad.1363206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045102984
    663 rdf:type schema:CreativeWork
    664 https://doi.org/10.1111/j.1467-789x.2007.00396.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026434458
    665 rdf:type schema:CreativeWork
    666 https://doi.org/10.1126/science.1062074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445165
    667 rdf:type schema:CreativeWork
    668 https://doi.org/10.1126/science.1120781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062453240
    669 rdf:type schema:CreativeWork
    670 https://doi.org/10.1128/mcb.00166-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023003451
    671 rdf:type schema:CreativeWork
    672 https://doi.org/10.1128/mcb.00231-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020842632
    673 rdf:type schema:CreativeWork
    674 https://doi.org/10.1128/mcb.00383-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004119837
    675 rdf:type schema:CreativeWork
    676 https://doi.org/10.1128/mcb.01621-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042090625
    677 rdf:type schema:CreativeWork
    678 https://doi.org/10.1136/bmj.38415.708634.f7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022994993
    679 rdf:type schema:CreativeWork
    680 https://doi.org/10.1146/annurev.biochem.75.103004.142702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028350089
    681 rdf:type schema:CreativeWork
    682 https://doi.org/10.1146/annurev.pharmtox.47.120505.105304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034193056
    683 rdf:type schema:CreativeWork
    684 https://doi.org/10.1152/ajpheart.00329.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033779833
    685 rdf:type schema:CreativeWork
    686 https://doi.org/10.1158/0008-5472.can-04-3025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015506742
    687 rdf:type schema:CreativeWork
    688 https://doi.org/10.1158/0008-5472.can-05-0571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001541569
    689 rdf:type schema:CreativeWork
    690 https://doi.org/10.1158/0008-5472.can-05-0716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003279597
    691 rdf:type schema:CreativeWork
    692 https://doi.org/10.1158/0008-5472.can-05-1489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016102675
    693 rdf:type schema:CreativeWork
    694 https://doi.org/10.1158/0008-5472.can-06-1500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046125403
    695 rdf:type schema:CreativeWork
    696 https://doi.org/10.1158/0008-5472.can-06-4149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020233785
    697 rdf:type schema:CreativeWork
    698 https://doi.org/10.1158/0008-5472.can-06-4447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015600124
    699 rdf:type schema:CreativeWork
    700 https://doi.org/10.1158/0008-5472.can-07-0389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006833525
    701 rdf:type schema:CreativeWork
    702 https://doi.org/10.1158/0008-5472.can-07-2989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017929444
    703 rdf:type schema:CreativeWork
    704 https://doi.org/10.1158/0008-5472.can-07-3091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014059152
    705 rdf:type schema:CreativeWork
    706 https://doi.org/10.1158/0008-5472.can-07-3225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019191879
    707 rdf:type schema:CreativeWork
    708 https://doi.org/10.1158/0008-5472.can-07-5014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013417961
    709 rdf:type schema:CreativeWork
    710 https://doi.org/10.1158/0008-5472.can-07-5169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045173407
    711 rdf:type schema:CreativeWork
    712 https://doi.org/10.1158/0008-5472.can-07-5756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034985371
    713 rdf:type schema:CreativeWork
    714 https://doi.org/10.1158/0008-5472.can-07-6567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018778194
    715 rdf:type schema:CreativeWork
    716 https://doi.org/10.1158/0008-5472.can-07-6721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005977242
    717 rdf:type schema:CreativeWork
    718 https://doi.org/10.1158/1078-0432.ccr-05-0149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019784284
    719 rdf:type schema:CreativeWork
    720 https://doi.org/10.1158/1078-0432.ccr-07-1186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021171574
    721 rdf:type schema:CreativeWork
    722 https://doi.org/10.1158/1078-0432.ccr-07-4007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013573135
    723 rdf:type schema:CreativeWork
    724 https://doi.org/10.1158/1078-0432.ccr-07-5074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019603004
    725 rdf:type schema:CreativeWork
    726 https://doi.org/10.1158/1535-7163.mct-07-0482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034459324
    727 rdf:type schema:CreativeWork
    728 https://doi.org/10.1158/1940-6207.capr-08-0022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038850538
    729 rdf:type schema:CreativeWork
    730 https://doi.org/10.1158/1940-6207.capr-08-0081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036462269
    731 rdf:type schema:CreativeWork
    732 https://doi.org/10.1172/jci13505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043705336
    733 rdf:type schema:CreativeWork
    734 https://doi.org/10.1172/jci30558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022767489
    735 rdf:type schema:CreativeWork
    736 https://doi.org/10.1200/jco.2009.19.6410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044475739
    737 rdf:type schema:CreativeWork
    738 https://doi.org/10.1200/jco.2009.22.1630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027818369
    739 rdf:type schema:CreativeWork
    740 https://doi.org/10.1210/jc.2007-1736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064290213
    741 rdf:type schema:CreativeWork
    742 https://doi.org/10.1242/jcs.016634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015127537
    743 rdf:type schema:CreativeWork
    744 https://doi.org/10.1242/jcs.02670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036903006
    745 rdf:type schema:CreativeWork
    746 https://doi.org/10.1242/jcs.032706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025478711
    747 rdf:type schema:CreativeWork
    748 https://doi.org/10.1371/journal.pbio.1000038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007831702
    749 rdf:type schema:CreativeWork
    750 https://doi.org/10.1371/journal.pmed.0050008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028686736
    751 rdf:type schema:CreativeWork
    752 https://doi.org/10.1371/journal.pone.0004264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044355838
    753 rdf:type schema:CreativeWork
    754 https://doi.org/10.1371/journal.pone.0005137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017573211
    755 rdf:type schema:CreativeWork
    756 https://doi.org/10.1523/jneurosci.1938-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024844073
    757 rdf:type schema:CreativeWork
    758 https://doi.org/10.1677/erc-08-0038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050553738
    759 rdf:type schema:CreativeWork
    760 https://doi.org/10.2337/db07-0843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023792893
    761 rdf:type schema:CreativeWork
    762 https://doi.org/10.2337/diabetes.49.12.2063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019256166
    763 rdf:type schema:CreativeWork
    764 https://doi.org/10.2337/diacare.29.02.06.dc05-1558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040586212
    765 rdf:type schema:CreativeWork
    766 https://doi.org/10.4161/auto.4240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290209
    767 rdf:type schema:CreativeWork
    768 https://doi.org/10.4161/cbt.6.10.4787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072294359
    769 rdf:type schema:CreativeWork
    770 https://doi.org/10.4161/cc.7.12.6016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072299490
    771 rdf:type schema:CreativeWork
    772 https://doi.org/10.4161/cc.7.24.7241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072299797
    773 rdf:type schema:CreativeWork
    774 https://www.grid.ac/institutes/grid.250671.7 schema:alternateName Salk Institute for Biological Studies
    775 schema:name Dulbecco Center for Cancer Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
    776 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...