Novel anticancer targets: revisiting ERBB2 and discovering ERBB3 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-07

AUTHORS

José Baselga, Sandra M Swain

ABSTRACT

Aberrant receptor expression or functioning of the epidermal growth factor receptor (Erbb) family plays a crucial part in the development and evolution of cancer. Inhibiting the signalling activity of individual receptors in this family has advanced the treatment of a range of human cancers. In this Review we re-evaluate the role of two important family members, ERBB2 (also known as HER2) and ERBB3 (also known as HER3), and explore the mechanisms of action and preclinical and clinical data for new therapies that target signalling through these pivotal receptors. These new therapies include tyrosine kinase inhibitors, antibody-chemotherapy conjugates, heat-shock protein inhibitors and antibodies that interfere with the formation of ERBB2-ERBB3 dimers. More... »

PAGES

463-475

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  • Journal

    TITLE

    Nature Reviews Cancer

    ISSUE

    7

    VOLUME

    9

    Related Patents

  • Immunocytokines In Combination With Anti-Erbb Antibodies For The Treatment Of Cancer
  • Binding Molecules Specific For Her3 And Uses Thereof
  • Anti-Her3 Antibodies Binding To The Beta-Hairpin Of Her3
  • Hetero-Dimeric Immunoglobulins
  • Phosphorus Containing Quinazoline Compounds And Methods Of Use
  • Use Of Erbb3 Inhibitors In The Treatment Of Triple Negative And Basal-Like Breast Cancers
  • Anti-Her3/Her4 Antibodies Binding To The Beta-Hairpin Of Her3 And The Beta-Hairpin Of Her4
  • Anti Her3 Antibody For Diagnosis, Prevention And Treatment Of Hyperproliferative Diseases
  • Use Of Erbb3 Inhibitors In The Treatment Of Triple Negative And Basal-Like Breast Cancers
  • Biomarker Profiles For Predicting Outcomes Of Cancer Therapy With Erbb3 Inhibitors And/Or Chemotherapies
  • Antigen Binding Protein Against Her3
  • Her3 Antibodies Binding To The Beta-Hairpin Of Her3
  • Antibodies Against Erbb3 And Uses Thereof
  • Inhibitors Of Phosphatidic Acid Phosphohydrolase (Pap), Including D-Propranolol And Analogs Thereof, Alone Or In Combination With Desipramine, For The Treatment Of Cancers That Depend On The Epidermal Growth Factor Receptor (Egfr), Oncogenic Variants Thereof And Other Members Of The Erbb/Her Family
  • Humanized Pan-Her Antibody Compositions
  • Use Of Erbb3 Inhibitors In The Treatment Of Triple Negative And Basal-Like Breast Cancers
  • Binding Molecules Specific For Her3 And Uses Thereof
  • Anti-Erbb3 Antibody
  • Materials And Methods For Treating Estrogen Receptor Α (Er) Positive Cancer
  • Acetyltanshinone Iia (Ata) As Anticancer Agent
  • Antibodies Against The Ectodomain Of Erbb3 And Uses Thereof
  • Methods For Treating Cancer By Administering Humanized Pan-Her Antibody Compositions
  • Pan-Her Antibody Composition
  • Alkyne Substituted Quinazoline Compound And Methods Of Use
  • Quinazoline-7-Ether Compounds And Methods Of Use
  • Anti-Erbb3 Antibody
  • Erbb3 Binding Antibody
  • Anti-Erbb3 Antibody
  • Use Of Erbb3 Inhibitors In The Treatment Of Triple Negative And Basal-Like Breast Cancers
  • Hetero-Dimeric Immunoglobulins
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc2656

    DOI

    http://dx.doi.org/10.1038/nrc2656

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035598015

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19536107


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