Cell cycle, CDKs and cancer: a changing paradigm View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-03

AUTHORS

Marcos Malumbres, Mariano Barbacid

ABSTRACT

Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as genomic and chromosomal instability. According to current models, mammalian CDKs are essential for driving each cell cycle phase, so therapeutic strategies that block CDK activity are unlikely to selectively target tumour cells. However, recent genetic evidence has revealed that, whereas CDK1 is required for the cell cycle, interphase CDKs are only essential for proliferation of specialized cells. Emerging evidence suggests that tumour cells may also require specific interphase CDKs for proliferation. Thus, selective CDK inhibition may provide therapeutic benefit against certain human neoplasias. More... »

PAGES

153-166

References to SciGraph publications

  • 2004-05. In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C in NATURE CELL BIOLOGY
  • 2008-02. The ubiquitin ligase APCCdh1 is required to maintain genome integrity in primary human cells in ONCOGENE
  • 2005-04. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis in NATURE
  • 2005-08. BRAFE600-associated senescence-like cell cycle arrest of human naevi in NATURE
  • 2007-08. Cdk1 is sufficient to drive the mammalian cell cycle in NATURE
  • 2001-01. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells in NATURE
  • 2008-08. Single-strand break repair and genetic disease in NATURE REVIEWS GENETICS
  • 2006-06. Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C in NATURE CELL BIOLOGY
  • 2006-04. The reversibility of mitotic exit in vertebrate cells in NATURE
  • 1992-07. Wild-type p53 activates transcription in vitro in NATURE
  • 1998-03. Mutations of mitotic checkpoint genes in human cancers in NATURE
  • 1993-12. p21 is a universal inhibitor of cyclin kinases in NATURE
  • 2001-06. Specific protection against breast cancers by cyclin D1 ablation in NATURE
  • 2005-02. Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells in NATURE CELL BIOLOGY
  • 1992-07. p53, guardian of the genome in NATURE
  • 1997-02. Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer in NATURE MEDICINE
  • 1997-02. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas in NATURE MEDICINE
  • 2004-10. Checking on DNA damage in S phase in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2006-11. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication in NATURE
  • 2003-11. Characterization of the abnormal pancreatic development, reduced growth and infertility in Cdk4 mutant mice in ONCOGENE
  • 2005-08. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis in NATURE
  • 2004-07. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice in NATURE GENETICS
  • 2008-09. E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8 in NATURE
  • 2006-09. The anaphase promoting complex/cyclosome: a machine designed to destroy in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2005-04. Cell cycle in mouse development in ONCOGENE
  • 2008-03. Genome instability: a mechanistic view of its causes and consequences in NATURE REVIEWS GENETICS
  • 2005-04. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions in NATURE
  • 2008-10-02. CDK targets Sae2 to control DNA-end resection and homologous recombination in NATURE
  • 2007-12. CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin? in NATURE REVIEWS CANCER
  • 2005-03. CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair in NATURE
  • 2007-03. Patterns of somatic mutation in human cancer genomes in NATURE
  • 1997-01. Delayed early embryonic lethality following disruption of the murine cyclin A2 gene in NATURE GENETICS
  • 2008-07. Genomic stability and tumour suppression by the APC/C cofactor Cdh1 in NATURE CELL BIOLOGY
  • 2008-09. Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells in ONCOGENE
  • 2004-12. Aurora-kinase inhibitors as anticancer agents in NATURE REVIEWS CANCER
  • 1993-12. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 in NATURE
  • 2008-11. Cyclin-dependent kinases and cell-cycle transitions: does one fit all? in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2006-09. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers in NATURE GENETICS
  • 2006-09. p16INK4a induces an age-dependent decline in islet regenerative potential in NATURE
  • 2008-10. Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2005-08. Cdc2–cyclin E complexes regulate the G1/S phase transition in NATURE CELL BIOLOGY
  • 2005-04. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy in NATURE
  • 2003-09. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice in NATURE GENETICS
  • 2008-08. ATR: an essential regulator of genome integrity in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1992-03. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours in NATURE
  • 2007-03. 14-3-3σ controls mitotic translation to facilitate cytokinesis in NATURE
  • 2006-11. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints in NATURE
  • 1975-08. Genetic control of cell size at cell division in yeast in NATURE
  • 2008-09. CDK8 is a colorectal cancer oncogene that regulates β-catenin activity in NATURE
  • 1987-05. Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2 in NATURE
  • 2004-11. Cell-cycle checkpoints and cancer in NATURE
  • 2004-11. G1 cell-cycle control and cancer in NATURE
  • 2005-10. On the road to cancer: aneuploidy and the mitotic checkpoint in NATURE REVIEWS CANCER
  • 2007-11. Finishing mitosis, one step at a time in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2007-02. Multiple levels of cyclin specificity in cell-cycle control in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2005-08. Oncogene-induced senescence as an initial barrier in lymphoma development in NATURE
  • 2006-05. Ubiquitin ligases: cell-cycle control and cancer in NATURE REVIEWS CANCER
  • 2004-11. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B in NATURE GENETICS
  • 2003-08. Genetic rescue of Cdk4 null mice restores pancreatic β-cell proliferation but not homeostatic cell number in ONCOGENE
  • 2005-08. Tumour biology: Senescence in premalignant tumours in NATURE
  • 2007-01. Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation in NATURE GENETICS
  • 2006-09. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a in NATURE
  • 2001-12. Milestones in cell division : To cycle or not to cycle: a critical decision in cancer in NATURE REVIEWS CANCER
  • 1999-05. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia in NATURE GENETICS
  • 2007-05. The spindle-assembly checkpoint in space and time in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2006-09. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing in NATURE
  • 2006-04. Targeting polo-like kinase 1 for cancer therapy in NATURE REVIEWS CANCER
  • 2008-07. Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells in NATURE
  • 2008-09. The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory in NATURE CELL BIOLOGY
  • 2007-12. Oncogenes and tumour suppressors take on centrosomes in NATURE REVIEWS CANCER
  • 2006-05. Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication in ONCOGENE
  • Journal

    TITLE

    Nature Reviews Cancer

    ISSUE

    3

    VOLUME

    9

    Clinical Trials linked to this publication

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc2602

    DOI

    http://dx.doi.org/10.1038/nrc2602

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008867916

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19238148


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