Targeting cancer with small molecule kinase inhibitors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-01

AUTHORS

Jianming Zhang, Priscilla L. Yang, Nathanael S. Gray

ABSTRACT

Key PointsSmall-molecule kinase inhibitors are being intensively pursued as new anticancer therapeutics. To date, approximately 80 inhibitors have been advanced to some stage of clinical evaluation.Understanding the structural basis of kinase inhibitor selectivity is crucial to the ultimate goal of developing selective inhibitors to target every member of the kinome. Most currently known kinase inhibitors target the ATP binding site with the kinase activation loop in the active (type 1) or inactive (type 2) conformation.New kinase inhibitors are primarily developed with a combination of methods, including high-throughput screening using biochemical or cellular assays, analogue synthesis, structure-guided design and fragment-based assembly strategies.The repertoire of kinases targeted by a given inhibitor can be determined by profiling its activity in binding and enzymatic assays against extensive panels of recombinant kinases, by profiling activity in cellular assays and by affinity approaches integrated with detection by mass spectrometry.Kinase inhibitor resistance resulting from selection for mutant alleles or upregulation of alternative signalling pathways is a recurrent theme in the clinic. Strategies for developing multiple inhibitors targeting different kinase sites and for discovering synergistic inhibitor combinations are urgently needed. More... »

PAGES

28-39

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  • Journal

    TITLE

    Nature Reviews Cancer

    ISSUE

    1

    VOLUME

    9

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc2559

    DOI

    http://dx.doi.org/10.1038/nrc2559

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001079875

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19104514


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