Cancer stem cells in solid tumours: accumulating evidence and unresolved questions View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-10

AUTHORS

Jane E Visvader, Geoffrey J Lindeman

ABSTRACT

Solid tumours are an enormous cancer burden and a major therapeutic challenge. The cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for the therapeutic refractoriness and dormant behaviour exhibited by many of these tumours. There is increasing evidence that diverse solid tumours are hierarchically organized and sustained by a distinct subpopulation of CSCs. Direct evidence for the CSC hypothesis has recently emerged from mouse models of epithelial tumorigenesis, although alternative models of heterogeneity also seem to apply. The clinical relevance of CSCs remains a fundamental issue but preliminary findings indicate that specific targeting may be possible. More... »

PAGES

755-768

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  • Journal

    TITLE

    Nature Reviews Cancer

    ISSUE

    10

    VOLUME

    8

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc2499

    DOI

    http://dx.doi.org/10.1038/nrc2499

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030818260

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18784658


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